| Project/Area Number |
15K09197
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Nippon Medical School |
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Principal Investigator |
Ishii Takeo 日本医科大学, 大学院医学研究科, 研究生 (90445750)
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| Co-Investigator(Kenkyū-buntansha) |
新井 富生 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究員 (20232019)
辻 隆夫 東京医科大学, 医学部, 兼任講師 (30459664)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | COPD / 増悪（exacerbation） / gap junction / 遺伝子多型 （SNP) / 病態関連遺伝子 / バイオマーカー / 増悪 / 遺伝子多型（SNP) / 遺伝子多型（SNP） / 遺伝子多型 |
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| Outline of Final Research Achievements |
Though COPD exacerbation is triggered by infection, structural change of the lung in the progression of emphysema formation could also affect susceptibility of exacerbation. Thus, we investigated the association between genetic variations of Cx43, a gap-junction protein, and sussceptibility of COPD exacerbation, and also assess the mechanism of COPD exacerbation through gap-junction protein including Cx43. A SNP in Cx 43, namely rs9320841, was significantly related to the frequency of COPD exacerbations in a Japanese population. This SNP was also related to the expression of cytokines including IL1beta in the mononulcear cells of COPD patients when stimulated with some bacteria which have LPS. Thus, we suspect taht TLR and CX43 has relationshiop on the cell surface of these cells via intracellular or intercellular manner to induce inflammation due to COPD exacerbations. We now further analyze the mechanism through in-vivo exacerbation murine model and pathological point of view.
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