| Project/Area Number |
15K09249
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Niigata University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
KAZAMA Junichiro 福島県立医科大学, 医学部, 教授 (10345499)
NARITA Ichiei 新潟大学, 医歯学系, 教授 (20272817)
MARUYAMA Toru 熊本大学, 薬学部, 教授 (90423657)
KOTANI Kazuhiko 自治医科大学, 医学部, 教授 (60335510)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | インドキシル硫酸 / マクロファージ / HDL / 吸着 / インフラマソーム / MAPK / NF-ｋB / 活性炭 / 尿毒症物質 / 慢性腎臓病 / 動脈硬化 / 直接血液灌流 / 血液透析 / HDLコレステロール / コレステロールイーフラックス |
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| Outline of Final Research Achievements |
Chronic kidney disease (CKD), especially those undergoing dialysis treatment, have high risk of cardiovascular disease. We focused on function of high- density lipoprotein (HDL）and protein-bound uremic toxins (PBUTs), and found the role of PBUTs on functional abnormalities of HDL to macrophage. Further, we investigated the adsorption treatment for PBUTs with direct hemoperfusion. Thus, we have found the role of PBUTs for HDL and macrophage function and suggested a novel therapeutic strategies for removal of PBUTs for the prevention of cardiovascular disease in CKD patients.
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