NETs in septic AKI

• Project/Area Number: 15K09253
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Kidney internal medicine
• Research Institution: Hamamatsu University School of Medicine
• Principal Investigator: Yasuda Hideo 浜松医科大学, 医学部附属病院, 講師 (60432209)
• Co-Investigator(Kenkyū-buntansha): 辻 孝之 浜松医科大学, 医学部, 助教 (30464126)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 好中球細胞外トラップ / 敗血症 / 急性腎障害

Outline of Final Research Achievements

The purpose of this study is to clarify dynamics and roles of neutrophil extracellular traps (NETs) in septic acute kidney injury (AKI). NETs were detected in ascites but not kidney during sepsis. Neutrophils and the mitochondrial DNA as the surrogate markers ofNETs increased in ascites after the peritonitis and increased by TLR9 knockout. NETs formation in ascites was controlled by TLR9. It could improve septic AKI to control NETs in ascites.

Research Products

• [Journal Article] AKI次世代バイマーカーの可能性 (2018)
  • Author(s): 安田日出夫
  • Journal Title: 日本透析医学会雑誌 Volume: 51(2) Pages: 129-134
• [Journal Article] Increased nocturnal blood pressure variability is associated with renal arteriolar hyalinosis in normotensive patients with IgA nephropathy. (2017)
  • Author(s): Isobe S, Ohashi N, Ishigaki S, Tsuji N, Tsuji T, Kato A, Yasuda H.
  • Journal Title: Hypertens Res. Volume: 40(11) Issue: 11 Pages: 921-926
  • DOI: 10.1038/hr.2017.66
  • Peer Reviewed
• [Journal Article] Cytoresistance after acute kidney injury is limited to the recovery period of proximal tubule integrity and possibly involves Hippo-YAP signaling (2017)
  • Author(s): Iwakura T, Fujigaki Y*, Fujikura T, Tsuji T, Ohashi N, Kato A, Yasuda H.
  • Journal Title: Physiol Rep. Volume: 5 Issue: 11 Pages: e13310-e13310
  • DOI: 10.14814/phy2.13310
  • Peer Reviewed
• [Journal Article] Intrarenal renin-angiotensin system activity is augmented after initiation of dialysis. (2017)
  • Author(s): Ohashi N*, Isobe S, Ishigaki S, Suzuki T, Ono M, Fujikura T, Tsuji T, Kato A, Ozono S, Yasuda H.
  • Journal Title: Hypertens Res. 2017;40(4):364-370 Volume: 40(4) Issue: 4 Pages: 364-370
  • DOI: 10.1038/hr.2016.143
  • Peer Reviewed
• [Presentation] 次世代AKIバイオマーカー (2017)
  • Author(s): 安田日出夫
  • Organizer: 第62回日本透析医学会総会
  • Invited
• [Presentation] 急性腎障害早期診断マーカーの最新知見と臨床的意義 (2017)
  • Author(s): 安田日出夫
  • Organizer: 第25回医療薬学フォーラム 鹿児島 2017年7月1日
  • Invited
• [Presentation] 傍尿細管毛細血管炎を伴うMPO-ANCA関連血管炎におけるneutrophil extracellular trapsの腎臓組織内分布の検討 (2016)
  • Author(s): 辻 尚子、佐藤 太一、内藤 義隆、辻 孝之、大橋 温、加藤 明彦、安田 日出夫
  • Organizer: 第59回日本腎臓学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2016-06-18
• [Presentation] 敗血症性AKIの新たな治療票的 (2016)
  • Author(s): 安田日出夫、辻尚子、辻孝之、加藤明彦
  • Organizer: 第61回日本透析医学会学術集会・総会
  • Place of Presentation: 大阪
  • Year and Date: 2016-06-10
• [Book] 最新透析医療 先端技術との融合 (2016)
  • Author(s): 安田日出夫
  • Total Pages: 859
  • Publisher: 医薬ジャーナル