Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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Outline of Final Research Achievements |
The PI3K (Phosphoinositide 3-kinase) -Akt signaling pathway is involved in angiogenesis,apoptosis,cell proliferation,production of inflammatory cytokines. And there is antagonistic mechanism by PTEN (Phosphatase and Tensin Homolog Deleted from Chromosome 10). Airway epithelial cells were collected from 22 healthy non-smokers,31 healthy smokers, and 49 COPD patients.The expression of PI3K, PTEN in airway epithelial cells and its involvement in COPD pathogenesis were examined. In COPD patients, PTEN expression was significantly decreased, showing a significant inverse correlation with smoking history and significant correlation with pulmonary function testing.This suggested that PTEN was involved in COPD pathogenesis.
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