| Project/Area Number |
15K09253
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
Yasuda Hideo 浜松医科大学, 医学部附属病院, 講師 (60432209)
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| Co-Investigator(Kenkyū-buntansha) |
辻 孝之 浜松医科大学, 医学部, 助教 (30464126)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 好中球細胞外トラップ / 敗血症 / 急性腎障害 |
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| Outline of Final Research Achievements |
The purpose of this study is to clarify dynamics and roles of neutrophil extracellular traps (NETs) in septic acute kidney injury (AKI). NETs were detected in ascites but not kidney during sepsis. Neutrophils and the mitochondrial DNA as the surrogate markers ofNETs increased in ascites after the peritonitis and increased by TLR9 knockout. NETs formation in ascites was controlled by TLR9. It could improve septic AKI to control NETs in ascites.
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Report
(4 results)
Research Products
(9 results)
