Immunotherapy for lung cancer with pulmonary fibrosis

• Project/Area Number: 15K09215
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Respiratory organ internal medicine
• Research Institution: Hamamatsu University School of Medicine
• Principal Investigator: Nakamura Yutaro 浜松医科大学, 医学部附属病院, 講師 (60436962)
• Co-Investigator(Kenkyū-buntansha): 須田 隆文 浜松医科大学, 医学部, 教授 (30291397)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 免疫療法 / 樹状細胞 / 肺癌 / 細胞性免疫 / がん免疫 / 肺線維症

Outline of Final Research Achievements

Lung cancer is the most deadly cancer in Japan. Type-1 immune response play a critical role in anti-tumor response via dendritic cells (DCs). We previously developed type-1 polarized DCs (DC1s), which induced strong anti-tumor effect in various animal tumor models. Here we showed that human DC1s significantly produced chemokines associated with type-1 immune resposnse. Furthermore human DC1s activated NK cells, and suppressed the proliferation of regulatory T cells. DC1s is a promising candidate for combination cancer therapy with currently available drugs.

Research Products

• [Journal Article] Type-1 polarised dendritic cells are a potent immunogen against Mycobacterium tuberculosis (2017)
  • Author(s): Satake Y.、Nakamura Y.、Kono M.、Hozumi H.、Nagata T.、Tsujimura K.、Enomoto N.、Fujisawa T.、Inui N.、Fujiyama T.、Tokura Y.、Matsui T.、Yokomura K.、Shirai M.、Hayakawa H.、Suda T.
  • Journal Title: The International Journal of Tuberculosis and Lung Disease Volume: 21 Issue: 5 Pages: 523-530
  • DOI: 10.5588/ijtld.16.0371
  • Peer Reviewed
• [Journal Article] Clinical diagnosis of idiopathic pleuroparenchymal fibroelastosis: A retrospective multicenter study. (2017)
  • Author(s): Enomoto Y, Nakamura Y, Satake Y, Sumikawa H, Johkoh T, Colby TV, Yasui H, Hozumi H, Karayama M, Suzuki Y, Furuhashi K, Fujisawa T, Enomoto N, Inui N, Iwashita T, Kuroishi S, Yokomura K, Koshimizu N, Toyoshima M, Imokawa S, Yamada T, Shirai T, Hayakawa H, Suda T.
  • Journal Title: Respir Med. Volume: 133 Pages: 1-5
  • DOI: 10.1016/j.rmed.2017.11.003
  • Peer Reviewed
• [Journal Article] Clinical significance of soluble CD163 in polymyositis-related or dermatomyositis-related interstitial lung disease (2017)
  • Author(s): Enomoto Y, Suzuki Y, Hozumi H, Mori K, Kono M, Karayama M, Furuhashi K, Fujisawa T, Enomoto N, Nakamura Y, Inui N, Suzuki D, Ogawa N, Nakashima R, Mimori T, Iwashita T, Suda T
  • Journal Title: Arthritis Res Ther Volume: 19 Issue: 1 Pages: 9-9
  • DOI: 10.1186/s13075-016-1214-8
  • NAID: 120005973333
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Utility of Macrophage-activated Marker CD163 for Diagnosis and Prognosis in Pulmonary Tuberculosis. (2017)
  • Author(s): Suzuki Y, Shirai M, Asada K, Miwa S, Karayama M, Nakamura Y, Inui N, Shirai T, Hayakawa H, Baba S, Suda T
  • Journal Title: Ann Am Thorac Soc Volume: 14 Issue: 1 Pages: 57-64
  • DOI: 10.1513/annalsats.201607-528oc
  • Peer Reviewed
• [Journal Article] 肺線維症合併肺癌-免疫療法の可能性も含めて (2017)
  • Author(s): 中村祐太郎, 須田隆文
  • Journal Title: 別冊BIO Clinica 慢性炎症と疾患 Volume: 6 Pages: 114-20
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Nonspecific interstitial pneumonia preceding diagnosis of collagen vascular disease. (2016)
  • Author(s): Kono M, Nakamura Y, Yoshimura K, Enomoto Y, Oyama Y, Hozumi H, Enomoto N,Fujisawa T, Inui N, Hamada E, Colby TV, Maekawa M, Suda T
  • Journal Title: Respir Med. Volume: 117 Pages: 40-47
  • DOI: 10.1016/j.rmed.2016.05.030
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Increased levels of serum Wisteria floribunda agglutinin-positive Mac-2 binding protein in idiopathic pulmonary fibrosis. (2016)
  • Author(s): Kono M, Nakamura Y, Oyama Y, Mori K, Hozumi H, Karayama M, Hashimoto D, Enomoto N, Fujisawa T, Inui N, Yamada M, Hamada E, Colby TV, Maekawa M, Suda T
  • Journal Title: Respir Med. Volume: 115 Pages: 46-52
  • DOI: 10.1016/j.rmed.2016.04.013
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Evaluation of palonosetron and dexamethasone with or without aprepitant to prevent carboplatin-induced nausea and vomiting in patients with advanced non-small-cell lung cancer. (2015)
  • Author(s): Kusagaya H, Inui N, Karayama M, Fujisawa T, Enomoto N, Kuroishi S, Nakamura Y, Matsuda H, Yokomura K, Koshimizu N, Toyoshima M, Imokawa S, Yamada T, Shirai T, Hayakawa H, Suda T.
  • Journal Title: Lung Cancer Volume: 90 Issue: 3 Pages: 410-6
  • DOI: 10.1016/j.lungcan.2015.11.009
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Nontypeable Haemophilus influenzae exploits the interaction between protein-E and vitronectin for the adherence and invasion to bronchial epithelial cells (2015)
  • Author(s): Ikeda M, Enomoto N, Hashimoto D, Fujisawa T, Inui N, Nakamura Y, Suda T
  • Journal Title: BMC Microbiol Volume: 15 Issue: 1 Pages: 263-263
  • DOI: 10.1186/s12866-015-0600-8
  • Peer Reviewed / Open Access
• [Journal Article] Synergistic Proinflammatory Responses by IL-17A and Toll-Like Receptor 3 in Human Airway Epithelial Cells (2015)
  • Author(s): Mori K, Fujisawa T, Kusagaya H, Yamanaka K, Hashimoto D, Enomoto N, Inui N, Nakamura Y, Maekawa M, Suda T
  • Journal Title: PLoS One Volume: 10 Issue: 9 Pages: e0139491-e0139491
  • DOI: 10.1371/journal.pone.0139491
  • Peer Reviewed / Open Access
• [Journal Article] Management of brain metastasis with magnetic resonance imaging and stereotactic irradiation attenuated benefits of prophylactic cranial irradiation in patients with limited-stage small cell lung cancer. (2015)
  • Author(s): Ozawa Y, Omae M, Fujii M, Matsui T, Kato M, Sagisaka S, Asada K, Karayama M, Shirai T, Yasuda K, Nakamura Y, Inui N, Yamada K, Yokomura K, Suda T.
  • Journal Title: BMC Cancer. Volume: 15 Issue: 1 Pages: 589-589
  • DOI: 10.1186/s12885-015-1593-2
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] Prognostic significance of histopthologic features in rheumatoid lung disease (2017)
  • Author(s): Nakamura Y，Colby T，Kono M，Enomoto N，Oyama Y，Enomoto Y，Mori K，Hozumi H，Suzuki Y，Karayama M，Furuhashi K，Fujisawa T，Inui N，Baba S，Miura K，Suda T
  • Organizer: American Thoracic Society International Conference 2017
  • Int'l Joint Research
• [Presentation] Distinct regulations of CD163+ macrophages and indoleamine 2,3-dioxygenase in lung cancer and infectious disease (2017)
  • Author(s): Suzuki Y，Kono M，Hozumi H，Karayama M，Furuhashi K，Enomoto N，Fujisawa T，Nakamura Y，Inui N，Suda T
  • Organizer: American Thoracic Society International Conference 2017
  • Int'l Joint Research
• [Presentation] YKL-40 is a useful biomarker for evaluating disease activity and predicting prognosis in patients with polymyositis/dermatomyositis-associated interstial lung disease (2017)
  • Author(s): Hozumi H，Fujisawa T，Kono M，Suzuki Y，Karayama M，Furuhashi K，Enomoto N，Inui N，Nakamura Y，Suda T
  • Organizer: American Thoracic Society International Conference 2017
  • Int'l Joint Research
• [Presentation] Type-1 Polarized Dendritic Cells Pulsed with ESAT-6 Are a Potent Immunogen Against Tuberculosis (2016)
  • Author(s): Satake Y, Nakamura Y, Kono M, Hozumi H, Nagata T, Tsujimura K, Enomoto N, Fujisawa T, Inui N, Yokomura K, Hayakawa H, Suda T
  • Organizer: 112 th American Thoracic Society International Conference
  • Place of Presentation: San Fransisco (USA)
  • Year and Date: 2016-05-13
  • Int'l Joint Research
• [Presentation] Analysis of Serum Ferritin in Patients with Acute Exacerbation of Idiopathic Pulmonary Fibrosis (2016)
  • Author(s): Enomoto N, Enomoto Y, Oyama Y, Kono M, Suzuki Y, Furuhashi K, Fujisawa T, Inui N, Nakamura Y, Suda T
  • Organizer: 112 th American Thoracic Society International Conference
  • Place of Presentation: San Fransisco (USA)
  • Year and Date: 2016-05-13
  • Int'l Joint Research
• [Presentation] Clinical Features and Predictive Factors for Long-Term Follow-Up in Polymyositis/Dermatomyositis-Associated Interstitial Lung Diseases (2016)
  • Author(s): ujisawa T, Hozumi H, Kono M, Enomoto N, Nakamura Y, Inui N, Nakashima R, Imura Y, Mimori T, Suda T
  • Organizer: 112 th American Thoracic Society International Conference
  • Place of Presentation: San Fransisco (USA)
  • Year and Date: 2016-05-13
  • Int'l Joint Research
• [Presentation] Dendritic Cell based Vaccines: Current Status for Cancer Immunotherapy and Application for Infectious Diseases (2015)
  • Author(s): Nakamura Y
  • Organizer: The 15th Hamamatsu-Kyungpook Joint Medical Symposium
  • Place of Presentation: Daegu, Korea
  • Year and Date: 2015-10-06
• [Presentation] Idiopathic Pleuroparenchymal Fibroelastosis: Possibility of Making a Diagnosis without Surgical Lung Biopsy (2015)
  • Author(s): Nakamura Y, Y. Satak Y, Johkoh. T, Sumikawa H, Hozumi H, , Kusagaya H, Oyama Y, Kono M, Enomoto N, Fujisawa T, Inui N, Colby TV, Suda T
  • Organizer: 111 th American Thoracic Society International Conference
  • Place of Presentation: Denver, USA
  • Year and Date: 2015-05-17
  • Int'l Joint Research