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The mechanism of anti-oxidative molecule apolipoproteinL1-mediated renoprotection

Research Project

Project/Area Number 15K09264
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Kidney internal medicine
Research InstitutionThe University of Tokushima

Principal Investigator

MURAKAMI Taichi  徳島大学, 大学院医歯薬学研究部(医学系), 助教 (30403736)

Co-Investigator(Kenkyū-buntansha) 松浦 元一  徳島大学, 病院, 特任助教 (10403734)
Co-Investigator(Renkei-kenkyūsha) KOTANI Kazuhiko  自治医科大学, 医学部, 教授 (60335510)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
KeywordsApolipoproteinL1 / HDL / 抗酸化作用 / インスリン抵抗性 / メタボリックシンドローム / 2型糖尿病 / 腎臓病 / apolipoproteinL1 / 酸化ストレス / high density lipoprotein / メタボリック症候群
Outline of Final Research Achievements

In 126 non-diabetic volunteers, multivariable linear regression analysis showed serum apoL1 positively correlated with body mass index and triglyceride, and negatively correlated with HDL cholesterol. Circulating apoL1 significantly elevates in metabolic syndrome (MS) compared with non-MS, and positively associates with HOMA-IR, thus suggesting the involvement of apoL1 in dyslipidemia in MS. Next, FPLC analysis showed the significant increase of activated apoL1 in large HDL purified from MS subjects. ApoL1/HDL cholesterol ratio is inversely associated with serum oxidative metabolites. In 36 type 2 diabetic patients, serum apoL1 significantly increases in MS, with the negative association with urine 8OHdG/Cr ratio and urine albuminuria. In 59 chronic kidney disease patients, apoL1 showed the inverse correlation with urine L-FABP. Taken together, the increased activated apoL1 on HDL may be associated with anti-oxidative activity of HDL particles, which contributes to renoprotection.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (2 results)

All 2017

All Presentation (2 results)

  • [Presentation] HDLアポ蛋白ApolipoproteinL1の血中濃度の意義についての検討2017

    • Author(s)
      村上太一
    • Organizer
      第57回日本臨床化学会年次学術会
    • Related Report
      2017 Annual Research Report
  • [Presentation] HDLアポ蛋白ApolipoproteinL1の血中濃度の意義についての検討2017

    • Author(s)
      村上太一
    • Organizer
      日本臨床検査医学会第62回中四国支部総会
    • Place of Presentation
      岡山大学医学部保健学科301講義室(岡山県、岡山市)
    • Related Report
      2016 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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