| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
In a cohort study, it was revealed that renal dysfunction, hyperuricemia and leakage of albumin in urine are independent risk factors for all-cause and cardiovascular mortalities in the participants of general health check in Japan. In a study of patients with renal diseases, a variety of microRNAs are expressed in the glomerular, renal tubular, and interstitial cells, and their expression profiles vary depending on the types of renal diseases. In longitudinal study of IgA nephropathy, the expression levels of specific types of microRNAs in urine sample correlate with the one-year decline of renal function. Based on these findings, it was shown that renal disorder and urine biomarkers are useful as indicators of all-cause and cardiovascular mortalities in general population, and renal prognosis in the patients with renal diseases.
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