The mechanism of anti-oxidative molecule apolipoproteinL1-mediated renoprotection
| Project/Area Number |
15K09264
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | The University of Tokushima |
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Principal Investigator |
MURAKAMI Taichi 徳島大学, 大学院医歯薬学研究部(医学系), 助教 (30403736)
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| Co-Investigator(Kenkyū-buntansha) |
松浦 元一 徳島大学, 病院, 特任助教 (10403734)
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| Co-Investigator(Renkei-kenkyūsha) |
KOTANI Kazuhiko 自治医科大学, 医学部, 教授 (60335510)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | ApolipoproteinL1 / HDL / 抗酸化作用 / インスリン抵抗性 / メタボリックシンドローム / ２型糖尿病 / 腎臓病 / apolipoproteinL1 / 酸化ストレス / high density lipoprotein / メタボリック症候群 |
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| Outline of Final Research Achievements |
In 126 non-diabetic volunteers, multivariable linear regression analysis showed serum apoL1 positively correlated with body mass index and triglyceride, and negatively correlated with HDL cholesterol. Circulating apoL1 significantly elevates in metabolic syndrome (MS) compared with non-MS, and positively associates with HOMA-IR, thus suggesting the involvement of apoL1 in dyslipidemia in MS. Next, FPLC analysis showed the significant increase of activated apoL1 in large HDL purified from MS subjects. ApoL1/HDL cholesterol ratio is inversely associated with serum oxidative metabolites. In 36 type 2 diabetic patients, serum apoL1 significantly increases in MS, with the negative association with urine 8OHdG/Cr ratio and urine albuminuria. In 59 chronic kidney disease patients, apoL1 showed the inverse correlation with urine L-FABP. Taken together, the increased activated apoL1 on HDL may be associated with anti-oxidative activity of HDL particles, which contributes to renoprotection.
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Report
(4 results)
Research Products
(2 results)
