Mechanisms of maintenance of podocyte cytoskeletal structure against metabolic stress associated with diabetes and Development of novel therapeutic strategies
Project/Area Number |
15K09247
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Kidney internal medicine
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Research Institution | Tokai University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
川上 貴久 東京大学, 医学部附属病院, 助教 (10722093)
稲城 玲子 東京大学, 医学部附属病院, 特任准教授 (50232509)
南学 正臣 東京大学, 医学部附属病院, 教授 (90311620)
田中 哲洋 東京大学, 医学部附属病院, 講師 (90508079)
加藤 秀樹 東京大学, 医学部附属病院, 講師 (90625237)
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Project Period (FY) |
2015-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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Keywords | 糸球体足細胞 / 蛋白尿 / 細胞骨格 / 高グルコース / TGF-β1 / 翻訳後修飾 / 糖尿病性腎症 |
Outline of Final Research Achievements |
We have carried out this project to determine the mechanisms of cytoskeletal derangement associated with metabolic stresses in podocytes leading to development and increase of proteinuria. In this project, we observed the changes in cytoskeletal architecture and migration of podocytes in response to several metabolic stress associated with diabetes. Interestingly, we found that altered expression of several cell cycle regulators were associated with those cellular changes. Moreover, our experimental data suggest that vitamin D might have a protective role against diabetic metabolic stresses through these pathways. We hope that novel therapeutic strategies against diabetic kidney disease will be developed by advance in this research project.
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Report
(4 results)
Research Products
(58 results)
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[Journal Article] Mitochondrial Abnormality Facilitates Cyst Formation in Autosomal Dominant Polycystic Kidney Disease2017
Author(s)
Ishimoto Y, Inagi R, Yoshihara D, Kugita M, Nagao S, Shimizu A, Takeda N, Wake M, Honda K, Zhou J, Nangaku M
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Journal Title
Mol Cell Biol
Volume: e-Pub
Issue: 24
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Upregulation of α3β1-Integrin in Podocytes in Early-Stage Diabetic Nephropathy.2016
Author(s)
Sawada K, Toyoda M, Kaneyama N, Shiraiwa S, Moriya H, Miyatake H, Tanaka E, Yamamoto N, Miyauchi M, Kimura M, Wada T, Fukagawa M.
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Journal Title
J Diabetes Res
Volume: 2016
Pages: 9265074-9265074
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Glypican-5 Increases Susceptibility to Nephrotic Damage in Diabetic Kidney.2015
Author(s)
Okamoto K, Honda K, Doi K, Ishizu T, Katagiri D, Wada T, Tomita K, Ohtake T, Kaneko T, Kobayashi S, Nangaku M, Tokunaga K, Noiri E
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Journal Title
Am J Pathol
Volume: 185
Issue: 7
Pages: 1989-1998
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Quantitating intracellular oxygen tension in vivo by phosphorescence lifetime measurement2015
Author(s)
Hirakawa Y, Yoshihara T, Kamiya M, Mimura I, Fujikura D, Masuda T, Kikuchi R, Takahashi I, Urano Y, Tobita S, Nangaku M.
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Journal Title
Sci Rep
Volume: 5
Issue: 1
Pages: 17838-17838
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] ATF6 knockout mice revealed that ER stress links lipotoxicity and kidney fibrosis.2017
Author(s)
Jao TM, Wu CH, Sugahara M, Saito H, Ishimoto Y, Okada A, Maekawa H, Aoe M, Tanaka T, Nangaku M, Inagi R
Organizer
Kidney Week 2017
Related Report
Int'l Joint Research
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[Presentation] 電解質・酸塩基平衡2016
Author(s)
和田健彦
Organizer
第59回日本腎臓学会学術総会
Place of Presentation
パシフィコ横浜(神奈川県横浜市)
Year and Date
2016-06-17
Related Report
Invited
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[Presentation] ネフローゼ症候群の治療2016
Author(s)
和田健彦
Organizer
第59回日本腎臓学会学術総会
Place of Presentation
パシフィコ横浜(神奈川県横浜市)
Year and Date
2016-06-17
Related Report
Invited
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