Analysis of Downstream Pathway of BMP family affecting to Nephrotic Syndrome
Project/Area Number |
15K09245
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Kidney internal medicine
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Research Institution | The University of Tokyo |
Principal Investigator |
NOIRI Eisei 東京大学, 医学部附属病院, 特任研究員 (00301820)
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Research Collaborator |
TOKUNAGA Katsushi
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Project Period (FY) |
2015-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
|
Keywords | ヘパラン硫酸プロテオグリカン / スルファターゼ / ネフローゼ症候群 / グリピカン / Wnt / 糸球体上皮細胞 / タンパク尿 / ヘパラン硫酸 / 部分ゲノム解析 / floxed mice / ターゲットリシークエンス / inhibitor of DNA binding |
Outline of Final Research Achievements |
We have recently reported causative nephrotic proteinuric association of rs16946160 in severe phenotype. It was further proven in diabetic kidney disease in massive proteinuric phenotype. Likewise, the SULF2 was further suggested as the haplotype between SULF-PREX1 as susceptible to nephrotic proteinuria. But this region was defective to tag SNP information and LD structure for fine analysis. The current study conducted re-sequencing of this region using Ion Proton and determined LD structure. Then we concluded that there is no higher disease susceptible variant superior to this haplotype. We used mice nephrotic model previously established in BDF1 strain and found that deletion of SULF2 could induce glomerular epithelial injury to nephrotic proteinuria of which downstream was involved in BMP6 through Wnt/beta catenin pathway. This study also meticulously investigated PLA2R1 and HLA in membranous nephropathy, a representative phenotype of adult nephrotic syndrome.
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Report
(4 results)
Research Products
(12 results)
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[Journal Article] Seasonality of acute kidney injury incidence and mortality among hospitalized patients.2018
Author(s)
Iwagami M, Moriya H, Doi K, Yasunaga H, Isshiki R, Sato I, Mochida Y, Ishioka K, Ohtake T, Hidaka S, Noiri E, Kobayashi S
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Journal Title
Nephrol Dial Transplant
Volume: 2
Issue: 8
Pages: 11-11
DOI
Related Report
Peer Reviewed
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[Journal Article] High-density Association Mapping and Interaction Analysis of PLA2R1 and HLA Regions with Idiopathic Membranous Nephropathy in Japanese.2016
Author(s)
Thiri M, Honda K, Kashiwase K, Mabuchi A, Suzuki H, Watanabe K, Nakayama M, Watanabe T, Doi K, Tokunaga K, Noiri E.
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Journal Title
Sci Rep
Volume: 6
Issue: 1
Pages: 38189-38189
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Glypican-5 Increases Susceptibility to Nephrotic Damage in Diabetic Kidney.2015
Author(s)
Okamoto K, Honda K, Doi K, Ishizu T, Katagiri D, Wada T, Tomita K, Ohtake T, Kaneko T, Kobayashi S, Nangaku M, Tokunaga K, Noiri E
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Journal Title
Am J Pathol
Volume: 185
Issue: 7
Pages: 1989-1998
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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