| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
In the patients with chronic kidney diseases (CKD), it is well known that vascular calcification induces various complications. In this study, we developed a mouse model to reveal the mechanisms of vascular calcification.In this model mouse, vascular smooth muscle cells in the aorta were shown to lose its phenotype and gain the characteristics of osteogenic cells in molecular level. In addition, this phenomenon was ameliorated in the mouse which lost NFkB activity (important protein for various inflammatory diseases). From these findings, it is strongly suggested that inhibitor for NFkB will be a good candidate for the prevention of vascular calcification in CKD.
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