Progressive kidney disease and inflammation

• Project/Area Number: 15K09251
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Kidney internal medicine
• Research Institution: Kanazawa University
• Principal Investigator: Iwata Yasunori 金沢大学, 附属病院, 特任助教 (90432137)
• Co-Investigator(Kenkyū-buntansha): 和田 隆志 金沢大学, 医学系, 教授 (40334784)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 腎臓内科学 / 感染症学 / 腎臓病学 / 免疫学 / 病原体関連分子パターン / MRSA / 進行性腎障害 / 慢性炎症

Outline of Final Research Achievements

Chronic inflammation contributes to the progression of kidney disease. We found the novel macrophage regulator molecule, which is involved in progressive kidney injury in mice model. Moreover, Apoptosis inhibitor of macrophage (AIM), which is secreted by macrophage, was detected in various kinds of human kidney disease in kidney biopsy specimen. The deposition of AIM was associated with the increase of proteinuria and the decline of eGFR. These results showed the important role of macrophage in progressive kidney disease both in mouse and human.

Research Products

• [Journal Article] Involvement of p38MAPK in Impaired Neutrophil Bactericidal Activity of Hemodialysis Patients (2018)
  • Author(s): Kamikawa Yasutaka、Sakai Norihiko、Miyake Taito、Sagara Akihiro、Shinozaki Yasuyuki、Kitajima Shinji、Toyama Tadashi、Hara Akinori、Iwata Yasunori、Shimizu Miho、Furuichi Kengo、Imamura Ryu、Suda Takashi、Kaneko Shuichi、Wada Takashi
  • Journal Title: Ther Apher Dial Volume: - Issue: 4 Pages: 345-354
  • DOI: 10.1111/1744-9987.12651
  • NAID: 120006498382
  • Peer Reviewed / Open Access
• [Journal Article] Impairment of the carnitine/organic cation transporter 1-ergothioneine axis is mediated by intestinal transporter dysfunction in chronic kidney disease. (2018)
  • Author(s): Shinozaki Y, Furuichi K, Toyama T, Kitajima S, Hara A, Iwata Y, Sakai N, Shimizu M, Kaneko S, Isozumi N, Nagamori S, Kanai Y, Sugiura T, Kato Y, Wada T.
  • Journal Title: Kidney Int. Volume: ９２ Pages: 1356-1369
  • Peer Reviewed / Open Access
• [Journal Article] Clinical and pathological significance of autoantibodies to erythropoietin receptor in type 2 diabetic patients with chronic kidney disease (2017)
  • Author(s): Hara A, Furuichi K, Koshino A, Yasuda H, Tran T, Iwata Y, Sakai N, Shimizu M, Kaneko S, Nakamura H, Wada T.
  • Journal Title: Kidney Int Rep Volume: 3 Issue: 1 Pages: 133-141
  • DOI: 10.1016/j.ekir.2017.08.017
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Inhibition of CTGF ameliorates peritoneal fibrosis through suppression of fibroblast and myofibroblast accumulation and angiogenesis (2017)
  • Author(s): Sakai Norihiko、Nakamura Miki、Lipson Kenneth E.、Miyake Taito、Kamikawa Yasutaka、Sagara Akihiro、Shinozaki Yasuyuki、Kitajima Shinji、Toyama Tadashi、Hara Akinori、Iwata Yasunori、Shimizu Miho、Furuichi Kengo、Kaneko Shuichi、Tager Andrew M.、Wada Takashi
  • Journal Title: Scientific Reports Volume: 7 Issue: 1 Pages: 5392-5392
  • DOI: 10.1038/s41598-017-05624-2
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Peripheral Blood Plasmacytosis in Severe Fever with Thrombocytopenia Syndrome (2017)
  • Author(s): Wada T, Iwata Y, Kamikawa Y, Wada T, Yachie A.
  • Journal Title: Japanese Journal of Infectious Diseases Volume: 70 Issue: 4 Pages: 470-471
  • DOI: 10.7883/yoken.JJID.2016.575
  • NAID: 130005851926
  • ISSN: 1344-6304, 1884-2836
  • Peer Reviewed / Open Access
• [Journal Article] FNDC4 acts as an anti-inflammatory factor on macrophages and improves colitis in mice. (2016)
  • Author(s): Bosma M, Gerling M, Pasto J, Georgiadi A, Graham E, Shilkova O, Iwata Y, Almer S, Soderman J, Toftgard R, Wermeling F, Bostrom EA, Bostrom PA.
  • Journal Title: Nat Commun. Volume: 12 Issue: 1 Pages: 11314-11314
  • DOI: 10.1038/ncomms11314
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Effect of Autoantibodies to Erythropoietin Receptor in Systemic Lupus Erythematosus with Biopsy-proven Lupus Nephritis. (2016)
  • Author(s): Hara A, Furuichi K, Yamahana J, Yasuda H, Iwata Y, Sakai N, Shimizu M, Kaneko S, Wada T.
  • Journal Title: J Rheumatol. Volume: 43 Issue: 7 Pages: 1328-34
  • DOI: 10.3899/jrheum.151430
  • Peer Reviewed
• [Journal Article] Clostridium difficileのITS-PCR typeと病原性に関する検討 (2016)
  • Author(s): 竹森優喜子、千田靖子、棟居知子、堀田宏、長原三輝夫、岩田恭宜、和田泰三、坂井佳夫、和田隆志
  • Journal Title: 臨床病理 Volume: 64 Pages: 258-64
  • NAID: 40020812336
  • Peer Reviewed
• [Journal Article] Risk factors associated with relapse or infectious complications in Japanese patients with microscopic polyangiitis (2016)
  • Author(s): Kitagawa K, Furuichi K, Sagara A, Shinozaki Y, Kitajima S, Toyama T, Hara A, Iwata Y, Sakai N, Shimizu M, Kaneko S, Wada T; Kanazawa Study Group for Renal Diseases and Hypertension.
  • Journal Title: Clin Exp Nephrol Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Association of apoptosis inhibitor of macrophage (AIM) expression with urinary protein and kidney dysfunction. (2016)
  • Author(s): Oshima M, Iwata Y, Furuichi K, Sakai N, Shimizu M, Hara A, Kitajima S, Toyama T, Shinozaki Y, Sagara A, Umeda E, Kaneko S, Arai S, Miyazaki T, Wada T.
  • Journal Title: Clin Exp Nephrol Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Impact of kidney function and urinary protein excretion on intima-media thickness in Japanese patients with type 2 diabetes. (2015)
  • Author(s): Nakade Y, Toyama T, Furuichi K, Kitajima S, Miyajima Y, Fukamachi M, Sagara A, Shinozaki Y, Hara A, Shimizu M, Iwata Y, Oe H, Nagahara M, Horita H, Sakai Y, Kaneko S, Wada T.
  • Journal Title: Clin Exp Nephrol. Volume: 19 Issue: 5 Pages: 909-917
  • DOI: 10.1007/s10157-015-1088-0
  • Peer Reviewed / Open Access
• [Journal Article] Relationship between Serum Uric Acid Levels and Chronic Kidney Disease in a Japanese Cohort with Normal or Mildly Reduced Kidney Function. (2015)
  • Author(s): Toyama T, Furuichi K, Shimizu M, Hara A, Iwata Y, Sakai N, Perkovic V, Kobayashi M, Mano T, Kaneko S, Wada T.
  • Journal Title: PLoS One. Volume: 10 Issue: 9 Pages: e0137449-e0137449
  • DOI: 10.1371/journal.pone.0137449
  • NAID: 120005680030
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Messenger RNA expression profile of sleep-related genes in peripheral blood cells in patients with chronic kidney disease. (2015)
  • Author(s): Kitajima S, Iwata Y, Furuichi K, Sagara A, Shinozaki Y, Toyama T, Sakai N, Shimizu M, Sakurai T, Kaneko S, Wada T.
  • Journal Title: Clin Exp Nephrol Volume: 20 Issue: 2 Pages: 218-25
  • DOI: 10.1007/s10157-015-1150-y
  • Peer Reviewed / Open Access
• [Journal Article] Association of PAX2 and Other Gene Mutations with the Clinical Manifestations of Renal Coloboma Syndrome. (2015)
  • Author(s): Okumura T, Furuichi K, Higashide T, Sakurai M, Hashimoto S, Shinozaki Y, Hara A, Iwata Y, Sakai N, Sugiyama K, Kaneko S, Wada T.
  • Journal Title: PLoS One Volume: 10 Issue: 11 Pages: e0142843-e0142843
  • DOI: 10.1371/journal.pone.0142843
  • Peer Reviewed / Open Access
• [Presentation] The association of mRNA expression of cell wall biosynthesis related genes and the reversion to daptomycin (DAP) susceptibility in DAP non-susceptible methicillin-resistant Staphylococcus aureus (2017)
  • Author(s): Yasunori Iwata
  • Organizer: ID week 2017
• [Presentation] ダプトマイシン非感受性メチシリン耐性黄色ブドウ球菌の網羅的遺伝子解析 (2017)
  • Author(s): 岩田恭宜、千田靖子、坂井優喜子、北島信治、藤田信一、和田泰三
  • Organizer: 日本感染症学会総会
• [Presentation] Genetic factors of Methicillin-resistant Staphylococcus aureus (MRSA) has an impact on the development of AKI (2016)
  • Author(s): Yasunori Iwata, Kenji Satou, Atsushi Hase, Kengo Furuichi, Yasuko Senda, Yukiko Takemori, Taizo Wada, Shinichi Fujita, Norihiko Sakai, Shinji Kitajima, Tadashi Toyama, Yasuyuki Shinozaki, Akihiro Sagara, Taro Miyagawa, Shuichi Kaneko and Takashi Wada
  • Organizer: kidney week 2016
  • Place of Presentation: Chicago
  • Year and Date: 2016-11-15
  • Int'l Joint Research
• [Presentation] Apoptosis inhibitor of macrophage (AIM) expression in the kidney was associated with increased proteinuria and decline in renal function (2016)
  • Author(s): Yasunori Iwata, Megumi Oshima, Kengo Furuichi, Norihiko Sakai, Miho Shimizu, Akinori Hara, Shinji Kitajima, Tadashi Toyama, Yasuyuki Shinozaki, Akihiro Sagara, Eri Umeda, Shuichi Kaneko, Satoko Arai, Toru Miyazaki and Takashi Wada
  • Organizer: kidney week 2016
  • Place of Presentation: Chicago
  • Year and Date: 2016-11-15
  • Int'l Joint Research
• [Presentation] 細菌ゲノム解析からみる進行性腎疾患と全身 (2016)
  • Author(s): 岩田恭宜、和田隆志
  • Organizer: 第59回日本腎臓学会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2016-05-17
  • Invited
• [Presentation] 難治性嚢胞感染症により死亡した多発性嚢胞腎の一例 (2016)
  • Author(s): 岩田恭宜、大島恵、北島信治、竹森優喜子、千田靖子、和田泰三
  • Organizer: 第90回日本感染症学会総会
  • Place of Presentation: 仙台国際センター
  • Year and Date: 2016-04-15
• [Presentation] Clinicopathological feature of a patient with IgD-lambda type multiple myeloma showing kidney involvement (2015)
  • Author(s): Kaori Yamagichi, Taichiro Minami, Toshiya Okumura，Yasunori Iwata, Kengo Furuichi, Takashi Wada
  • Organizer: Kidney week 2015
  • Place of Presentation: San Diego, CA
  • Year and Date: 2015-11-06
  • Int'l Joint Research
• [Presentation] Erythropietin Protects Endothelial Cell from High Glucose Induced Injury (2015)
  • Author(s): Yasunori Iwata, Takashi Wada
  • Organizer: 12th World Congress on Inflammation
  • Place of Presentation: Boston, MA
  • Year and Date: 2015-08-11
  • Int'l Joint Research
• [Presentation] 若年発症ANCA関連血管炎の3例 (2015)
  • Author(s): 堀越慶輔、湯浅貴博、迫恵輔、牧石祥平、宮川太郎、相良明宏、篠崎康之、北島信治、原章規、岩田恭宜、坂井宣彦、清水美保、古市賢吾、和田隆志
  • Organizer: 第59回日本リウマチ学会総会
  • Place of Presentation: 名古屋国際会議場(愛知県名古屋市)
  • Year and Date: 2015-04-23
• [Presentation] メチシリン耐性黄色ブドウ球菌の遺伝子配列が臨床病態に与える影響 (2015)
  • Author(s): 岩田恭宜、千田靖子、竹森優喜子、和田泰三、藤田信一、北島信治
  • Organizer: 第89回日本感染症学会
  • Place of Presentation: 国立京都国際会館(京都府京都市)
  • Year and Date: 2015-04-17
• [Book] 腎疾患患者の妊娠診療ガイドライン (2017)
  • Author(s): 岩田恭宜
  • Total Pages: 4
  • Publisher: 診断と治療社
• [Book] マクロファージのすべて (2016)
  • Author(s): 岩田恭宜、和田隆志
  • Total Pages: 6
  • Publisher: 医歯薬出版社
• [Book] ヒトマイクロバイオーム研究最前線 (2016)
  • Author(s): 岩田恭宜、和田隆志
  • Total Pages: 4
  • Publisher: S&T出版
• [Book] 日常臨床のための検査値のみかた (2015)
  • Author(s): 岩田恭宜、和田隆志
  • Total Pages: 442
  • Publisher: 中外医学社
• [Book] 臨床検査のガイドライン ２０１５ (2015)
  • Author(s): 岩田恭宜、和田隆志
  • Total Pages: 446
  • Publisher: 宇宙堂八木書店