Non-invasive pathological imaging of interstitial pneumonia using probe type confocal laser endomicroscopy
Project/Area Number |
15K09198
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Respiratory organ internal medicine
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Research Institution | Fujita Health University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
磯谷 澄都 藤田保健衛生大学, 医学部, 講師 (10351032)
|
Project Period (FY) |
2015-04-01 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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Keywords | 間質性肺炎 / 共焦点レーザー顕微鏡 / 内視鏡診断 / プローブ型共焦点レーザー顕微鏡 / びまん性肺疾患 / 病理診断 / 呼吸器内視鏡診断 / 共焦点蛍光顕微内視鏡 / 肺胞蛋白症 |
Outline of Final Research Achievements |
We investigated probe type confocal laser microendoscopy images of diffuse lung diseases including UIP and NSIP. In UIP, auto-fluorescence of peripheral lung was significantly reduced than NSIP. Fragmentation of alveolar fluorescence was more observed in UIP than NSIP. In contrast, regular compression of alveolar wall was more observed in NSIP. pCLE imaging study of surgical biopsy specimens revealed that irregular alveolar wall changes, alveolar remodeling, and irregular alveolar compression are specific findings for UIP. In cases with pulmonary alveolar proteinosis, we could confirm disease specific findings (giant alveolar cells with strong auto- fluorescence, amorphous fluid with weak fluorescence, and thin alveolar walls) even in early stage of the disease. Theses findings suggest pCLE imaging could be a promising and non-invasive diagnostic tool for diffuse lung diseases.
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Report
(4 results)
Research Products
(16 results)
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[Journal Article] Feasibility of tissue re-biopsy in non-small cell lung cancers resistant to previous epidermal growth factor receptor tyrosine kinase inhibitor therapies.2017
Author(s)
Uozu S, Imaizumi K, Yamaguchi T, Goto Y, Kawada K, Minezawa T, Okamura T, Akao K, Hayashi M, Isogai S, Okazawa M, Hashimoto N, Hasegawa Y.
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Journal Title
BMC Pulm Med
Volume: 17
Issue: 1
Pages: 175-184
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Exogenous induction of unphosphorylated PTEN reduces TGFβ-induced extracellular matrix expressions in lung fibroblasts.2017
Author(s)
Kimura M, Hashimoto N, Kusunose M, Aoyama D, Sakamoto K, Miyazaki S, Ando A, Omote N, Imaizumi K, Kawabe T, Hasegawa Y.
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Journal Title
Wound Repair Regen.
Volume: 25
Issue: 1
Pages: 86-97
DOI
Related Report
Peer Reviewed
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[Journal Article] Increased airway hyperresponsiveness to adenosine in patients with aspirin intolerant asthma2017
Author(s)
Isogai S, Niwa Y, Yatsuya H, Hayashi M, Yamamoto N, Okamura T, Minezawa T, Goto Y, Yamaguchi T, Takeyama T, Sakakibara Y, Morikawa S, Horiguchi T, Gotoh Y, Mieno Y, Uozu S, Nakanishi T, Okazawa M, Sakakibara H, Imaizumi K.
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Journal Title
Allergology International
Volume: 66
Issue: 2
Pages: 360-362
DOI
NAID
ISSN
1323-8930, 1440-1592
Related Report
Peer Reviewed / Open Access
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[Journal Article] A simple method of bronchial occlusion with silicone spigots (Endobronchial Watanabe Spigot; EWS) using a curette.2016
Author(s)
Morikawa S, Okamura T, Minezawa T, Goto Y, Hayashi M, Yamaguchi T, Isogai S, Mieno Y, Yamamoto N, Uozu S, Nakanishi T, Okazawa M, Imaizumi K.
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Journal Title
Ther Adv Respir Dis.
Volume: 10
Pages: 518-524
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Comparison between 5-day aprepitant and single-dose fosaprepitant meglumine for preventing nausea and vomiting induced by cisplatin-based chemotherapy.2016
Author(s)
Ando Y, Hayashi T, Ito K, Suzuki E, Mine N, Miyamoto A, Oya M, Matsuda H, Isaji A, Nakanishi T, Imaizumi K, Shibata T, Okada T, Sakurai K, Naito K, Uyama I, Kawada K, Takahashi H, Yamada S.
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Journal Title
Supportive Care in Cancer.
Volume: 24
Issue: 2
Pages: 871878-871878
DOI
Related Report
Peer Reviewed
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[Journal Article] Direct regulation of transforming growth factor β-induced epithelial-mesenchymal transition by the protein phosphatase activity of unphosphorylated PTEN in lung cancer cells.2015
Author(s)
Kusunose M, Hashimoto N, Kimura M, Ogata R, Aoyama D, Sakamoto K, Miyazaki S, Ando A, Omote N, Imaizumi K, Kawabe T, Hasegawa Y.
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Journal Title
Cancer Science
Volume: 106
Issue: 12
Pages: 1693-704
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] Probe-based Confocal Laser Endomicroscopy (pCLE) for Early Stage Pulmonary Alveolar Proteinosis2016
Author(s)
Imaizumi K, Okamura T, Minezawa T, Morikawa S, Niwa Y, Yamaguchi T, Uozu S, Goto Y, Hayashi M, Isogai S, Nakanishi T
Organizer
19th WCBIP/WCBE World Congress,
Place of Presentation
Florence, Italy
Year and Date
2016-05-08
Related Report
Int'l Joint Research
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[Presentation] プローブ型共焦点レーザー内視鏡による肺胞蛋白症診断2016
Author(s)
今泉和良、岡村拓哉,峯澤智之,森川紗也子,渡邊俊和,相馬智英,丹羽義和,赤尾 謙,武山知子,堀口智也,後藤祐介,榊原洋介,山口哲平,魚津桜子,三重野ゆうき,後藤康洋,林 正道,磯谷澄都,中西 亨
Organizer
第56回日本呼吸器学会学術講演会
Place of Presentation
国立京都国際会館
Year and Date
2016-04-08
Related Report
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