Mechanism of phosphate-induced organ impairment
Project/Area Number |
15K09269
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Kidney internal medicine
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Research Institution | Jichi Medical University |
Principal Investigator |
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Project Period (FY) |
2015-04-01 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
|
Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | 慢性腎臓病 / ミネラル代謝異常 / 臓器障害 / 慢性炎症 / 自然免疫反応 |
Outline of Final Research Achievements |
Dietary ingestion of excess phosphorus might induce various organ damages. In this study, the phosphorus-induced kidney damage was investigated. The concentration of phosphorus is increased in renal tubule for a large amount of phosphorus excretion into the urine resulting in the maintenance of phosphorus homeostasis. Very small particles consisting of crystals might be formed by the excess of phosphorus with calcium, proteins and so on. Toll-like receptor 4 (TLR4) which is expressing on the surface of renal tubule cells might sense such particles and activate its signaling pathway resulting in cell damage, fibrosis and chronic inflammatory response. A series of these phenomena via TLR4 was suggested as a mechanism of organic disorder by excess phosphorus.
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Report
(4 results)
Research Products
(14 results)
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[Journal Article] Fibroblast growth factor 21, assisted by elevated glucose, activates paraventricular nucleus NUCB2/Nesfatin-1 neurons to produce satiety under fed states.2017
Author(s)
Santoso P, Nakata M, Shiizaki K, Boyang Z, Parmila K, Otgon-Uul Z, Hashimoto K, Satoh T, Mori M, Kuro-O M, Yada T
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Journal Title
Sci Rep
Volume: 印刷中
Issue: 1
Pages: 45819-45819
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Association between Serum Soluble Klotho Levels and Mortality in Chronic Hemodialysis Patients2015
Author(s)
Otani-Takei N, Masuda T, Akimoto T, Honma S, Watanabe Y, Shiizaki K, Miki T, Kusano E, Asano Y, Kuro-O M, Nagata D
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Journal Title
Int J Endocrinol
Volume: 2015
Pages: 406269-406269
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Presentation] Serum Fibroblast Growth Factor 21 Predicts All-Cause Mortality in End Stage Renal Disease.2016
Author(s)
1.Kohara M, Masuda T, Shiizaki K., Akimoto T, Watanabe Y, Honma S, Sekiguchi C, Miyazawa Y, Kusano E., Asano Y, Kuro-o M, Nagata D
Organizer
50th Annual Meeting of American Society of Nephrology
Place of Presentation
McCormick Place (Chicago, IL USA)
Year and Date
2016-11-15
Related Report
Int'l Joint Research
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[Presentation] リン制限はCKDステージ3で開始すべきである.2016
Author(s)
1.木村貴明, 椎崎和弘, 岩津好隆, 清水俊洋, 黒澤 明, 南木浩二, 秋山健一, 小原麻里菜, 黒尾 誠, 八木澤 隆
Organizer
第59回日本腎臓学会学術総会
Place of Presentation
パシフィコ横浜(神奈川県 横浜市)
Year and Date
2016-06-17
Related Report
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[Presentation] 析患者の血中FGF21高値は生命予後悪化の危険因子である.2016
Author(s)
3.小原麻里菜, 増田貴博, 椎崎和弘, 秋元 哲, 本間寿美子, 渡邉裕子, 齋藤 修, 武藤重明, 草野英二, 浅野 泰, 黒尾 誠, 長田太助
Organizer
第59回日本腎臓学会学術総会
Place of Presentation
パシフィコ横浜(神奈川県 横浜市)
Year and Date
2016-06-17
Related Report
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[Presentation] CKD-MBDと老化2015
Author(s)
岩津好隆、椎崎和弘、長田大助、黒尾誠
Organizer
第60回日本透析医学会学術集会・総会
Place of Presentation
横浜市
Year and Date
2015-06-26
Related Report
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