The analyses of cell type-specific extracellular vesicles derived from lung quiescent or cytokine-activated lung endothelial cells
Project/Area Number |
15K09206
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Respiratory organ internal medicine
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Research Institution | Tohoku University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
吉岡 祐亮 (吉岡祐亮) 国立研究開発法人国立がん研究センター, 研究所, 研究員 (60721503)
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Project Period (FY) |
2015-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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Keywords | バイオマーカー / COPD / IPF / エクソソーム / 細胞外小胞 / ARDS / マイクロパーティクル |
Outline of Final Research Achievements |
Serum EV miR-21-5p was elevated in both the acute inflammatory phase (day 7) and the chronic fibrotic phase (day 28) in the mouse model. In the clinical setting, serum EV miR-21-5p was significantly higher in IPF patients than in healthy control subjects. The baseline serum EV miR-21-5p was correlated with the rate of decline in vital capacity over 6 months. Furthermore, serum EV miR-21-5p was independently associated with mortality during the following 30 months, even after adjustment for other variables. In the survival analysis, IPF patients whose baseline serum EV miR-21-5p was high had a significantly poorer prognosis over 30 months. Our results suggest that serum EV miR-21-5p has potential as a prognostic biomarker for IPF.
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Report
(4 results)
Research Products
(22 results)
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[Journal Article] Invasive pulmonary mucormycosis: rare presentation with pulmonary eosinophilia.2017
Author(s)
Hirano T, Yamada M, Sato K, Murakami K, Tamai T, Mitsuhashi Y, Tamada T, Sugiura H, Sato N, Saito R, Tominaga J, Watanabe A, Ichinose M.
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Journal Title
BMC Pulm Med
Volume: 17
Issue: 1
Pages: 76-76
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Serum extracellular vesicular miR-21-5p is a predictor of the prognosis in idiopathic pulmonary fibrosis.2016
Author(s)
Makiguchi T, Yamada M, Yoshioka Y, Sugiura H, Koarai A, Chiba S, Fujino N, Tojo Y, Ota C, Kubo H, Kobayashi S, Yanai M, Shimura S, Ochiya T, Ichinose M.
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Journal Title
Respir Res
Volume: 17
Issue: 1
Pages: 110-110
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] The Detection of Cell Type-Specific Extracellular Vesicles Derived from Lung Epithelial Cells, Stable or Cytokine-Activated Endothelial Cells by Exoscreen.2015
Author(s)
Makiguchi T, Yamada M, Yoshioka Y, Sugiura H, Koarai A, Kubo H, Ochiya T, Kikuchi T, Ichinose M.
Organizer
American Thoracic Society International Conference
Place of Presentation
Denver, USA
Year and Date
2015-05-16
Related Report
Int'l Joint Research
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