Precision medicine based on matabolic pathways in lung cancer

• Project/Area Number: 15K09229
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Respiratory organ internal medicine
• Research Institution: Keio University
• Principal Investigator: Soejima Kenzo 慶應義塾大学, 医学部(信濃町), 教授 (30236145)
• Co-Investigator(Kenkyū-buntansha): 浜本 純子 慶應義塾大学, 医学部(信濃町), 特任助教 (40570239) ; 安田 浩之 慶應義塾大学, 医学部(信濃町), 講師 (70365261)
• Co-Investigator(Renkei-kenkyūsha): HISHIKI Takako 慶應義塾大学, 医学部, 講師 (10338022)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: がん代謝 / メタボローム解析 / 肺がん / Imaging MS / 高濃度酸素暴露 / Bevacizumab / Nintedanib / AMPK / メタボロミクス / ゲノミクス / バイオバンク / イメージングマススペクトロメトリ / ドライバーがん遺伝子 / EGFR / EML4-ALK / KRAS / トランスレーショナルリサーチ / 代謝因子 / 薬剤感受性

Outline of Final Research Achievements

Comprehensive analysis of metabolic pattern in lung cancer tissues and normal tissues using capillary electrophoresis-mass spectrometry (CE-MS) and imaging MS revealed that metabolites derived from glycolysis such as lactate, nucleic acid metabolites and branched chain amino acids were increased in the cancer tissues compared to the normal counterparts. Visualization of metabolites distribution by imaging MS revealed that 2 different kind of anti-angiogenic inhibitors, namely bevacizumab and nintedanib demonstrated distinct metabolic patterns despite both showed potent anti-tumor effect. We also identified anti-tumor effect of hyperoxia in lung cancer cell lines via activation of AMPK pathway, suggesting the possibility of clinical application of exposure to hyperoxia in lung cancer patients.

Research Products

• [Journal Article] Real-world Efficacy and Safety of Nivolumab for Advanced Non?Small-cell Lung Cancer: A Retrospective Multicenter Analysis (2018)
  • Author(s): Kobayashi Keigo、Nakachi Ichiro、Naoki Katsuhiko、Satomi Ryosuke、Nakamura Morio、Inoue Takashi、Tateno Hiroki、Sakamaki Fumio、Sayama Koichi、Terashima Takeshi、Koh Hidefumi、Abe Takayuki、Nishino Makoto、Arai Daisuke、Yasuda Hiroyuki、Kawada Ichiro、Soejima Kenzo、Betsuyaku Tomoko
  • Journal Title: Clinical Lung Cancer Volume: 19 Issue: 3 Pages: e349-e358
  • DOI: 10.1016/j.cllc.2018.01.001
  • Peer Reviewed / Open Access
• [Journal Article] Intermittent Exposure to Cigarette Smoke Increases Lung Tumors and the Severity of Emphysema More Than Continuous Exposure. (2018)
  • Author(s): Kameyama N, Chubachi S, Hegab AE, Yasuda H, Kagawa S, Tsutsumi A, Fukunaga K, Shimoda M, Kanai Y, Soejima K, Betsuyaku T.
  • Journal Title: Am J Respir Cell Mol Biol. Volume: Epub ahead of print Issue: 2 Pages: 179-188
  • DOI: 10.1165/rcmb.2017-0375oc
  • Peer Reviewed
• [Journal Article] Pharmacological and Structural Characterizations of Naquotinib, a Novel Third-Generation EGFR Tyrosine Kinase Inhibitor, in EGFR-Mutated Non-Small Cell Lung Cancer. (2018)
  • Author(s): Hirano T, Yasuda H, Hamamoto J, Nukaga S, Masuzawa K, Kawada I, Naoki K, Niimi T, Mimasu S, Sakagami H, Soejima K, Betsuyaku T
  • Journal Title: Mol Cancer Ther Volume: 17(4) Issue: 4 Pages: 740-750
  • DOI: 10.1158/1535-7163.mct-17-1033
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Targeted therapy-induced facial skin toxicities: Impact on quality of life in cancer patients (2018)
  • Author(s): Yagasaki Kaori、Komatsu Hiroko、Soejima Kenzo、Naoki Katsuhiko、Kawada Ichiro、Yasuda Hiroyuki、Hamamoto Yasuo
  • Journal Title: Asia-Pacific Journal of Oncology Nursing Volume: 2 Issue: 2 Pages: 172-177
  • DOI: 10.4103/apjon.apjon_74_17
  • Peer Reviewed / Open Access
• [Journal Article] Tumor associated macrophages support the growth of FGF9-induced lung adenocarcinoma by multiple mechanisms. (2018)
  • Author(s): Hegab AE, Ozaki M, Kagawa S, Hamamoto J, Yasuda H, Naoki K, Soejima K, Yin Y, Kinoshita T, Yaguchi T, Kawakami Y, Ornitz DM, Betsuyaku T
  • Journal Title: Lung Cancer Volume: 119 Pages: 25-35
  • DOI: 10.1016/j.lungcan.2018.02.015
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Overcoming EGFR Bypass Signal-Induced Acquired Resistance to ALK Tyrosine Kinase Inhibitors in ALK-Translocated Lung Cancer. (2017)
  • Author(s): Miyawaki M, Yasuda H, Tani T, Hamamoto J, Arai D, Ishioka K, Ohgino K, Nukaga S, Hirano T, Kawada I, Naoki K, Hayashi Y, Betsuyaku T, Soejima K.
  • Journal Title: Ｍｏｌｅｃｕｌａｒ Ｃａｎｃｅｒ Ｒｅｓｅａｒｃｈ Volume: 15(1） Issue: 1 Pages: 106-114
  • DOI: 10.1158/1541-7786.mcr-16-0211
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Osimertinib for EGFR T790M Mutation-Positive Non-Small Cell Lung Cancer. (2017)
  • Author(s): Soejima K, Yasuda H, Hirano T
  • Journal Title: Expert Rev Clin Pharmacol Volume: 10 Issue: 1 Pages: 31-38
  • DOI: 10.1080/17512433.2017.1265446
  • Peer Reviewed
• [Journal Article] Amplification of EGFR Wild-Type Alleles in Non-Small Cell Lung Cancer Cells Confers Acquired Resistance to Mutation-Selective EGFR Tyrosine Kinase Inhibitors. (2017)
  • Author(s): Nukaga S, Yasuda H, Tsuchihara K, Hamamoto J, Masuzawa K, Kawada I, Naoki K, Matsumoto S, Mimaki S, Ikemura S, Goto K, Betsuyaku T, Soejima K.
  • Journal Title: Ｃａｎｃｅｒ Ｒｅｓｅａｒｃｈ Volume: 77（８） Issue: 8 Pages: 2078-2089
  • DOI: 10.1158/0008-5472.can-16-2359
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Effects of the common polymorphism in the human aldehyde dehydrogenase 2 (ALDH2) gene on the lung (2017)
  • Author(s): Kuroda Aoi、Hegab Ahmed E.、Jingtao Gao、Yamashita Shuji、Hizawa Nobuyuki、Sakamoto Tohru、Yamada Hideyasu、Suzuki Satoshi、Ishii Makoto、Namkoong Ho、Asakura Takanori、Ozaki Mari、Yasuda Hiroyuki、Hamamoto Junko、Kagawa Shizuko、Soejima Kenzo、Betsuyaku Tomoko
  • Journal Title: Respir Res Volume: 18 Issue: 1 Pages: 69-69
  • DOI: 10.1186/s12931-017-0554-5
  • NAID: 120007129115
  • Peer Reviewed / Open Access
• [Journal Article] A prospective cohort study of patients with non-squamous non-small cell lung cancer treated with bevacizumab. (2017)
  • Author(s): Naoki K, Takeda Y, Soejima K, Arai D, Naka G, Nagase S, Arimura K, Kanemura T, Ohhira T and Ikeda N
  • Journal Title: Oncology Letters Volume: 13 Issue: 5 Pages: 3285-3290
  • DOI: 10.3892/ol.2017.5796
  • Peer Reviewed
• [Journal Article] Erlotinib as second- or third-line treatment in elderly patients with advanced non-small cell lung cancer: Keio Lung Oncology Group Study 001 (KLOG001). (2017)
  • Author(s): Miyawaki M, Naoki K, Yoda S, Nakayama S, Satomi R, Sato T, Ikemura S, Ohgino K, Ishioka K, Arai D, Namkoong H, Otsuka K, Miyazaki M, Tani T, Kuroda A, Nishino M, Yasuda H, Kawada I, Koh H, Nakamura M, Terashima T, Sakamaki F, Sayama K, Betsuyaku T, Soejima K
  • Journal Title: Mol Clin Oncol Volume: 6 Issue: 3 Pages: 409-414
  • DOI: 10.3892/mco.2017.1154
  • Peer Reviewed
• [Journal Article] Clinical and pathological characteristics of EGFR mutation in operable early-stage lung adenocarcinoma (2017)
  • Author(s): Yotsukura M, Yasuda H, Shigenobu T, Kaseda K, Masai K, Hayashi Y, Hishida T, Ohtsuka T, Naoki K, Soejima K, Betsuyaku T, Asamura H
  • Journal Title: Lung Cancer Volume: 109 Pages: 45-51
  • DOI: 10.1016/j.lungcan.2017.04.014
  • Peer Reviewed
• [Journal Article] Radiologic features of precancerous areas of the lungs in chronic obstructive pulmonary disease. (2017)
  • Author(s): Chubachi S, Takahashi S, Tsutsumi A, Kameyama N, Sasaki M, Naoki K, Soejima K, Nakamura H, Asano K, Betsuyaku T
  • Journal Title: Int J Chron Obstruct Pulmon Dis Volume: 12 Pages: 1613-1624
  • DOI: 10.2147/copd.s132709
  • Peer Reviewed
• [Journal Article] Variant CD44 expression is enriching for a cell population with cancer stem cell-like characteristics in human lung adenocarcinoma. (2017)
  • Author(s): Nishino M, Ozaki M, Hegab AE, Hamamoto J, Kagawa S, Arai D, Yasuda H, Naoki K, Soejima K, Saya H, Betsuyaku T
  • Journal Title: J Cancer Volume: 8 Issue: 10 Pages: 1774-1785
  • DOI: 10.7150/jca.19732
  • Peer Reviewed
• [Journal Article] Non-small cell lung cancer PC-9 cells exhibit increased sensitivity to gemcitabine and vinorelbine upon acquiring resistance to EGFR-tyrosine kinase inhibitors. (2017)
  • Author(s): Hamamoto J, Yasuda H, Aizawa K, Nishino M, Nukaga S, Hirano T, Kawada I, Naoki K, Betsuyaku T, Soejima K.
  • Journal Title: Oncol Lett. Volume: 14(3) Issue: 3 Pages: 3559-3565
  • DOI: 10.3892/ol.2017.6591
  • Peer Reviewed
• [Journal Article] Characterization of the efficacies of osimertinib and nazartinib against cells expressing clinically relevant epidermal growth factor receptor mutations. (2017)
  • Author(s): Masuzawa K, Yasuda H, Hamamoto J, Nukaga S, Hirano T, Kawada I, Naoki K, Soejima K, Betsuyaku T.
  • Journal Title: Oncotarget. Volume: 8(62) Issue: 62 Pages: 105479-105491
  • DOI: 10.18632/oncotarget.22297
  • Peer Reviewed / Open Access
• [Journal Article] Development of an S-1 dosage formula based on renal function by a prospective pharmacokinetic study (2016)
  • Author(s): Booka E, Imamura CK, Takeuchi H, Hamamoto Y, Gomi D, Mizukami T, Ichiyama T, Tateishi K, Takahashi T, Kawakubo H, Soejima K, Boku N, Tanigawara Y, Kitagawa Y
  • Journal Title: Gastric Cancer Volume: 19 Issue: 3 Pages: 876-86
  • DOI: 10.1007/s10120-015-0536-6
  • NAID: 40020881776
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] In vitro modeling to determine mutation specificity of EGFR tyrosine kinase inhibitors against clinically relevant EGFR mutants in non-small-cell lung cancer (2016)
  • Author(s): Hirano T, Yasuda H, Tani T, Hamamoto J, Oashi A, Ishioka K, Arai D, Nukaga S, Miyawaki M, Kawada I, Naoki K, Costa DB, Kobayashi SS, BetsuyakuT, Soejima K
  • Journal Title: Oncotarget Volume: 17 Issue: 36 Pages: 38789-803
  • DOI: 10.18632/oncotarget.5887
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Activation of EGFR bypass signaling by TGFα overexpression induces acquired resistance to alectinib in ALK-translocated lung cancer cells (2016)
  • Author(s): Tani T, Yasuda H, Hamamoto J, Kuroda A, Arai D, Ishioka K, Ohgino K, Miyawaki M, Kawada I, Naoki K, Hayashi Y, Betsuyaku T, Soejima K
  • Journal Title: Mol Cancer Ther Volume: 15 Pages: 162-71
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] A phase II study of S-1 and irinotecan combination therapy in previously treated patients with advanced non-small cell lung cancer (2015)
  • Author(s): Ikemura S, Naoki K, Yasuda H, Kawada I, Yoda S, Terai H, Sato T, Ishioka K, Arai D, Ohgino K, Kamata H, Miyata J, Kabata H, Betsuyaku T and Soejima K
  • Journal Title: Jpn J Clin Oncol Volume: 45 Issue: 4 Pages: 356-61
  • DOI: 10.1093/jjco/hyu226
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] A phase II study of biweekly paclitaxel and carboplatin in elderly patients with advanced non-small cell lung cancer. (2015)
  • Author(s): Soejima K, Naoki K, Ishioka K, Nakamura M, Nakatani R, Kawada I, Watanabe H, Nakachi I, Yasuda H, Satomi R, Nakayama S, Yoda S, Ikemura S, Terai H, Sato T, Ohgino K, Arai D and Betsuyaku T
  • Journal Title: Cancer Chemother Pharmacol Volume: 75 Issue: 3 Pages: 513-9
  • DOI: 10.1007/s00280-014-2673-8
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Mimicking the niche of lung epithelial stem cells and characterization of several effectors of their in vitro behavior (2015)
  • Author(s): Hegab AE, Arai D, Gao J, Kuroda A, Yasuda H, Ishii M, Naoki K, Soejima K, Betsuyaku T
  • Journal Title: Stem Cell Res Volume: 15 Issue: 1 Pages: 109-121
  • DOI: 10.1016/j.scr.2015.05.005
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Prognostic implication of PTPRH hypomethylation in non-small cell lung cancer (2015)
  • Author(s): Sato T, Soejima K, Arai E, Hamamoto J, Yasuda H, Arai D, Ishioka K, Ohgino K, Naoki K, Kohno T, Tsuta K, Watanabe S, Kanai Y and Betsuyaku T
  • Journal Title: Oncol Rep Volume: 34 Issue: 3 Pages: 1137-45
  • DOI: 10.3892/or.2015.4082
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] The reasons for triple therapy in stable COPD patients in Japanese clinical practice (2015)
  • Author(s): Miyazaki M, Nakamura H, Takahashi S, Chubachi S, Sasaki M, Haraguchi M, Terai H, Ishii M, Fukunaga K, Tasaka S, Soejima K, Asano K, Betsuyaku T
  • Journal Title: Int J Chron Obstruct Pulmon Dis Volume: 10 Pages: 1053-9
  • DOI: 10.2147/copd.s79864
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Characterization of the cell of origin and propagation potential of the fibroblast growth factor 9-induced mouse model of lung adenocarcinoma (2014)
  • Author(s): Arai D, Hegab AE, Soejima K, Kuroda A, Ishioka K, Yasuda H, Naoki K, KagawaS, Hamamoto J, Yin Y, Ornitz DM, Betsuyaku T S,
  • Journal Title: J Pathol Volume: 235 Issue: 4 Pages: 593-605
  • DOI: 10.1002/path.4486
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] In vitro characterization of the effect of nazartinib against clinically relevant EGFR mutants. (2017)
  • Author(s): Keita Masuzawa, Hiroyuki Yasuda, Junko Hamamoto, Toshiyuki Hirano, Shigenari Nukaga, Hanako Hasegawa, Tetsuo Tani, Ichiro Kawada, Katsuhiko Naoki, Kenzo Soejima, Tomoko Betsuyaku
  • Organizer: 107th AACR Annual Meeting, Washington DC
  • Int'l Joint Research
• [Presentation] EGFR wild type allele amplification induces acquired resistance to mutation-specific EGFR tyrosine kinase inhibitors in non-small cell lung cancer cells. (2017)
  • Author(s): Keigo Kobayashi, Shigenari Nukaga, Hiroyuki Yasuda, Keita Masuzawa, Jyunko Hamamoto, Ichiro Kawada, Katsuhiko Naoki, Sachiyo Mimaki, Shingo Matsumoto, Koichi Goto, Katsuya Tsuchihara, Tomoko Betsuyaku, Kenzo Soejima
  • Organizer: 107th AACR Annual Meeting, Washington DC
  • Int'l Joint Research
• [Presentation] Discussion MA 06-Lung Cancer Biology I MA 06.06-MA 06.09 (2017)
  • Author(s): Kenzo Soejima
  • Organizer: IASLC 18th WCLC, Yokohama
  • Int'l Joint Research / Invited
• [Presentation] Practical effectiveness and safety of Nivolumab on advanced non-small cell lung cancer: a multi center analysis. (2017)
  • Author(s): Keigo Kobayashi, Ichiro Nakachi, Katsuhiko Naoki, Yoshitaka Oyamada, Morio Nakamura, Takashi Inoue, Hiroki Tateno, Fumio Sakamaki, Koichi Sayama, Tsuyoshi Terashima, Hidefumi Koh, Makoto Nishino, Daisuke Arai, Hiroyuki Yasuda, Ichiro Kawada, Kenzo Soejima, Tomoko Betsuyaku
  • Organizer: ESMO 2017 Congress, Madrid
  • Int'l Joint Research
• [Presentation] 各種EGFR遺伝子変異に対するEGF816の効果. (2017)
  • Author(s): 増澤啓太、安田浩之、長谷川華子、額賀重成、平野俊之、西野誠、川田一郎、猶木克彦、副島研造、別役智子
  • Organizer: 第57回日本呼吸器学会学術総会、東京
• [Presentation] 当院におけるEGFR 遺伝子変異陽性非小細胞肺癌に対する re-biopsy の検討. (2017)
  • Author(s): 増澤啓太、安田浩之、小林慧悟、眞鍋維志、長谷川華子、平野俊之、額賀重成、西野誠、川田一郎、猶木克彦、副島研造、別役智子
  • Organizer: 第40回日本呼吸器内視鏡学会学術集会、長崎
• [Presentation] Evaluation of the distinct effect of anti-angiogenic agents, nintedanib and bevacizumab in lung cancer on metabolism. (2017)
  • Author(s): 増澤啓太、荒井大輔、安田浩之、長谷川華子、額賀重成、平野俊之、川田一郎、猶木克彦、副島研造、別役智子
  • Organizer: 第76回日本癌学会学術集会、横浜
• [Presentation] 進行非小細胞肺癌EGFR-TKI治療後再生検での組織およびliquid biopsyによるEGFR T790M検出 (2017)
  • Author(s): 眞鍋維志、小林慧悟、猶木克彦、長谷川華子、増澤啓太、平野俊之、額賀重成、西野誠、安田浩之、川田一郎、副島研造、別役智子
  • Organizer: 第57回日本呼吸器学会学術総会、東京
• [Presentation] 実臨床での進行非小細胞肺癌142例に対するニボルマブの効果（多施設共同症例集積研究） (2017)
  • Author(s): 小林慧悟、猶木克彦、西野誠、谷哲夫、扇野圭子、浅見貴弘、里見良輔、安田浩之、川田一郎、仲地一郎、黄英文、舘野博喜、井上卓、西尾和三、中村守男、小山田吉孝、坂巻文雄 、佐山宏一、副島研造、別役智子
  • Organizer: 第57回日本呼吸器学会学術総会、東京
• [Presentation] 高濃度酸素が肺癌の増殖に与える影響とその分子メカニズム (2017)
  • Author(s): 浜本純子，副島研造，安田浩之，仲地一郎，長谷川華子，増澤啓太，小林慧悟, 眞鍋維志，川田一郎，猶木克彦，別役智子
  • Organizer: 第58回日本肺癌学会総会、横浜
• [Presentation] 悪性胸膜中皮腫におけるMET阻害剤， PI3K/mTOR二重阻害剤とその併用効果 (2017)
  • Author(s): 川田一郎， Rajani Kanteti， Immanuel Dhanasingh， Frances E. Lennon， Qudsia Arif， Rifat Hasina， Aliya N. Husain， Tanguy Seiwert， Hedy L. Kindler， Ravi Salgia， 別役智子， 副島研造
  • Organizer: 第58回日本肺癌学会総会、横浜
• [Presentation] 高濃度酸素が肺癌の増殖に与える影響とその分子メカニズム (2016)
  • Author(s): 浜本純子，副島研造，安田浩之，仲地一郎，長谷川華子，増澤啓太，小林慧悟, 眞鍋維志，川田一郎，猶木克彦，別役智子
  • Organizer: 日本肺癌学会学術集会
  • Place of Presentation: 福岡国際会議場（福岡県福岡市）
  • Year and Date: 2016-12-19
• [Presentation] 悪性胸膜中皮腫におけるMET阻害剤， PI3K/mTOR二重阻害剤とその併用効果 (2016)
  • Author(s): 川田一郎， Rajani Kanteti， Immanuel Dhanasingh， Frances E. Lennon， Qudsia Arif， Rifat Hasina， Aliya N. Husain， Tanguy Seiwert， Hedy L. Kindler， Ravi Salgia， 別役智子， 副島研造
  • Organizer: 日本肺癌学会学術集会
  • Place of Presentation: 福岡国際会議場（福岡県福岡市）
  • Year and Date: 2016-12-19
• [Presentation] Visualizing the distribution of metabolites and the efficacy of BIBF1120 on metabolic status of lung cancer derived tumors by imaging mass-spectrometry (MS) (2016)
  • Author(s): Daisuke Arai, Hiroyuki Yasuda, Kenzo Soejima, Shizuko Kagawa, Junko Hamamoto, Shigenari Nukaga1, Katsuhiko Naoki, Katsura Emoto, Yuki Sugiura, Makoto Suematsu, Tomoko Betsuyaku
  • Organizer: American Association for Cancer Research (AACR) Annual Meeting
  • Place of Presentation: New Orleans, USA
  • Year and Date: 2016-04-16
  • Int'l Joint Research
• [Presentation] Evaluation of multiple EGFR tyrosine kinase inhibitors against clinically relevant EGFR mutants using in vitro modeling. (2016)
  • Author(s): Hanako Hasegawa, Hiroyuki Yasuda, Toshiyuki Hirano, Tetsuo Tani, Junko Yamamoto, Ayano Oashi, Ichiro Kawada, Katsuhiko Naoki, Daniel B. Costa, Susumu S. Kobayashi, Tomoko Betsuyaku, Kenzo Soejima
  • Organizer: American Association for Cancer Research (AACR) Annual Meeting
  • Place of Presentation: New Orleans, USA
  • Year and Date: 2016-04-16
  • Int'l Joint Research
• [Presentation] PTPRH Hypomethylation as a Prognostic Factor in Non-Small Cell Lung Cancer (2015)
  • Author(s): Takashi Sato, Kenzo Soejima, Eri Arai, Junko Hamamoto, Hiroyuki Yasuda, Daisuke Arai, Kota Ishioka, Keiko Ohgino, Katsuhiko Naoki, Takashi Kohno, Koji Tsuta, Shun-Ichi Watanabe, Yae Kanai, Tomoko Betsuyaku
  • Organizer: 16TH WORLD CONFERENCE ON LUNG CANCER
  • Place of Presentation: Denver, USA
  • Year and Date: 2015-09-06
  • Int'l Joint Research
• [Presentation] ABT-263 is effective in a subset of non-small cell lung cancer cell lines (2015)
  • Author(s): Aoi Kuroda, Keiko Ohgino, Hiroyuki Yasuda, Junko Hamamoto, Daisuke Arai, Kota Ishioka, Tetsuo Tani, Shigenari Nukaga, Ichiro Kawada, Katsuhiko Naoki, Kenzo Soejima, Tomoko Betsuyaku
  • Organizer: American Association for Cancer Research (AACR) Annual Meeting
  • Place of Presentation: Philadelphia, USA
  • Year and Date: 2015-04-18
  • Int'l Joint Research
• [Presentation] Activation of EGFR bypass signaling through TGFα overexpression induces acquired resistance to alectinib in ALK-translocated lung cancer cells (2015)
  • Author(s): Tetsuo Tani, Hiroyuki Yasuda, Junko Hamamoto, Aoi Kuroda, Daisuke Arai, Kota Ishioka, Keiko Ohgino, Ichiro Kawada, Katsuhiko Naoki, Hayashi Yuichiro, Tomoko Betsuyaku, Kenzo Soejima
  • Organizer: AACR Annual Meeting
  • Place of Presentation: Philadelphia, USA
  • Year and Date: 2015-04-18
  • Int'l Joint Research
• [Presentation] Visualizing the effect of BIBF1120 in lung cancer cells by imaging-massspectrometry (MS) (2015)
  • Author(s): Daisuke Arai, Kenzo Soejima, Hiroyuki Yasuda, Kota Ishioka, Shizuko Kagawa, Junko Hamamoto, Katsuhiko Naoki, Katsura Emoto, Yuki Sugiura, Makoto Suematsu, Tomoko Betsuyaku
  • Organizer: AACR Annual Meeting
  • Place of Presentation: Philadelphia, USA
  • Year and Date: 2015-04-18
  • Int'l Joint Research
• [Presentation] Hyperoxia may be a treatment option for NSCLC (2015)
  • Author(s): Junko Hamamoto, Hiroyuki Yasuda, Ichiro Nakachi, Michael G. Edwards, Masayoshi Miyawaki, Makoto Nishino, Aoi Kuroda, Tetsuo Tani, Daisuke Arai, Kota Ishioka, Ichiro Kawada, Katsuhiko Naoki, Tomoko Betsuyaku, Kenzo Soejima
  • Organizer: AACR Annual Meeting
  • Place of Presentation: Philadelphia, USA
  • Year and Date: 2015-04-18
  • Int'l Joint Research
• [Presentation] Oncogenic potential of FGF9 in lung cancer (2015)
  • Author(s): Kota Ishioka, Kenzo Sejima, Hiroyuki Yasuda, Junko Hamamoto, Ahmed Hegab, Tetsuo Tani, Aoi Kuroda, Daisuke Arai, Keiko Ohgino, Takashi Sato, Terai Hideki, Ichiro Kawada, Katsuhiko Naoki, Yuichiro Hayashi, Tomoko Betsuyaku
  • Organizer: AACR Annual Meeting
  • Place of Presentation: Philadelphia, USA
  • Year and Date: 2015-04-18
  • Int'l Joint Research