| Project/Area Number |
15K09212
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | University of Toyama |
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Principal Investigator |
Matsui Shoko 富山大学, 保健管理センター, 教授 (40334726)
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| Co-Investigator(Kenkyū-buntansha) |
伊藤 清亮 金沢大学, 附属病院, 医員 (10467110)
川野 充弘 金沢大学, 附属病院, 講師 (20361983)
林 龍二 富山大学, 附属病院, 教授 (60345585)
山田 和徳 金沢大学, 医薬保健学総合研究科, 特任准教授 (90397224)
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| Project Period (FY) |
2015-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | ＩｇＧ４関連肺疾患 / 自然免疫 / モデルマウス / IgG4関連疾患 / IgG4関連肺疾患 / 免疫学 |
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| Outline of Final Research Achievements |
IgG4-related disease (IgG4-RD) is a recently recognized systemic disease, characterized by tumefactive lesions with abundant IgG4-positive plasma cell infiltrates and elevated serum IgG4 concentrations. Although systemic corticosteroid therapy is effective, there is often recurrence of the lesion in IgG4-RD. We aimed to establish model mice of IgG4-RD and evaluated that the phenotypes of LatY136F knock-in mice form a pathological condition similar to IgG4-related lung disease. We also studied the involvement of innate immunity and its control in the lung lesions.
As a result, we found that innate immunity may be involved in the pathogenesis of IgG4-related lung disease and got clues for treatment other than glucocorticoids.
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| Academic Significance and Societal Importance of the Research Achievements |
IgG4 関連肺疾患発症および進展に関与する因子が同定されれば、病態の解明や診断や新規治療のターゲットとなり得ると考え、外界から刺激をうける呼吸器の自然免疫に着目した。その結果、モデルマウスを用いて自然免疫の関与を確認したことから、新たな治療法の手がかりを得ることができ、今後の研究の発展が望めると考えられた。
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