Mechanism of microRNA expression regulation and utility of microRNA as a biomarker in renal disease

• Project/Area Number: 15K09240
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Kidney internal medicine
• Research Institution: Yamagata University
• Principal Investigator: Konta Tsuneo 山形大学, 医学部, 教授 (60333952)
• Co-Investigator(Renkei-kenkyūsha): KAMEI Keita 山形大学, 内科学第一講座 (60756526)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: microRNA / urine / 腎障害

Outline of Final Research Achievements

In a cohort study, it was revealed that renal dysfunction, hyperuricemia and leakage of albumin in urine are independent risk factors for all-cause and cardiovascular mortalities in the participants of general health check in Japan. In a study of patients with renal diseases, a variety of microRNAs are expressed in the glomerular, renal tubular, and interstitial cells, and their expression profiles vary depending on the types of renal diseases. In longitudinal study of IgA nephropathy, the expression levels of specific types of microRNAs in urine sample correlate with the one-year decline of renal function. Based on these findings, it was shown that renal disorder and urine biomarkers are useful as indicators of all-cause and cardiovascular mortalities in general population, and renal prognosis in the patients with renal diseases.

Research Products

• [Journal Article] The Association between Glomerular Filtration Rate Estimated Using Different Equations and Mortality in the Japanese Community-Based Population: The Yamagata (Takahata) Study (2018)
  • Author(s): Kabasawa Asami、Konta Tsuneo、Suzuki Natsuko、Kamei Keita、Watanabe Sayumi、Araumi Akira、Matsuki Eri、Kon Soichiro、Oyama Midori、Ichikawa Kazunobu、Ishizawa Kenichi、Ueno Yoshiyuki、Yamashita Hidetoshi、Kayama Takamasa、Kubota Isao
  • Journal Title: Dis Marker Volume: 2018 Pages: 1-7
  • DOI: 10.1155/2018/9191832
  • Peer Reviewed / Open Access
• [Journal Article] Serum uric acid levels and mortality in the Japanese population: the Yamagata (Takahata) study (2016)
  • Author(s): Kamei K, Konta T, Ichikawa K, Sato H, Suzuki N, Kabasawa A, Suzuki K, Hirayama A, Shibata Y, Watanabe T, Kato T, Ueno Y, Kayama T, Kubota I.
  • Journal Title: Clinical Experimental Nephrology Volume: 20 Issue: 6 Pages: 904-909
  • DOI: 10.1007/s10157-016-1228-1
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Serum uric acid levels and mortality in the Japanese population: the Yamagata (Takahata) study. (2016)
  • Author(s): Kamei K, Konta T, Ichikawa K, Sato H, Suzuki N, Kabasawa A, Suzuki K, Hirayama A, Shibata Y, Watanabe T, Kato T, Ueno Y, Kayama T, Kubota I.
  • Journal Title: Clin Exp Nephrol Volume: Jan 16
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Comparison of the predictive ability of albuminuria and dipstick proteinuria for mortality in the Japanese population: the Yamagata (Takahata) study. (2015)
  • Author(s): Sato H, Konta T, Ichikawa K, Suzuki N, Kabasawa A, Suzuki K, Hirayama A, Shibata Y, Watanabe T, Kato T, Ueno Y, Kayama T, Kubota I.
  • Journal Title: Clin Exp Nephrol. Volume: 該当なし Issue: 4 Pages: 611-7
  • DOI: 10.1007/s10157-015-1193-0
  • Peer Reviewed / Open Access
• [Journal Article] Comparison of the predictive ability of albuminuria and dipstick proteinuria for mortality in the Japanese population: the Yamagata (Takahata) study. (2015)
  • Author(s): Sato H, Konta T, Ichikawa K, Suzuki N, Kabasawa A, Suzuki K, Hirayama A, Shibata Y, Watanabe T, Kato T, Ueno Y, Kayama T, Kubota I.
  • Journal Title: Clin Exp Nephrol Volume: Nov 5
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] The Association between Renal Parameters and Urinary MicroRNAs in Patients with IgA Nephropathy. (2017)
  • Author(s): Soichiro Kon, Keita Kamei, Kazunobu Ichikawa, Tsuneo Konta, Isao Kubota.
  • Organizer: 54th ERA-EDTA meeting
  • Int'l Joint Research