Study on the refractory mechanism in inflammatory obstructive lung disease

• Project/Area Number: 15K09233
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Respiratory organ internal medicine
• Research Institution: Jikei University School of Medicine
• Principal Investigator: Nakayama Katsutoshi 東京慈恵会医科大学, 医学部, 准教授 (40321989)
• Co-Investigator(Renkei-kenkyūsha): Kaneko Yumi 東京慈恵会医科大学, 医学部, 准教授 (50646669) ; Araya Jun 東京慈恵会医科大学, 医学部, 准教授 (90468679)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 慢性閉塞性肺疾患 / 気管支喘息 / 難治化 / ヒト ヘルペス ウイルス / 抗SITH-1抗体 / 術後肺合併症 / 好酸球性副鼻腔炎 / 喘息 / COPD / 術後合併症 / ACOS / 疲労 / HHV-6 / HHV-7 / SITH-1

Outline of Final Research Achievements

To evaluate fatigue as a mechanism of COPD and asthma refractory, salivary HHV-6/-7 titer and blood SITH-1 Ab titer were examined. More than 30% of COPD or asthma patients showed high viral titer. Especially, the proportion of patients with high HHV-7 tended to increase with symptoms severity. In addition, the positive rate (%) of SITH-1 Ab was significantly higher in COPD or asthma patients than in healthy subjects. Furthermore, in asthmatic patients, SITH-1 Ab (+) was involved in symptom severity and exacerbation risk.
We also examined the risk factors of postoperative pulmonary complications (PPC) in COPD or asthma patients. History of heavy smoking and high severity were associated with increased PPC risk in asthma. Aging, long operation or operation in abdomen were associated with PPC risk in COPD. Meanwhile, ICS therapy in eosinophilic asthma and introduction of standard therapy in COPD was shown to contribute to PPC reduction.

Research Products

• [Journal Article] Risk factors of postoperative pulmonary complications in patients with asthma and COPD. (2018)
  • Author(s): Numata T, Nakayama K, Fujii S, Yumino Y, Saito N, Yoshida M, Kurita Y, Kobayashi K, Ito S, Utsumi H, Yanagisawa H, Hashimoto M, Wakui H, Minagawa S, Ishikawa T, Hara H, Araya J, Kaneko Y, Kuwano K.
  • Journal Title: BMC Pulm Med. Volume: 18 Issue: 1 Pages: 1-8
  • DOI: 10.1186/s12890-017-0570-8
  • Peer Reviewed / Open Access
• [Journal Article] Detection of pathogens by real-time PCR in adult patients with acute exacerbation of bronchial asthma. (2017)
  • Author(s): Yoshii Y, Shimizu K, Morozumi M, Chiba N, Ubukata K, Uruga H, Hanada S, Wakui H, Minagawa S, Hara H, Numata T, Saito K, Araya J, Nakayama K, Kishi K, Kuwano K.
  • Journal Title: BMC Pulm Med. Volume: 17 Issue: 1
  • DOI: 10.1186/s12890-017-0494-3
  • Peer Reviewed / Open Access
• [Journal Article] Azithromycin attenuates myofibroblast differentiation and lung fibrosis development through proteasomal degradation of NOX4. (2017)
  • Author(s): Tsubouchi K, Araya J, Minagawa S, Hara H, Ichikawa A, Saito N, Kadota T, Sato N, Yoshida M, Kurita Y, Kobayashi K, Ito S, Fujita Y, Utsumi H, Yanagisawa H, Hashimoto M, Wakui H, Yoshii Y, Ishikawa T, Numata T, Kaneko Y, Asano H, Yamashita M, Odaka M, Morikawa T, Nakayama K, Nakanishi Y, Kuwano K.
  • Journal Title: Autophagy Volume: 13(8) Issue: 8 Pages: 1420-1434
  • DOI: 10.1080/15548627.2017.1328348
  • Peer Reviewed
• [Journal Article] Pirfenidone inhibits myofibroblast differentiation and lung fibrosis development during insufficient mitophagy. (2017)
  • Author(s): Kurita Y, Araya J, Minagawa S, Hara H, Ichikawa A, Saito N, Kadota T, Tsubouchi K, Sato N, Yoshida M, Kobayashi K, Ito S, Fujita Y, Utsumi H, Yanagisawa H, Hashimoto M, Wakui H, Yoshii Y, Ishikawa T, Numata T, Kaneko Y, Asano H, Yamashita M, Odaka M, Morikawa T, Nakayama K, Kuwano K.
  • Journal Title: Respir Res. Volume: 18(1) Issue: 1 Pages: 114-114
  • DOI: 10.1186/s12931-017-0600-3
  • Peer Reviewed / Open Access
• [Journal Article] Mild Lung Tuberculosis in a Patient Suffering from Status Epilepticus Caused by the Syndrome of Inappropriate Secretion of Antidiuretic Hormone (SIADH) (2017)
  • Author(s): Hashimoto M, Kuriiwa S, Kojima A, Shinhuku K, Sato A, Sasaki R, Hasegawa T, Ito A, Utsumi H, Yanagisawa H, Wakui H, Minagawa S, Kojima J, Numata T, Hara H, Araya J, Kaneko Y, Nakayama K, Kuwano K.
  • Journal Title: Internal Medicine Volume: 56 Issue: 4 Pages: 429-433
  • DOI: 10.2169/internalmedicine.56.7224
  • NAID: 130005345716
  • ISSN: 0918-2918, 1349-7235
  • Peer Reviewed / Open Access
• [Journal Article] 2. Increased levels of prostaglandin E-major urinary metabolite (PGE-MUM) in chronic fibrosing interstitial pneumonia. (2017)
  • Author(s): Horikiri T, Hara H, Saito N, Araya J, Takasaka N, Utsumi H, Yanagisawa H, Hashimoto M, Yoshii Y, Wakui H, Minagawa S, Ishikawa T, Shimizu K, Numata T, Arihiro S, Kaneko Y, Nakayama K, Matsuura T, Matsuura M, Fujiwara M, Okayasu I, Ito S, Kuwano K.
  • Journal Title: Respir Med. Volume: 122 Pages: 43-50
  • DOI: 10.1016/j.rmed.2016.11.017
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Macroscopic inflammatory tracheal and endobronchial nodules in Sjögren's syndrome. (2016)
  • Author(s): Hara H, Kuwano K, Minagawa S, Numata T, Araya J, Nakayama K.
  • Journal Title: Thorax. Volume: - Issue: 9 Pages: 864-865
  • DOI: 10.1136/thoraxjnl-2016-209390
  • Peer Reviewed
• [Journal Article] Cellular senescence and autophagy in the pathogenesis of chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF). (2016)
  • Author(s): Kuwano K, Araya J, Hara H, Minagawa S, Takasaka N, Ito S, Kobayashi K, Nakayama K.
  • Journal Title: Respir Investig. Volume: 54 Issue: 6 Pages: 397-406
  • DOI: 10.1016/j.resinv.2016.03.010
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Metformin attenuates lung fibrosis development via NOX4 suppression. (2016)
  • Author(s): Sato N, Takasaka N, Yoshida M, Tsubouchi K, Minagawa S, Araya J, Saito N, Fujita Y, Kurita Y, Kobayashi K, Ito S, Hara H, Kadota T, Yanagisawa H, Hashimoto M, Utsumi H, Wakui H, Kojima J, Numata T, Kaneko Y, Odaka M, Morikawa T, Nakayama K, Kohrogi H, Kuwano K.
  • Journal Title: Respir Res. Volume: 17 Issue: 1
  • DOI: 10.1186/s12931-016-0420-x
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Identification of pathogens by comprehensive real-time PCR versus conventional methods in community-acquired pneumonia in Japanese adults. (2016)
  • Author(s): Yoshii Y, Shimizu K, Morozumi M, Chiba N, Ubukata K, Uruga H, Hanada S, Wakui H, Ito S, Takasaka N, Minagawa S, Kojima J, Numata T, Hara H, Kawaishi M, Saito K, Araya J, Kaneko Y, Nakayama K, Kishi K, Kuwano K.
  • Journal Title: Infect Dis (Lond). Volume: 48 Issue: 11-12 Pages: 782-788
  • DOI: 10.1080/23744235.2016.1193788
  • Peer Reviewed
• [Journal Article] Involvement of PARK2-Mediated Mitophagy in Idiopathic Pulmonary Fibrosis Pathogenesis. (2016)
  • Author(s): Kobayashi K, Araya J, Minagawa S, Hara H, Saito N, Kadota T, Sato N, Yoshida M, Tsubouchi K, Kurita Y, Ito S, Fujita Y, Takasaka N, Utsumi H, Yanagisawa H, Hashimoto M, Wakui H, Kojima J, Shimizu K, Numata T, Kawaishi M, Kaneko Y, Asano H, Yamashita M, Odaka M, Morikawa T, Nakayama K, Kuwano K.
  • Journal Title: J Immunol. Volume: 197 Issue: 2 Pages: 504-516
  • DOI: 10.4049/jimmunol.1600265
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] 実地医家にとっての喘息とCOPDの合併(asthma-COPD overlap syndrome: ACOS) (2016)
  • Author(s): 中山 勝敏
  • Journal Title: Clinical Respiration Volume: 2 Pages: 14-17
• [Journal Article] 肺線維症発症に関連する遺伝子解析 (2016)
  • Author(s): 桑野和善, 荒屋潤, 原 弘道, 沼田尊功, 金子由美, 小島淳, 皆川俊介, 和久井大, 橋本典生, 柳澤治彦, 内海裕文, 中山勝敏.
  • Journal Title: Respiratory Medical Research Volume: 4 Pages: 31-35
• [Journal Article] Pathogens in COPD exacerbations identified by comprehensive real-time PCR plus older methods. (2015)
  • Author(s): Shimizu K, Yoshii Y, Morozumi M, Chiba N, Ubukata K, Uruga H, Hanada S, Saito N, Kadota T, Ito S, Wakui H, Takasaka N, Minagawa S, Kojima J, Hara H, Numata T, Kawaishi M, Saito K, Araya J, Kaneko Y, Nakayama K, Kishi K, Kuwano K.
  • Journal Title: Int J Chron Obstruct Pulmon Dis. Volume: 10 Pages: 2009-16
  • DOI: 10.2147/copd.s82752
  • Peer Reviewed
• [Journal Article] Clinical efficacy of anti-glycopeptidolipid-core IgA test for diagnosing Mycobacterium avium complex infection in lung. (2015)
  • Author(s): Numata T, Araya J, Yoshii Y, Shimizu K, Hara H, Nakayama K, Kuwano K.
  • Journal Title: Respirology. Volume: 20 Issue: 8 Pages: 1277-81
  • DOI: 10.1111/resp.12640
  • Peer Reviewed
• [Journal Article] Relation between recurrence of tuberculosis and transitional changes in IFN-γ release assays. (2015)
  • Author(s): Kaneko Y, Nakayama K, Kinoshita A, Kurita Y, Odashima K, Saito Z, Yoshii Y, Horikiri T, Seki A, Seki Y, Takeda H, Kuwano K.
  • Journal Title: Am J Respir Crit Care Med Volume: 191 Issue: 4 Pages: 480-483
  • DOI: 10.1164/rccm.201409-1590le
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] PARK2-mediated mitophagy is involved in regulation of HBEC senescence in COPD pathogenesis. (2015)
  • Author(s): Ito S, Araya J, Kurita Y, Kobayashi K, Takasaka N, Yoshida M, Hara H, Minagawa S, Wakui H, Fujii S, Kojima J, Shimizu K, Numata T, Kawaishi M, Odaka M, Morikawa T, Harada T, Nishimura SL, Kaneko Y, Nakayama K, Kuwano K.
  • Journal Title: Autophagy. Volume: 11 Issue: 3 Pages: 547-59
  • DOI: 10.1080/15548627.2015.1017190
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] A case of pulmonary lymphangioleiomyomatosis complicated with uterine and retroperitoneal tumors. (2015)
  • Author(s): Numata T, Araya J, Mikami J, Hara H, Harada T, Takahashi H, Nakayama K, Kuwano K.
  • Journal Title: Respir Med Case Rep. Volume: 15 Pages: 71-6
  • DOI: 10.1016/j.rmcr.2015.02.001
  • Peer Reviewed
• [Presentation] Role of lamin B1 in COPD pathogenesis. (2017)
  • Author(s): Nayuta Saito, Katsutoshi Nakayama, et al.
  • Organizer: European Respiratory Society International Congress 2017
  • Int'l Joint Research
• [Presentation] PARK2-regulated mitophagy in COPD pathogenesis. (2017)
  • Author(s): Nahoko Sato, Kazuya Tsubouchi, Jun Araya, Shunsuke Minagawa, Hiromichi Hara, Nayuta Saito, Masahiro Yoshida, Yusuke Kurita, Kenji Kobayashi, Saburo Ito, Takeo Ishikawa, Takanori Numata, Yumi Kaneko, Katsutoshi Nakayama, Hirotsugu Kohrogi, Kazuyoshi Kuwano.
  • Organizer: European Respiratory Society International Congress 2017
  • Int'l Joint Research
• [Presentation] Azithromycin-mediated CHIP regulation promotes proteasomal degradation of NOX4. (2017)
  • Author(s): Kazuya Tsubouchi, Jun Araya, Shunsuke Minagawa, Hiromichi Hara, Nayuta Saito, Akihiro Ichikawa, Nahoko Sato, Masahiro Yoshida, Yusuke Kurita, Takanori Numata, Yumi Kaneko, Katsutoshi Nakayama, Kazuyoshi Kuwano.
  • Organizer: European Respiratory Society International Congress 2017
  • Int'l Joint Research
• [Presentation] Involvement ferroptosis in COPD pathogenesis. (2017)
  • Author(s): Masahiro Yoshida (Tokyo, Japan), Shunsuke Minagawa, Jun Araya, Hiromichi Hara, Akihiro Ichikawa, Nayuta Saito, Nahoko Sato, Kazuya Tsubouchi, Yusuke Kurita, Takanori Numata, Yumi Kaneko, Katsutoshi Nakayama, Kazuyoshi Kuwano.
  • Organizer: European Respiratory Society International Congress 2017
  • Int'l Joint Research
• [Presentation] Evaluation of fatigue state with virus-related novel biomarkers in obstructive lung diseases (2016)
  • Author(s): Y. Kaneko, K. Nakayama, N. Saito, K. Tsubouchi, N. Sato, M. Yoshida, Y. Kurita, K. Kobayashi, H. Utsumi, H. Yanagisawa, Mi. Hashimoto, H. Wakui, S. Minagawa, A. Kojima, H. Hara, T. Numata, J. Araya, K. Kuwano, N. Kobayashi, K. Kondo
  • Organizer: European Respiratory Society International Congress 2016 (国際学会)
  • Place of Presentation: London, UK
  • Year and Date: 2016-09-03
  • Int'l Joint Research
• [Presentation] Risk factors of postoperative pulmonary complications in bronchial asthma and COPD patients (2016)
  • Author(s): Takanori Numata, Katsutoshi Nakayama, Nayuta Saito, Kazuya Tsubouchi, Nahoko Sato, Masahiro Yoshida, Yusuke Kurita, Kenji Kobayashi, Hirofumi Utsumi, Haruhiko Yanagisawa, Mitsuo Hashimoto, Hiroshi Wakui, Shunsuke Minagawa, Jun Kojima, Hiromichi Hara, Jun Araya, Yumi Kaneko, Kazuyoshi Kuwano
  • Organizer: European Respiratory Society International Congress 2016 (国際学会)
  • Place of Presentation: London, UK
  • Year and Date: 2016-09-03
  • Int'l Joint Research
• [Presentation] Involvement of ferroptosis in COPD pathogenesis (2016)
  • Author(s): Masahiro Yoshida (Tokyo, Japan), Masahiro Yoshida, Shunsuke Minagawa, Jun Araya, Hiromichi Hara, Nayuta Saito, Nahoko Sato, Kazuya Tsubouchi, Yusuke Kurita, Kenji Kobayashi, Saburo Ito, Takanori Numata, Yumi Kaneko, Katsutoshi Nakayama, Kazuyoshi Kuwano
  • Organizer: European Respiratory Society International Congress 2016 (国際学会)
  • Place of Presentation: London, UK
  • Year and Date: 2016-09-03
  • Int'l Joint Research
• [Presentation] Pirfenidone attenuates myofibroblast differentiation during insufficient mitophagy (2016)
  • Author(s): Yusuke Kurita, Jun Araya, Hiromiti Hara, Shunsuke Minagawa, Nayuta Saito, Nahoko Sato, Kazuya Tubouchi, Masahiro Yoshida, Kenji Kobayashi, Takanori Numata, Yumi Kaneko, Katutoshi Nakayama, Kazuyoshi Kuwano
  • Organizer: European Respiratory society international congress 2016 (国際学会)
  • Place of Presentation: London, UK
  • Year and Date: 2016-09-03
  • Int'l Joint Research
• [Presentation] Azithromycin Suppresses TGF-β-Induced Myofibroblast Differentiation By Promoting Proteasomal Degradation Of NOX4 (2016)
  • Author(s): K. Tsubouchi, J. Araya, H. Hara, S. Minagawa, N. Saito, N. Sato, M. Yoshida, Y. Kurita, K. Kobayashi, J. Kojima, T. Numata, Y. Kaneko, K. Nakayama, T. Morikawa, K. Kuwano,
  • Organizer: American Thoracic Society 2016 International Conference
  • Place of Presentation: San francisco, USA
  • Year and Date: 2016-05-13
• [Presentation] Involvement Of PARK2-Mediated Mitophagy In Idiopathic Pulmonary Fibrosis Pathogenesis (2016)
  • Author(s): Kobayashi K, Araya J, Hara H, Minagawa S, Yoshida M, Tsubouchi K, Kadota T, Saito N, Sato N, Kurita Y, Ito S, Kojima J, Numata T, Kaneko Y, Asano H, Yamashita M, Odaka M, Morikawa T, Nakayama K, Kuwano K,
  • Organizer: American Thoracic Society 2016 International Conference
  • Place of Presentation: San francisco, USA
  • Year and Date: 2016-05-13
  • Int'l Joint Research
• [Presentation] Involvement Of Lamin B1 In COPD Pathogenesis (2016)
  • Author(s): Saito N, Araya J, Ito S, Kadota T, Yoshida M, Sato N, Tsubouchi K, Kurita Y, Kobayashi K, Minagawa S, Hara H, Utsumi H, Yanagisawa H, Hashimoto M, Wakui H, Kojima J, Numata T, Kaneko Y, Morikawa T, Nakayama K, Kuwano K,
  • Organizer: American Thoracic Society 2016 International Conference
  • Place of Presentation: San francisco, USA
  • Year and Date: 2016-05-13
• [Presentation] Metformin Suppresses Myofibroblast Differentiation By Inhibition Of Nox4-Mediated Smad Signaling (2016)
  • Author(s): N. Sato, N. Takasaka, M. Yoshida, S. Minagawa, J. Araya, N. Saito, K. Tsubouchi, Y. Kurita, K. Kobayashi, H. Hara, J. Kojima, T. Numata, Y. Kaneko, K. Nakayama, T. Morikawa, K. Kuwano.
  • Organizer: American Thoracic Society 2016 International Conference
  • Place of Presentation: San francisco, USA
  • Year and Date: 2016-05-13
  • Int'l Joint Research
• [Presentation] シンポジウム７ COPDの新展開 細胞老化 (2016)
  • Author(s): 中山 勝敏
  • Organizer: 第56回日本呼吸器学会学術講演会
  • Place of Presentation: 国立京都国際会館 京都市
  • Year and Date: 2016-04-08
  • Invited
• [Presentation] Metformin Suppresses Lung Fibrosis Development By Modulating TGF-β-Induced Myofibroblast Differentiation (2015)
  • Author(s): Masahiro Yoshida, Jun Araya, Naoki Takasaka, Shunsuke Minagawa, Nahoko Sato, , Yusuke Kurita, Kenji Kobayashi, Saburo Ito, Hiroshi Wakui, Satoko Fujii, Jun Kojima, Hiromichi Hara, Kenichiro Shimizu, Takanori Numata, Makoto Kawaishi, Yumi Kaneko, Katsutoshi Nakayama, and Kazuyoshi Kuwano,
  • Organizer: American Thoracic Society 2015 International Conference
  • Place of Presentation: Ｄｅｎｖｅｒ，ＵＳＡ
  • Year and Date: 2015-05-15
  • Int'l Joint Research
• [Presentation] Involvement Of Platelet-Derived Growth Factor Signaling In Mitophagic Regulation Of Myofibroblast Differentiation (2015)
  • Author(s): Kenji Kobayashi, Jun Araya, Hiromichi Hara, Shunsuke Minagawa, Nahoko Sato, Masahiro Yoshida, Yusuke Kurita, Saburo Ito, Naoki Takasaka, Satoko Fujii, Jun Kojima, , Kenichiro Shimizu, Takanori Numata, Makoto Kawaishi, Yumi Kaneko, Toshiaki Morikawa, Katsutoshi Nakayama, and Kazuyoshi Kuwano,
  • Organizer: American Thoracic Society 2015 International Conference
  • Place of Presentation: Ｄｅｎｖｅｒ，ＵＳＡ
  • Year and Date: 2015-05-15
  • Int'l Joint Research
• [Presentation] Lamin B1 In COPD Pathogenesis (2015)
  • Author(s): Saburo Ito, Jun Araya, Masahiro Yoshida, Nahoko Sato, Yusuke Kurita, Kenji Kobayashi, Naoki Takasaka, Shunsuke Minagawa, Hiromichi Hara, Shunsuke Inaki, Tsukasa Kadota, Hiroshi Wakui, Satoko Fujii, Jun Kojima, Kenichiro Shimizu, Takanori Numata, Makoto Kawaishi, Yumi Kaneko, Katsutoshi Nakayama, and Kazuyoshi Kuwano,
  • Organizer: American Thoracic Society 2015 International Conference, May 15-20, 2015 - Denver
  • Place of Presentation: Ｄｅｎｖｅｒ，ＵＳＡ
  • Year and Date: 2015-05-15
  • Int'l Joint Research
• [Presentation] Metformin Suppresses Myofibroblast Differentiation By Inhibition Of NOX4-Mediated SMAD Signaling (2015)
  • Author(s): Nahoko Sato, Naoki Takasaka, Masahiro Yoshida, Shunsuke Minagawa, Jun Araya, Nayuta Saito, Kazuya Tsubouchi, Yusuke Kurita, Kenji Kobayashi, Hiromichi Hara, Jun Kojima, Takanori Numata, Yumi Kaneko, Katsutoshi Nakayama, Toshiaki Morikawa, and Kazuyoshi Kuwano
  • Organizer: American Thoracic Society 2015 International Conference
  • Place of Presentation: Ｄｅｎｖｅｒ，ＵＳＡ
  • Year and Date: 2015-05-15
  • Int'l Joint Research
• [Presentation] Study On The Status Of Fatigue Among COPD, Asthma And ACOS (2015)
  • Author(s): Yumi Kaneko, Katsutoshi Nakayama, Masahiro Yoshida, Yusuke Kurita, Kenji Kobayashi, Hiroshi Wakui, Yu Yoshii, Saburo Ito, Naoki Takasaka, Shunsuke Minagwa, Kenichiro Shimizu, Takanori Numata, Hiromichi Hara, Makoto Kawaishi, Jun Araya, Nobuyuki Kobayashi, Kazuhiro Kondo, Kazuyoshi Kuwano
  • Organizer: American Thoracic Society 2015 International Conference
  • Place of Presentation: Ｄｅｎｖｅｒ，ＵＳＡ
  • Year and Date: 2015-05-15
  • Int'l Joint Research
• [Presentation] Clinical Importance Of Measuring Prostaglandin E- Major Urinary Metabolite (PGE-MUM) In Fibrotic Lung Diseases (FLDs) (2015)
  • Author(s): Hiromichi Hara, Tsugumi Horikiri, Jun Araya, Naoko Sato, Masahiro Yoshida, Yusuke Kurita, Kenji Kobayashi, Saburo Ito, Naoki Takasaka, Tsukasa Kadota, Yutaka Yoshii, Hiroshi Wakui, Shunsuke Minagawa, Jun Kojima, Kenichiro Shimizu, Takanori Numata, Makoto Kawaishi, Yumi Kaneko, Katsutoshi Nakayama, Kazuyoshi Kuwano,
  • Organizer: American Thoracic Society 2015 International Conference
  • Place of Presentation: Ｄｅｎｖｅｒ，ＵＳＡ
  • Year and Date: 2015-05-15
  • Int'l Joint Research
• [Book] Annual Review呼吸器2016. III. 診断の進歩 1. IGRAの臨床的重要性. (2016)
  • Author(s): 金子 有吾, 中山 勝敏, 桑野 和善.
  • Total Pages: 238
  • Publisher: 中外医学社