| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
|
|---|
| Outline of Final Research Achievements |
We have recently reported causative nephrotic proteinuric association of rs16946160 in severe phenotype. It was further proven in diabetic kidney disease in massive proteinuric phenotype. Likewise, the SULF2 was further suggested as the haplotype between SULF-PREX1 as susceptible to nephrotic proteinuria. But this region was defective to tag SNP information and LD structure for fine analysis. The current study conducted re-sequencing of this region using Ion Proton and determined LD structure. Then we concluded that there is no higher disease susceptible variant superior to this haplotype. We used mice nephrotic model previously established in BDF1 strain and found that deletion of SULF2 could induce glomerular epithelial injury to nephrotic proteinuria of which downstream was involved in BMP6 through Wnt/beta catenin pathway. This study also meticulously investigated PLA2R1 and HLA in membranous nephropathy, a representative phenotype of adult nephrotic syndrome.
|
