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EMT in bronchial asthma

Research Project

Project/Area Number 15K09225
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Respiratory organ internal medicine
Research InstitutionYokohama City University

Principal Investigator

Kudo Makoto  横浜市立大学, 附属市民総合医療センター, 准教授 (80405000)

Project Period (FY) 2015-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2019: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2018: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords気管支平滑筋 / 気管支喘息 / EMT / 上皮間葉転換 / 気道平滑筋 / 気道上皮細胞 / インてテグリン / インテグリン
Outline of Final Research Achievements

In airway epithelium, EMT was transient in both cadherin expression and cytokines' effect on smooth muscle cell hypertrophy, proliferation, and contractile response. We investigated the synergistic effects of cytokines to stabilize these effects and found that IL-13 and IL-17A had a synergistic effect in increasing smooth muscle contractility and that this effect also resulted in prolongation of RhoA mRNA survival (manuscript in preparation). In addition, RhoA must be activated by phosphorylation, and we observed sustained phosphorylation of RhoA via PKC-a by IL-17A, suggesting the possibility of a transition from EMT to remodeling under cytokine stimulation and a synergistic effect within the cytokine network that is more similar to real pathological conditions. The results suggest a possible transition from EMT to remodeling under cytokine stimulation and a synergistic effect within the cytokine network(in preparation for submission for publication).

Academic Significance and Societal Importance of the Research Achievements

This EMT phenomenon could be the mechanism in bronchial asthma severity. The patient with severe asthma could reduce their severity and this phenomenon could be new target of asthma treatment.

Report

(9 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report
  • 2016 Research-status Report
  • 2015 Research-status Report

URL: 

Published: 2015-04-16   Modified: 2024-01-30  

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