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Prediction of caardiovascular disease by dyslipidemia and chronic kidney disease in a general Japanese population: The Hisayama study

Research Project

Project/Area Number 15K09267
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Kidney internal medicine
Research InstitutionKyushu University

Principal Investigator

Nagata Masaharu  九州大学, 医学研究院, 共同研究員 (70645639)

Co-Investigator(Kenkyū-buntansha) 二宮 利治  九州大学, 大学病院, 助教 (30571765)
清原 裕  九州大学, 医学研究院, 教授 (80161602)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords慢性腎臓病 / 脂質異常症 / 心血管病 / 追跡研究
Outline of Final Research Achievements

The Hisayama Study is a population-based cohort study of CVD, which was established in 1961 in the town of Hisayama. A total of 2,630 community-dwelling Japanese individuals (1,107 men and 1,523 women) aged >40 years were prospectively followed up for an average of 19 years, and the association between serum non-HDL-C levels and the incidence of type-specific CVD was estimated by using a Cox proportional hazards model. At baseline, 357 subjects had CKD. During the follow-up, 186 coronary heart disease (CHD) and 277 stroke events occurred. In the CKD group, the risk of CHD was significantly higher in non-HDL-C levels of 150-189 mg/dL (hazard ratio [HR], 2.23) and in >190 mg/dL (HR, 3.20) compared to <150 mg/dL, while in the non-CKD group, the risk of CHD was significantly higher only in >190 mg/dL (HR, 2.12). Our findings suggest that the association between higher serum non-HDL-C levels and CHD was greater in individuals with CKD than those without CKD.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report

Research Products

(2 results)

All 2017 2016

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results)

  • [Journal Article] Serum Non-High-Density Lipoprotein Cholesterol and Risk of Cardiovascular Disease in Community Dwellers with Chronic Kidney Disease: the Hisayama Study2017

    • Author(s)
      Usui T, Nagata M, Hata J, Mukai N, Hirakawa Y, Yoshida D, Kishimoto H, Kitazono T, Kiyohara Y, Ninomiya T
    • Journal Title

      J Atheroscler Thromb

      Volume: 24 Issue: 7 Pages: 706-715

    • DOI

      10.5551/jat.37044

    • NAID

      130006827175

    • ISSN
      1340-3478, 1880-3873
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Serum Non-High-Density Lipoprotein Cholesterol and Risk of Cardiovascular Disease in Community Dwellers with Chronic Kidney Disease: the Hisayama Study.2016

    • Author(s)
      Usui T, Nagata M, Hata J, Mukai N, Hirakawa Y, Yoshida D, Kishimoto H, Kitazono T, Kiyohara Y, Ninomiya T.
    • Journal Title

      Journal of Atherosclerosis and Thrombosis

      Volume: 23

    • NAID

      130006827175

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant

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Published: 2015-04-16   Modified: 2019-03-29  

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