| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2019: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2018: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
In airway epithelium, EMT was transient in both cadherin expression and cytokines' effect on smooth muscle cell hypertrophy, proliferation, and contractile response. We investigated the synergistic effects of cytokines to stabilize these effects and found that IL-13 and IL-17A had a synergistic effect in increasing smooth muscle contractility and that this effect also resulted in prolongation of RhoA mRNA survival (manuscript in preparation). In addition, RhoA must be activated by phosphorylation, and we observed sustained phosphorylation of RhoA via PKC-a by IL-17A, suggesting the possibility of a transition from EMT to remodeling under cytokine stimulation and a synergistic effect within the cytokine network that is more similar to real pathological conditions. The results suggest a possible transition from EMT to remodeling under cytokine stimulation and a synergistic effect within the cytokine network(in preparation for submission for publication).
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