A study on the role and therapeutic application of B cell activation factor in autoimmune alveolar proteinosis
| Project/Area Number |
15K09203
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Clinical Research Center, National Hospital Organization, Kinki-Chuo Chest Medical Center |
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Principal Investigator |
HIROSE MASAKI 独立行政法人国立病院機構(近畿中央胸部疾患センター臨床研究センター), 臨床研究センター, 流動研究員 (90470195)
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| Co-Investigator(Kenkyū-buntansha) |
井上 義一 独立行政法人国立病院機構(近畿中央胸部疾患センター臨床研究センター), 臨床研究センター, 臨床研究センター長 (90240895)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 自己免疫性肺胞蛋白症 / 自己免疫性疾患 / B細胞 |
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| Outline of Final Research Achievements |
We confirmed that B cell activation factors, BAFF and APRIL, were overproduced in the patients with autoimmune pulmonary alveolar proteinosis (APAP) in serum and bronchial alveolar lavage fluid compared to healthy subjects and other lung diseases. And we also confirmed that alveolar macrophages express BAFF and APRIL in the PAP lesion Immunohistochemically. As a result of overproduction of B cell activating factor, an increase in B cells was considered but a remarkable increase could not be confirmed.
Our results suggest that the need for multidisciplinary treatment such as total lung lavage, inhalation of GM-CSF, suppression of B cell activating factor is indicated for APAP treatment.
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Report
(4 results)
Research Products
(26 results)
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[Journal Article] Classification of idiopathic interstitial pneumonias using anti-myxovirus resistance-protein 1 autoantibody2017
Author(s)
Hamano Y, Kida H, Ihara S, Murakami A, Yanagawa M, Ueda K, Honda O, Tripathi LP, Arai T, Hirose M, Hamasaki T, Yano Y, Kimura T, Kato Y, Takamatsu H, Otsuka T, Minami T, Hirata H, Inoue K, Nagatomo I, Takeda Y, Mori M, Nishikawa H, Mizuguchi K, Kijima T, Kitaichi T, Tomiyama N, Inoue Y, Kumanogoh A
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Journal Title
Scientific Reports
Volume: 23
Issue: 1
Pages: 43201-43201
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Risk factors for stomatitis in patients with lymphangioleiomyomatosis during treatment with sirolimus: A multicenter investigator-initiated prospective study.2017
Author(s)
Kitamura N, Seyama K, Inoue Y, Nagai K, Suzuki M, Moriyama H, Takada T, Tazawa R, Hirai T, Mishima M, Hayashida M, Hirose M, Arai T, Sugimoto C, Hattori N, Watanabe K, Tamada T, Akazawa K, Tanaka T, Nakata K.
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Journal Title
Pharmacoepidemiol Drug Saf.
Volume: 26
Issue: 10
Pages: 1182-1189
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Efficacy and Safety of Long-Term Sirolimus Therapy for Asian Patients with Lymphangioleiomyomatosis2016
Author(s)
Takada T, Mikami A, Kitamura N, Seyama K, Inoue Y, Nagai K, Suzuki M, Moriyama H, Akasaka K, Tazawa R, Hirai T, Mishima M, Hayashida M, Hirose M, Sugimoto C, Arai T, Hattori N, Watanabe K, Tamada T, Yoshizawa H, Akazawa K, Tanaka T, Yagi K, Young LR, McCormack FX, Nakata K
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Journal Title
AnnalsATS
Volume: 13
Issue: 11
Pages: 1912-1922
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] A mathematical model to predict protein wash out kinetics during whole-lung lavage in autoimmune pulmonary alveolar proteinosis2015
Author(s)
Keiichi Akasaka, Takahiro Tanaka, Takashi Maruyama, Nobutaka Kitamura, Atsushi Hashimoto, Yuko Ito, Hiroyoshi Watanabe, Tomoshige Wakayama, Takero Arai, Masachika Hayashi, Hiroshi Moriyama, Kanji Uchida, Shinya Ohkouchi, Ryushi Tazawa, Toshinori Takada, Etsuro Yamaguchi, Toshio Ichiwata, Masaki Hirose et al.
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Journal Title
Am J Physiol Lung Cell Mol Physiol
Volume: 14
Related Report
Peer Reviewed
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[Journal Article] Outcome of corticosteroid administration in autoimmune pulmonary alveolar proteinosis: a retrospective cohort study2015
Author(s)
Keiichi Akasaka, Takahiro Tanaka, Nobutaka Kitamura, Shinya Ohkouchi, Ryushi Tazawa, Toshinori Takada, Toshio Ichiwata, Etsuro Yamaguchi, Masaki Hirose, Toru Arai, Kentaro Nakano, Takahito Nei, Haruyuki Ishii, Tomohiro Handa, Yoshikazu Inoue and Koh Nakata
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Journal Title
BMC Pulmonary Medicine
Volume: 15
Issue: 1
Pages: 88-88
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Book] 呼吸2015
Author(s)
広瀬雅樹
Total Pages
14
Publisher
一般財団法人 呼吸研究
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