| Project/Area Number |
15K09210
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Chiba University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
巽 浩一郎 千葉大学, 大学院医学研究院, 教授 (10207061)
江本 憲昭 神戸薬科大学, 薬学部, 教授 (30294218)
岩田 剛和 千葉県がんセンター(研究所), 呼吸器外科, 部長 (30586681)
田邉 信宏 千葉大学, 大学院医学研究院, 特任教授 (40292700)
鈴木 秀海 千葉大学, 大学院医学研究院, 講師 (60422226)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 肺動脈性肺高血圧症 / 肺移植 / 肺高血圧症 / ラット肺高血圧症モデル / 肺動脈リモデリング |
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| Outline of Final Research Achievements |
Refractory pulmonary arterial lesions against vasodilator drugs were confirmed in PAH rat model ( i.e., Su/Hx model). After a successful single lung transplant in normal rats, we tried a single lung transplant in Su/Hx model. However, almost transplants failed due to high pulmonary arterial pressure and right heart overload. In a very few successful cases, pulmonary lesions ameliorated. Subsequently, there was no successful lung transplant n Su/Hx model. Now, together with it, a single lung transplant between male and female rats was tried to elucidate pathophysiology of vascular lesions. Data about bone marrow derived cells in medial and intimal lesions are accumulated by using FISH analysis.
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