Why is there an area priority during development of emphysema and fibrosis in the human lung? Approach to elucidate the mechanisms by mechanical property of the lung

• Project/Area Number: 15K09186
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Respiratory organ internal medicine
• Research Institution: Nara Medical University
• Principal Investigator: TOMODA KOICHI 奈良県立医科大学, 医学部, 病院教授 (90364059)
• Co-Investigator(Kenkyū-buntansha): 吉川 雅則 奈良県立医科大学, 医学部, 病院教授 (80271203) ; 木村 弘 日本医科大学, 大学院医学研究科, 教授 (20195374) ; 大崎 茂芳 奈良県立医科大学, 医学部, 研究員 (90273911)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: コラーゲン線維 / 配向性 / 気腫化 / 繊維化 / 不均等分布 / 力学特性 / 異方性 / 臨床呼吸器学 / 肺気腫 / 肺線維症

Outline of Final Research Achievements

We tried to elucidate the mechanisms there exists an area priority during development of emphysema and fibrosis in the human lung from a view point of mechanical property. On the lung without any lung diseases the collagen fiber was orientated mainly in up and down direction. The breaking stress was relatively higher in up and down direction than that in inner and outer direction. The mechanical anisotropy on the human lung was correlated with the anisotropy of the collagen fiber orientation. The distribution of the collagen fiber orientation on the lung with both emphysema and fibrosis is different from that without any lung diseases. Especially on the lung with emphysema there existed an area where the collagen fiber was highly orientated. These results may suggest that the mechanical stresses by respiration may contribute to the reconstruction in collagen fiber orientation during the development of emphysema.

Research Products

• [Journal Article] 骨粗鬆症リエゾンサービスにおける合併疾患 (2018)
  • Author(s): 友田 恒一
  • Journal Title: 腎と骨代謝 Volume: Vol.31 No.2 Pages: 139-144
• [Journal Article] Dietary changes involving Bifidobacterium longum and other nutrients delays CKD progression (2018)
  • Author(s): Iwashita Y., Ohya M., Yashiro M., Sonou T., Kawakami K., Tomoda.K., et al.
  • Journal Title: Am J Nephrol Volume: in press
  • Peer Reviewed
• [Journal Article] Microbiomeと呼吸器疾患慢性閉塞性疾患(COPD)との関わり (2017)
  • Author(s): 友田 恒一,木村 弘
  • Journal Title: 呼吸 Volume: １巻１号 Pages: 37-43
  • Open Access
• [Journal Article] Persimmon-derived tannin has bacteriostatic and anti-inflammatory activity in a murine model of Mycobacterium avium complex (MAC) disease. (2017)
  • Author(s): Matsumura Y., Kitabatake M., Ouji-Sageshima N., Yasui S., Mochida N., Tomoda K., et al.
  • Journal Title: PLoS One Volume: 12(8)
  • Peer Reviewed
• [Journal Article] Prevalence of chronic obstructive pulmonary disease in independent community-dwelling older adults:The Fujiwara-kyo study (2017)
  • Author(s): Yoshikawa M., Yamamoto Y., Tomoda K.,Fujita Y., Yamauchi M., et al.
  • Journal Title: Geriatr Gerontol Int., Volume: 17(12) Pages: 2421-2426
  • Peer Reviewed / Open Access
• [Journal Article] Silencing of carbohydrate sulforransferase 15 hinders murine pulmonary fibrosis development. (2017)
  • Author(s): Kai Y., Tomoda K., yoneyama H., kitabatake M., Nakamura A., et al
  • Journal Title: Molecular Therapy-Nucleic Acids Volume: 6 Pages: 163-172
  • Peer Reviewed / Open Access
• [Journal Article] Original Respiratory Monitoring System for Preventing Postoperative Life-Threatening Respiratory Events (2017)
  • Author(s): 惠川 淳二, 友田 恒一, 霧下 由美子, 小西 康司, 川口 昌彦, 古家 仁
  • Journal Title: THE JOURNAL OF JAPAN SOCIETY FOR CLINICAL ANESTHESIA Volume: 37 Issue: 7 Pages: 758-763
  • DOI: 10.2199/jjsca.37.758
  • NAID: 130006318270
  • ISSN: 0285-4945, 1349-9149
• [Journal Article] 慢性閉塞性肺疾患(COPD)とmicrobiome(解説) (2017)
  • Author(s): 友田 恒一(奈良県立医科大学附属病院 医療安全推進室)
  • Journal Title: 医学のあゆみ(0039-2359) Volume: 260巻2号 Pages: 169-170
• [Journal Article] Silencing of carbohydrate sulfotransferase 15 hinders murine pulmonary fibrosis development. (2017)
  • Author(s): Kai Y, Tomoda K, Yoneyama H, et al.
  • Journal Title: Molecular Therapy-Nucleic Acids. Volume: 6 Pages: 163-72
• [Journal Article] Hypertrophic Pachymeningitis as a Delayed Complication of Granulomatosis with Polyangiitis. (2016)
  • Author(s): Kumamoto M, Tomoda K, Furuya Y, et al.
  • Journal Title: Internal Medicine. Volume: 55(4) Pages: 413-7
  • NAID: 130005125794
• [Journal Article] Effect of Laughter Yoga on Pulmonary Rehabilitation in Patients with Chronic Obstructive Pulmonary Disease. (2016)
  • Author(s): Fukuoka A, Ueda M, Ariyama Y, et al.
  • Journal Title: J Nara Med Assoc. Volume: 67 Pages: 11-20
• [Journal Article] Acute Bilateral Renal and Splenic Infarctions Occurring during Chemotherapy for Lung Cancer. (2016)
  • Author(s): Koyama N, Tomoda K, Matsuda M, et al
  • Journal Title: Internal Medicine. Volume: 55(24) Pages: 3635-9
  • NAID: 130005250377
• [Journal Article] A case of acute bilateral renal and splenic infarctions occurring during chemotherapy for lung cancer. (2016)
  • Author(s): Koyama N, Tomoda K, Matsuda M, Fujita Y, Yamamoto Y, Hontsu S, Tasaki M, Yoshikawa M, Kimura H.
  • Journal Title: Intern Med. (In Press) Volume: 未定
• [Journal Article] Hypertrophic Pachymeningitis as a Delayed Complication of Granulomatosis with Polyangiitis (2016)
  • Author(s): Kumamoto M, Tomoda K, Furuya Y, Iwasa N, Ueno S, Yoshikawa M, Kimura H.
  • Journal Title: Internal Medicine Volume: 55 Issue: 4 Pages: 413-417
  • DOI: 10.2169/internalmedicine.55.5434
  • NAID: 130005125794
  • ISSN: 0918-2918, 1349-7235
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] RNA interference targeting carbohydrate sulfotransferase 3 diminishes macrophage accumulation, inhibits MMP-9 expression and promotes lung recovery in murine pulmonary emphysema. (2015)
  • Author(s): Kai Y, Tomoda K, Yoneyama H, Yoshikawa M, Kimura H.
  • Journal Title: Respir.Res. Volume: 16 Issue: 1 Pages: 146-146
  • DOI: 10.1186/s12931-015-0310-7
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Whey peptide-based enteral diet attenuated elastase-induced emphysema with increase in short chain fatty acids in mice. (2015)
  • Author(s): Tomoda K, Kubo K, Dairiki K, Yamaji T, Yamamoto Y, Nishii Y, Nakamura A, Yoshikawa M, Hamada K, Kimura H.
  • Journal Title: BMC Pulm Med Volume: 15 Issue: 1 Pages: 64-64
  • DOI: 10.1186/s12890-015-0059-2
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] 肺気腫形成過程における骨密度の変化に関する検討 (2018)
  • Author(s): 友田 恒一,久保 薫,吉川 雅則,兼平 裕也
  • Organizer: 日本呼吸器学会
• [Presentation] A study on the role of Adiponectin in the progressinon of chronic obstructive pulmonary disease (2018)
  • Author(s): T. Ibaraki, K. Tomoda, N. Fujioka, T. Jinta, Y. Yamamoto, M. Yam
  • Organizer: American Thoracic Society
  • Int'l Joint Research
• [Presentation] Anisotropy in mechanical property in the human lung was correlated with collagen fiber orientation (2017)
  • Author(s): K. Tomoda, S. Osaki and H. Kimura Department of Respiratory Medicine and Dermatology,
  • Organizer: American Thoracic Society
  • Place of Presentation: ワシントン アメリカ
  • Year and Date: 2017-05-20
  • Int'l Joint Research
• [Presentation] Two types of fiber in COPD (2017)
  • Author(s): K. Tomoda
  • Organizer: The 124 Annual Meeting of Korean Academy of Tuberculosis and Respiratory Diseases
  • Int'l Joint Research / Invited
• [Presentation] The Collagen Fiber Orientation In Human Lung Tissue With Emphysema (2017)
  • Author(s): K. Tomoda, S. Osaki, and H. KImura
  • Organizer: American Thoracic Society
  • Int'l Joint Research
• [Presentation] COPD研究の新展開 Microbiome(会議録) (2016)
  • Author(s): 友田 恒一(奈良県立医科大学 内科学第二講座), 木村 弘
  • Organizer: 日本呼吸器学会
  • Place of Presentation: 京都
  • Year and Date: 2016-04-08
• [Presentation] 疾患動物モデル コンドロイチン硫酸プロテオグリカンを標的にしたRNA干渉によるCOPD治療の試み(会議録) (2016)
  • Author(s): 甲斐 吉郎(奈良県立医科大学 第二内科), 友田 恒一, 米山 博之, 吉川 雅則, 木村 弘
  • Organizer: 日本呼吸器学会
  • Place of Presentation: 京都
  • Year and Date: 2016-04-08
• [Presentation] 呼吸器疾患におけるGUT-LUNG axis 症例からの検証 難治性NTM症例に対するシンバイオティックス投与の試み(会議録/症例報告) (2016)
  • Author(s): 茨木 敬博(奈良県立医科大学 内科学第二講座), 友田 恒一, 吉川 雅則, 土居 昭広, 赤塚 沙知子, 中村 武彦, 木村 弘
  • Organizer: 日本呼吸器学会
  • Place of Presentation: 京都
  • Year and Date: 2016-04-08
• [Presentation] 呼吸器疾患におけるGUT-LUNG axis 症例からの検証 潰瘍性大腸炎経過中に活動性肺病変を認めた1例(会議録/症例報告) (2016)
  • Author(s): 藤岡 伸啓(奈良県立医科大学 内科学第二講座), 友田 恒一, 濱田 薫, 小山 文一, 中島 祥介, 三浦 幸子, 吉川 公彦, 吉川 雅則, 木村 弘
  • Organizer: 日本呼吸器学会
  • Place of Presentation: 京都
  • Year and Date: 2016-04-08
• [Presentation] 1.COPD患者における骨格筋指数と骨塩量および運動耐容能との関連 (2015)
  • Author(s): 山本佳史、吉川雅則、寺本佳奈子、藤田幸男、山内基雄、児山紀子、友田恒一、木村弘
  • Organizer: 第25回日本呼吸ケアリハビリテーション学会
  • Place of Presentation: 東京ベイ舞浜ホテル クラブリゾート（千葉県浦安市）
  • Year and Date: 2015-10-15
• [Presentation] Synbiotics attenuate not only pulmonary emphysema but also osteoporosis induced by cigarette smoke in rats. (2015)
  • Author(s): Tomoda K, Kubo K, Yamamoto Y, Koyama N, Yoshikawa M and Kimura H.
  • Organizer: American Thoracic Society international conference
  • Place of Presentation: Denver(U.S.A)
  • Year and Date: 2015-05-15
  • Int'l Joint Research
• [Presentation] New targets for systemic effects in COPD. (2015)
  • Author(s): Tomoda K, Kubo K, Yamamoto Y, Yoshikawa M and Kimura H.
  • Organizer: 第55回 日本呼吸器学会学術講演会
  • Place of Presentation: 東京国際フォーラム（東京都千代田区）
  • Year and Date: 2015-04-17
• [Presentation] Acceleration in emphysema in rats discontinuously fed with fiber-free diet were related to alteration in the gut environment. (2015)
  • Author(s): Tomoda K, Kubo K, Yamamoto Y, Yoshikawa M and Kimura H.
  • Organizer: 第55回日本呼吸器学会学術講演会
  • Place of Presentation: 東京国際フォーラム（東京都千代田区）
  • Year and Date: 2015-04-17
• [Presentation] COPD患者におけるサルコペニアと骨塩量および運動能との関連 (2015)
  • Author(s): 寺本佳奈子、吉川雅則、山本佳史、友田恒一、藤田幸男、山内基雄、児山紀子、熊本牧子、長 敬翁、鵜山広樹、木村 弘
  • Organizer: 第55回日本呼吸器学会学術講演会
  • Place of Presentation: 東京国際フォーラム（東京都千代田区）
  • Year and Date: 2015-04-17
• [Presentation] わが国のCOPD患者を対象としたBODE indexの妥当性 (中間報告) (2015)
  • Author(s): 山本佳史、吉川雅則、藤田幸男、山内基雄、熊本牧子、児山紀子、友田恒一、木村 弘
  • Organizer: 第55回日本呼吸器学会学術講演会
  • Place of Presentation: 東京国際フォーラム（東京都千代田区）
  • Year and Date: 2015-04-17
• [Presentation] 藤原京スタディーにおける高齢一般住民とCOPD患者の併存症の比較 (2015)
  • Author(s): 長 敬翁、吉川雅則、友田恒一、山本佳史、熊本牧子、児山紀子、山内基雄、岡本 希、車谷典男、木村 弘
  • Organizer: 第55回日本呼吸器学会学術講演会
  • Place of Presentation: 東京国際フォーラム（東京都千代田区）
  • Year and Date: 2015-04-17
• [Presentation] COPD患者における身体活動性の検討―藤原京スタディーにおける高齢一般住民との比較 (2015)
  • Author(s): 藤田幸男、吉川雅則、友田恒一、山本佳史、熊本牧子、児山紀子、山内基雄、岡本 希、車谷典男、木村 弘
  • Organizer: 第55回日本呼吸器学会学術講演会
  • Place of Presentation: 東京国際フォーラム（東京都千代田区）
  • Year and Date: 2015-04-17