Prediction of caardiovascular disease by dyslipidemia and chronic kidney disease in a general Japanese population: The Hisayama study

• Project/Area Number: 15K09267
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Kidney internal medicine
• Research Institution: Kyushu University
• Principal Investigator: Nagata Masaharu 九州大学, 医学研究院, 共同研究員 (70645639)
• Co-Investigator(Kenkyū-buntansha): 二宮 利治 九州大学, 大学病院, 助教 (30571765) ; 清原 裕 九州大学, 医学研究院, 教授 (80161602)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2015: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: 慢性腎臓病 / 脂質異常症 / 心血管病 / 追跡研究

Outline of Final Research Achievements

The Hisayama Study is a population-based cohort study of CVD, which was established in 1961 in the town of Hisayama. A total of 2,630 community-dwelling Japanese individuals (1,107 men and 1,523 women) aged >40 years were prospectively followed up for an average of 19 years, and the association between serum non-HDL-C levels and the incidence of type-specific CVD was estimated by using a Cox proportional hazards model. At baseline, 357 subjects had CKD. During the follow-up, 186 coronary heart disease (CHD) and 277 stroke events occurred. In the CKD group, the risk of CHD was significantly higher in non-HDL-C levels of 150-189 mg/dL (hazard ratio [HR], 2.23) and in >190 mg/dL (HR, 3.20) compared to <150 mg/dL, while in the non-CKD group, the risk of CHD was significantly higher only in >190 mg/dL (HR, 2.12). Our findings suggest that the association between higher serum non-HDL-C levels and CHD was greater in individuals with CKD than those without CKD.

Research Products

• [Journal Article] Serum Non-High-Density Lipoprotein Cholesterol and Risk of Cardiovascular Disease in Community Dwellers with Chronic Kidney Disease: the Hisayama Study (2017)
  • Author(s): Usui T, Nagata M, Hata J, Mukai N, Hirakawa Y, Yoshida D, Kishimoto H, Kitazono T, Kiyohara Y, Ninomiya T
  • Journal Title: J Atheroscler Thromb Volume: 24 Issue: 7 Pages: 706-715
  • DOI: 10.5551/jat.37044
  • NAID: 130006827175
  • ISSN: 1340-3478, 1880-3873
  • Peer Reviewed / Open Access
• [Journal Article] Serum Non-High-Density Lipoprotein Cholesterol and Risk of Cardiovascular Disease in Community Dwellers with Chronic Kidney Disease: the Hisayama Study. (2016)
  • Author(s): Usui T, Nagata M, Hata J, Mukai N, Hirakawa Y, Yoshida D, Kishimoto H, Kitazono T, Kiyohara Y, Ninomiya T.
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 23
  • NAID: 130006827175
  • Peer Reviewed / Acknowledgement Compliant