| Project/Area Number |
15K09205
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
Kanehira Masahiko 東北大学, 大学病院, 講師 (90374941)
Kikuchi Toshiaki 新潟大学, 大学病院, 教授 (10280926)
Irokawa Toshiya 東北大学, 事業支援機構, 准教授 (70375179)
Ogawa Hiromasa 東北大学, 事業支援機構, 准教授 (90361162)
Kurosawa Hajime 東北大学, 事業支援機構, 教授 (60333788)
Yamada Mitsuhiro 東北大学, 大学病院, 助教 (00396483)
Inoue Akira 東北大学, 大学病院, 教授 (70361087)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 肺線維症 / 間葉系幹細胞 / エピジェネティクス / 酸化ストレス / ERストレス / 障害ストレス応答 / 成長因子 / 老化 / STC1 / SASP / マクロファージ / ミトコンドリア / エピゲノム / メタボローム |
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| Outline of Final Research Achievements |
We showed that stannniocalcin-1 (STC1) released from mesenchymal stem cells control the mitochondrial respiration and wound healing signals in alveolar macrophage and lung epithelial cells under oxidative and endoplasmic reticulum stresses. STC1 intra-tracheal injection ameliorate bleomycin induced pulmonary fibrosis in animal model. At this time, we report the metabolome analyses to elucidate the molecular mechanism of STC1 which ameliorate the fibrosis. The results showed that STC1 control the cysteine and methionine metabolism strongly. This pathway regulates the methylation and de-methyration of DNA and histone and the synthesis of DNA, reactive sulfur species (RSS) with redox activities, and manage the stress response of the organs. These things suggest new insights of pathology of pulmonary fibrosis to us.
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