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PI3K-PTEN imbalance is a potential new therapeutic target in COPD

Research Project

Project/Area Number 15K09185
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Respiratory organ internal medicine
Research InstitutionOsaka City University

Principal Investigator

Asai Kazuhisa  大阪市立大学, 大学院医学研究科, 講師 (10382053)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords慢性閉塞性肺疾患 / PI3K / PTEN / COPD / 気道炎症
Outline of Final Research Achievements

The PI3K (Phosphoinositide 3-kinase) -Akt signaling pathway is involved in angiogenesis,apoptosis,cell proliferation,production of inflammatory cytokines. And there is antagonistic mechanism by PTEN (Phosphatase and Tensin Homolog Deleted from Chromosome 10).
Airway epithelial cells were collected from 22 healthy non-smokers,31 healthy smokers, and 49 COPD patients.The expression of PI3K, PTEN in airway epithelial cells and its involvement in COPD pathogenesis were examined. In COPD patients, PTEN expression was significantly decreased, showing a significant inverse correlation with smoking history and significant correlation with pulmonary function testing.This suggested that PTEN was involved in COPD pathogenesis.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (24 results)

All 2018 2017 2016 2015

All Journal Article (16 results) (of which Peer Reviewed: 16 results,  Open Access: 7 results,  Acknowledgement Compliant: 2 results) Presentation (7 results) (of which Int'l Joint Research: 7 results) Book (1 results)

  • [Journal Article] Correlation between disease activity and serum ferritin in clinically amyopathic dermatomyositis with rapidly-progressive interstitial lung disease: a case report2018

    • Author(s)
      Yamada Kazuhiro、Asai Kazuhisa、Okamoto Atsuko、Watanabe Tetsuya、Kanazawa Hiroshi、Ohata Mai、Ohsawa Masahiko、Hirata Kazuto
    • Journal Title

      BMC Res Notes

      Volume: 11 Issue: 1 Pages: 1-2

    • DOI

      10.1186/s13104-018-3146-7

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] PIK3CA mutation as a distinctive genetic feature of non-small cell lung cancer with chronic obstructive pulmonary disease: A comprehensive mutational analysis from a multi-institutional cohort2017

    • Author(s)
      Sawa Kenji、Koh Yasuhiro、Kawaguchi Tomoya、Kambayashi Satoshi、Asai Kazuhisa、Mitsuoka Shigeki、Kimura Tatsuo、Yoshimura Naruo、Yoshimoto Naoki、Kubo Akihito、Saka Hideo、Matsumura Akihide、Wanibuchi Hideki、Yamamoto Nobuyuki、Nishiyama Noritoshi、Hirata Kazuto
    • Journal Title

      Lung Cancer

      Volume: 112 Pages: 96-101

    • DOI

      10.1016/j.lungcan.2017.07.039

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Decreased levels of irisin, a skeletal muscle cell-derived myokine, are related to emphysema associated with chronic obstructive pulmonary disease.2017

    • Author(s)
      Yukari Sugiyama、Kazuhisa Asai、Kazuhiro Yamada、Yuko Kureya、Naoki Ijiri、Tetsuya Watanabe、Hiroshi Kanazawa、Kazuto Hirata
    • Journal Title

      Int J Chron Obstruct Pulmon Dis.

      Volume: 12 Pages: 765-772

    • NAID

      120006330653

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Identification of a Novel Rhizopus-specific Antigen by Screening with a Signal Sequence Trap and Evaluation as a Possible Diagnostic Marker of Mucormycosis2017

    • Author(s)
      Sato K., Oinuma K., Niki M., Yamagoe S., Miyazaki Y., Asai K., Yamada K., Hirata K., Kaneko Y. and Kakeya H.
    • Journal Title

      Medical Mycology

      Volume: 55 Issue: 7 Pages: 713-719

    • DOI

      10.1093/mmy/myw146

    • URL

      https://ocu-omu.repo.nii.ac.jp/records/2020099

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Atrial natriuretic peptide protects against bleomycin-induced pulmonary fibrosis via vascular endothelial cells in mice : ANP for pulmonary fibrosis.2017

    • Author(s)
      Okamoto A, Nojiri T, Konishi K, Tokudome T, Miura K, Hosoda H, Hino J, Miyazato M, Kyomoto Y, Asai K, Hirata K, Kangawa K
    • Journal Title

      Respir Res

      Volume: 18 Issue: 1 Pages: 1-1

    • DOI

      10.1186/s12931-016-0492-7

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Decreased levels of irisin, a skeletal muscle cell-derived myokine, are related to emphysema associated with chronic obstructive pulmonary disease.2017

    • Author(s)
      Sugiyama Y, Asai K, Yamada K, Kureya Y, Ijiri N, Watanabe T, Kanazawa H, Hirata K
    • Journal Title

      International Journal of Chronic Obstructive Pulmonary Disease

      Volume: 12 Pages: 765-772

    • NAID

      120006330653

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Down-Regulation of Soluble α-Klotho is Associated with Reduction in Serum Irisin Levels in Chronic Obstructive Pulmonary Disease.2016

    • Author(s)
      Kureya Y, Kanazawa H, Ijiri N, Tochino Y, Watanabe T, Asai K, Hirata K.
    • Journal Title

      Lung.

      Volume: 194 Issue: 3 Pages: 345-351

    • DOI

      10.1007/s00408-016-9870-7

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] An Intrinsic Strain of Colistin-resistant <i>Acinetobacter</i> Isolated from a Japanese Patient2016

    • Author(s)
      Takizawa E., Yamada K., Oinuma K., Sato K., Niki M., Namikawa H., Fujimoto H., Asai K., Kaneko Y. and Kakeya H.
    • Journal Title

      Internal Medicine

      Volume: 55 Issue: 16 Pages: 2301-2306

    • DOI

      10.2169/internalmedicine.55.6807

    • NAID

      130005169382

    • ISSN
      0918-2918, 1349-7235
    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Efficacy and safety of indacaterol/glycopyrronium in Japanese patients with COPD: Pooled analysis of SHINE and ARISE.2016

    • Author(s)
      Asai K, Hirata K, Hashimoto S, Fukuchi Y, Kitawaki T, Ikeda K, Fogel R, Banerji D.
    • Journal Title

      Respir Investig.

      Volume: 54 Issue: 6 Pages: 428-435

    • DOI

      10.1016/j.resinv.2016.06.006

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Epidermal growth factor receptor tyrosine kinase inhibitors in previously treated advanced non-small-cell lung cancer with wild-type EGFR.2016

    • Author(s)
      Mitsuoka S, Kawaguchi T, Kubo A, Isa S, Asai K, Uji M, Watanabe T, Sawa K, Yoshimoto N, Oka T, Nakai T, Suzumura T, Tanaka H, Matsuura K, Kimura T, Yoshimura N, Kudoh S, Hirata K.
    • Journal Title

      Expert Opin Pharmacother.

      Volume: 17 Issue: 2 Pages: 193-203

    • DOI

      10.1517/14656566.2016.1109635

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Impaired nuclear factor erythroid 2-related factor 2 expression increases apoptosis of airway epithelial cells in patients with chronic obstructive pulmonary disease due to cigarette smoking.2016

    • Author(s)
      Yamada K, Asai K, Nagayasu F, Sato K, Ijiri N, Yoshii N, Imahashi Y, Watanabe T, Tochino Y, Kanazawa H, Hirata K.
    • Journal Title

      BMC Pulm Med.

      Volume: 16 Issue: 1 Pages: 27-27

    • DOI

      10.1186/s12890-016-0189-1

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Irisin, a newly discovered myokine, is a novel biomarker associated with physical activity in patients with chronic obstructive pulmonary disease.2015

    • Author(s)
      Ijiri N, Kanazawa H, Asai K, Watanabe T, Hirata K.
    • Journal Title

      Respirology

      Volume: 20 Issue: 4 Pages: 612-617

    • DOI

      10.1111/resp.12513

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Phase II study of a combination regimen of gefitinib and pemetrexed as first-line treatment in patients with advanced non-small cell lung cancer harboring a sensitive EGFR mutation.2015

    • Author(s)
      Yoshimura N, Kudoh S, Mitsuoka S, Yoshimoto N, Oka T, Nakai T, Suzumira T, Matusura K, Tochino Y, Asai K, Kimura T, Kawaguchi T, Hirata K.
    • Journal Title

      Lung Cancer

      Volume: 90 Issue: 1 Pages: 65-70

    • DOI

      10.1016/j.lungcan.2015.06.002

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Pentraxin-3 as a Biomarker for Febrile Neutropenia in Patients with Lung Cancer.2015

    • Author(s)
      Takeda N, Asai K, Ijiri N, Yamamoto N, Watanabe T, Kamoi H, Kanazawa H, Hirata K.
    • Journal Title

      Osaka City Med J.

      Volume: 61 Pages: 43-52

    • NAID

      120006493313

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Primary Pleural Synovial Sarcoma Treated with Pazopanib2015

    • Author(s)
      Sugitani A, Asai K, Kojima K, Eguchi Y, Kawaguchi T, Ohsawa M, Hirata K.
    • Journal Title

      Internal Medicine

      Volume: 54 Issue: 16 Pages: 2051-2055

    • DOI

      10.2169/internalmedicine.54.3570

    • NAID

      130005092891

    • ISSN
      0918-2918, 1349-7235
    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] The Macroscopic Appearance of Computed Tomography-guided Needle Biopsy Specimens Correlates with Tumor Metastasis in Non-small Cell Lung Cancer.2015

    • Author(s)
      Toshiyuki N, Kimura T, Suzumura T, Yoshimoto N, Oka T, Yamamoto N, Matsuura K, Mitsuoka S, Asai K, Tochino Y, Yoshimura N, Kawaguchi T, Kudoh S, Matsuoka T, Ohsawa M, Hirata K.
    • Journal Title

      Osaka City Med J.

      Volume: 61 Pages: 105-112

    • NAID

      120006493307

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Presentation] Relationship between peripheral blood irisin levels and muscle mass, sarcopenia, and pulmonary function measurements in COPD subjects.2016

    • Author(s)
      Shinya Yoshida, Kazuhisa Asai, Yukari Sugiyama, Yohkoh Kyomoto, Tamaki Kawamoto, Kanako Sato, Yuko Kureya, Atsuko Okamoto, Kazuhiro Yamada, Naoko Yoshii, Tetsuya Watanabe, Masato Uji, Hiroshi Kanazawa, Kazuto Hirata
    • Organizer
      21st Congress of the Asian Pacific Society of Respirology
    • Place of Presentation
      バンコク(タイ)
    • Year and Date
      2016-11-12
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Relationships between sarcopenia and pulmonary function, exercise capacity, and prognosis in patients with COPD2016

    • Author(s)
      yukari sugiyama, kazuhisa asai, shinya yoshida, yohkoh kyomoto, tamaki kawamoto, kanako sato, yuko kureya, atsuko okamoto, kazuhiro yamada, naoko yoshii, tetsuya watanabe, masato uji, kazuto hirata,
    • Organizer
      ERS International Congress 2016
    • Place of Presentation
      ロンドン(イギリス)
    • Year and Date
      2016-09-03
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Atrial Natriuretic Peptide Attenuates Bleomycin-Induced Pulmonary Fibrosis in Mice2016

    • Author(s)
      Atsuko Okamoto , Kazuhisa Konishi , Takashi Nojiri , Hiroshi Hosoda , Takeshi Tokudome , Kazuhisa Asai , Kazuto Hirata , Kenji Kangawa
    • Organizer
      American Thoracic Society 2016 International Conference
    • Place of Presentation
      サンフランシスコ(アメリカ合衆国)
    • Year and Date
      2016-05-13
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Expression Levels of Developmenal Genes Distinguish Non Specific Interstitial Pneumonia from Idiopathic Pulmonary Fibrosis and Highlight Potential Diagnostic Markers2016

    • Author(s)
      Kazuhisa Konishi , Yasuhiro Kondoh , Hiroyuki Taniguchi , Atsuko Okamoto , Kathleen O. Lindell , Kazuhisa Asai , Yingze Zhang , Kevin Gibson , Naftali Kaminski , Dong Soon Kim
    • Organizer
      American Thoracic Society 2016 International Conference
    • Place of Presentation
      サンフランシスコ(アメリカ合衆国)
    • Year and Date
      2016-05-13
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Decreased Nuclear Factor Erythroid 2-Related Factor 2 Expression Enhances Apoptosis of Airway Epithelial Cells in Patients with Chronic Obstructive Pulmonary Disease2016

    • Author(s)
      Kazuhiro Yamada , Kazuhisa Asai , Yuko Kubo , Yohkoh Kyomoto , Tamaki Kawamoto , Shinya Yoshida , Kanako Sato , Norio Yamamoto , Naoko Yoshii , Tetsuya Watanabe , Masato Uji , Kazuto Hirata
    • Organizer
      American Thoracic Society 2016 International Conference
    • Place of Presentation
      サンフランシスコ(アメリカ合衆国)
    • Year and Date
      2016-05-13
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] A case of rapidly progressed primary pleural synovial sarcoma.2015

    • Author(s)
      Kazuhisa Asai, Kanako Sato, Yuko Kubo, Atsuko Okamoto, Kazuhiro Yamada, Naoko Yoshii, Tetsuya Watanabe, Kazuhisa Konishi, Masato Uji, Kazuto Hirata
    • Organizer
      Chest Annual Meeting 2015
    • Place of Presentation
      モントリオール(カナダ)
    • Year and Date
      2015-10-25
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Global gene expression analyses highlight the role of cellular plasma remodeling as a molecular function of airway epithelium in response to interleukin-13 treatment.2015

    • Author(s)
      Yuko Kureya, Kazuhisa Konishi, Kazuhiro Yamada, Tetsuya Watanabe, Masato Uji, Kazuhisa Asai, Hiroshi Kanazawa, and Kazuto Hirata
    • Organizer
      European Respiratory Society International Congress 2015
    • Place of Presentation
      アムステルダム(オランダ)
    • Year and Date
      2015-09-26
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Book] Chronic Obstructive Pulmonary Disease: A Systemic Inflammatory Disease2016

    • Author(s)
      Hiroyuki Nakamura, Kazutetsu Aoshiba, et al.
    • Total Pages
      352
    • Publisher
      Springer
    • Related Report
      2016 Research-status Report

URL: 

Published: 2015-04-16   Modified: 2019-03-29  

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