Role of TLR/BAFF/APRIL in the pathogenesis of IgA nephropathy

• Project/Area Number: 15K09274
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Kidney internal medicine
• Research Institution: Juntendo University
• Principal Investigator: Suzuki Hitoshi 順天堂大学, 医学部, 准教授 (10468572)
• Research Collaborator: SUZUKI Yusuke ; MAKITA Yuko
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: IgA腎症 / 糖鎖異常IgA1 / 免疫複合体 / TLR / APRIL / BAFF / 糖鎖異常

Outline of Final Research Achievements

TLR9 activation induced mesangioproliferative glomerulonephritis accompanied by mesangial deposition of IgA, and C3. Serum levels of Gd-IgA, IgG-IgA immune complexes and APRIL are overproduced by TLR9 activation. Serum levels of APRIL significantly correlated with serum level of Gd-IgA and IgG-IgA immune complexes. The activation of TLR9 induced production of IL-6, and IL-6 stimulation induced overexpression of APRIL in splenocytes. In IgA nephropathy, TLR9 activation enhanced Gd-IgA1 production through overexpression of IL-6 and APRIL.

Research Products

• [Int'l Joint Research] University of Alabama at Birmingham/Columbia univeristy(米国)
• [Int'l Joint Research] University of Alabama at Birmingham/Columbia university(米国)
• [Journal Article] Serum galactose-deficient-IgA1 and IgG autoantibodies correlate in patients with IgA nephropathy (2018)
  • Author(s): Placzek W, Yanagawa H, Makita Y, Renfrow MB, Julian BA, Rizk DV, Suzuki Y, Novak J, Suzuki H
  • Journal Title: Plos One Volume: 11
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] IgA nephropathy and IgA vasculitis with nephritis have a shared feature involving galactose-deficient IgA1-oriented pathogenesis (2018)
  • Author(s): Suzuki Hitoshi、Yasutake Junichi、Makita Yuko、Tanbo Yuki、Yamasaki Kohei、Sofue Tadashi、Kano Toshiki、Suzuki Yusuke
  • Journal Title: Kidney International Volume: 93 Issue: 3 Pages: 700-705
  • DOI: 10.1016/j.kint.2017.10.019
  • Peer Reviewed / Open Access
• [Journal Article] Toll-Like Receptor 9 Stimulation Induces Aberrant Expression of a Proliferation-Inducing Ligand by Tonsillar Germinal Center B Cells in IgA Nephropathy. (2017)
  • Author(s): Muto M, Manfroi B, Suzuki H, Joh K, Nagai M, Wakai S, Righini C, Maiguma M, Izui S, Tomino Y, Huard B, Suzuki Y.
  • Journal Title: J Am Soc Nephrol Volume: 28 Issue: 4 Pages: 1227-1238
  • DOI: 10.1681/asn.2016050496
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] GWAS for serum galactose-deficient IgA1 implicates critical genes of the O-glycosylation pathway (2017)
  • Author(s): Kiryluk K, Li Y, Moldoveanu Z, Suzuki H, Reily C, Hou P, Xie J, Mladkova N, Prakash S, Fischman C, Shapiro S, LeDesma RA, Bradbury D, Ionita-Laza I, Eitner F, Rauen T, Maillard N, Berthoux F, Floege J, Chen N, Zhang H, Scolari F, Wyatt RJ, Julian BA, Gharavi AG, Novak J
  • Journal Title: PLoS Genet Volume: 13 Issue: 2 Pages: e1006609-e1006609
  • DOI: 10.1371/journal.pgen.1006609
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Prognostic Value of Serum Biomarkers of Autoimmunity for Recurrence of IgA Nephropathy after Kidney Transplantation (2017)
  • Author(s): Berthoux F, Suzuki H, Mohey H, Maillard N, Mariat C, Novak J, Julian BA
  • Journal Title: J Am Soc Nephrol Volume: 28 Issue: 6 Pages: 1943-1950
  • DOI: 10.1681/asn.2016060670
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Effect of tonsillectomy with steroid pulse therapy on circulating tumor necrosis factor receptors 1 and 2 in IgA nephropathy. (2017)
  • Author(s): Murakoshi M, Gohda T, Sonoda Y, Suzuki H, Horikoshi S, Suzuki Y
  • Journal Title: Clin Exp Nephrol Volume: 21 Issue: 6 Pages: 1068-1074
  • DOI: 10.1007/s10157-017-1408-7
  • Peer Reviewed
• [Journal Article] Inhibition of STAT3 Signaling Reduces IgA1 Autoantigen Production in IgA Nephropathy (2017)
  • Author(s): Yamada Koshi、Huang Zhi-Qiang、Raska Milan、Reily Colin、Anderson Joshua C.、Suzuki Hitoshi、Ueda Hiroyuki、Moldoveanu Zina、Kiryluk Krzysztof、Suzuki Yusuke、Wyatt Robert J.、Tomino Yasuhiko、Gharavi Ali G.、Weinmann Amy、Julian Bruce A.、Willey Christopher D.、Novak Jan
  • Journal Title: Kidney Int Rep Volume: 2 Issue: 6 Pages: 1194-1207
  • DOI: 10.1016/j.ekir.2017.07.002
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Clinical decision support system for end-stage kidney disease risk estimation in IgA nephropathy patients. (2016)
  • Author(s): Pesce F, Diciolla M, Binetti G, Naso D, Ostuni VC, Di Noia T, Vågane AM, Bjørneklett R, Suzuki H, Tomino Y, Di Sciascio E, Schena FP
  • Journal Title: Nephrol Dial Transplant Volume: 31 Issue: 1 Pages: 80-86
  • DOI: 10.1093/ndt/gfv232
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Release from Th1-type immune tolerance in spleen and enhanced production of IL-5 in Peyer's patch by cholera toxin B induce the glomerular deposition of IgA. (2016)
  • Author(s): Yamanaka T, Tamauchi H, Suzuki Y, Suzuki H, Horikoshi S, Terashima M, Iwabuchi K, Habu S, Okumura K, Tomino Y.
  • Journal Title: Immunobiol Volume: 221 Issue: 4 Pages: 577-585
  • DOI: 10.1016/j.imbio.2015.12.001
  • Peer Reviewed / Open Access
• [Journal Article] Somatic Mutations Modulate Autoantibodies against Galactose-Deficient IgA1 in IgA Nephropathy. (2016)
  • Author(s): Huang ZQ, Raska M, Stewart TJ, Reily C, King RG, Crossman DK, Crowley MR, Hargett A, Zhang Z, Suzuki H, Hall S, Wyatt RJ, Julian BA, Renfrow MB, Gharavi AG, Novak J
  • Journal Title: J Am Soc Nephrol Volume: 27 Issue: 11 Pages: 3278-3284
  • DOI: 10.1681/asn.2014101044
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Analysis of Predictive Factors for Deterioration of Renal Function in Chronic Kidney Disease Patients. (2016)
  • Author(s): Matsuzaki K*, Suzuki H*, Kobayashi T, Shimizu Y, Tomino Y
  • Journal Title: J Nephrol Ther Volume: 6 Issue: 02 Pages: 240-246
  • DOI: 10.4172/2161-0959.1000240
  • Peer Reviewed / Open Access
• [Journal Article] The effect of tolvaptan on renal excretion of electrolytes and urea nitrogen in patients undergoing coronary artery bypass surgery. (2016)
  • Author(s): Kato TS, Nakamura H, Murata M, Kuroda K, Suzuki H, Yokoyama Y, Shimada A, Matsushita S, Yamamoto T, Amano A
  • Journal Title: BMC Cardiovasc Disord Volume: 13 Issue: 1 Pages: 181-189
  • DOI: 10.1186/s12872-016-0341-0
  • Peer Reviewed
• [Journal Article] Galactose-Deficient IgA1 as a Candidate Urinary Polypeptide Marker of IgA Nephropathy? (2016)
  • Author(s): Suzuki H, Allegri L, Suzuki Y, Hall S, Moldoveanu Z, Wyatt RJ, Novak J, Julian BA
  • Journal Title: Dis Markers Volume: 2016 Pages: 1-6
  • DOI: 10.1155/2016/7806438
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Beneficial effects of tonsillectomy plus steroid pulse therapy on inflammatory and tubular markers in patients with IgA nephropathy (2016)
  • Author(s): Maruyama S, Gohda T, Suzuki Y, Suzuki H, Sonoda Y, Ichikawa S, Li Z, Murakoshi M, Horikoshi S, Tomino Y
  • Journal Title: Kidney Res Clin Pract Volume: 35 Issue: 4 Pages: 233-236
  • DOI: 10.1016/j.krcp.2016.09.002
  • Peer Reviewed / Open Access
• [Journal Article] IgA腎症における検尿の意味と新規バイオマーカー (2016)
  • Author(s): 鈴木 仁、鈴木祐介
  • Journal Title: Nephrology Frontier Volume: 15 Pages: 16-19
• [Journal Article] N-Acetylgalactosaminide α2,6-sialyltransferase II is a candidate enzyme for sialylation of galactose-deficient IgA1, the key autoantigen in IgA nephropathy. (2015)
  • Author(s): Stuchlova Horynova M, Vrablikova A, Stewart TJ, Takahashi K, Czernekova L, Yamada K, Suzuki H, Julian BA, Renfrow MB, Novak J, Raska M
  • Journal Title: Nephrol Dial Transplant Volume: 30 Issue: 2 Pages: 234-238
  • DOI: 10.1093/ndt/gfu308
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Paradigm shift in activity assessment of IgA nephropathy - optimizing the next generation of diagnostic and therapeutic maneuvers via glycan targeting. (2015)
  • Author(s): Suzuki Y, Suzuki H, Yasutake J, Tomino Y.
  • Journal Title: Expert Opin Biol Ther Volume: 15 Pages: 583-593
  • Peer Reviewed / Open Access
• [Journal Article] New Insights into the Pathogenesis of IgA Nephropathy. (2015)
  • Author(s): Novak J, Rizk D, Takahashi K, Zhang XW, Bian Q, Ueda H, Ueda Y, Reily C, Lai LY, Hao C, Novak L, Huang ZQ, Renfrow MB, Suzuki H, Julian BA.
  • Journal Title: Kidney Dis Volume: 1 Issue: 1 Pages: 8-18
  • DOI: 10.1159/000382134
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Novel lectin-independent approach to detect galactose-deficient IgA1 in IgA nephropathy. (2015)
  • Author(s): Yasutake J, Suzuki Y, Suzuki H, Hiura N, Yanagawa H, Makita Y, Kaneko E, Tomino Y
  • Journal Title: Nephrol Dial Transplant Volume: 30 Issue: 8 Pages: 1315-1321
  • DOI: 10.1093/ndt/gfv221
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] IgA腎症早期発見のための新規バイオマーカーを用いた血尿の２次スクリーニングの試み (2015)
  • Author(s): 鈴木 仁、鈴木祐介
  • Journal Title: 腎・高血圧の最新治療 Volume: 4 Pages: 28-33
• [Journal Article] 病態解明と創薬研究における有用性と限界を知る：IgA腎症 (2015)
  • Author(s): 鈴木 仁
  • Journal Title: 日本腎臓学会誌 Volume: 57 Pages: 100-103
• [Journal Article] IgA腎症の病態における糖鎖異常IgA1の意義とバイオマーカーの有用性 (2015)
  • Author(s): 鈴木 仁
  • Journal Title: 医学のあゆみ Volume: 255 Pages: 1095-1099
• [Presentation] Aberrant IgA1 O-glycosylation: common pathogenetic components of IgA nephropathy and IgA vasculitis (2018)
  • Author(s): Suzuki H, Kano T, Novak J, Suzuki Y
  • Organizer: ISN FRONTIERS meeting
  • Int'l Joint Research
• [Presentation] Molecular pathogenesis of IgA nephropathy (2018)
  • Author(s): Suzuki H
  • Organizer: 16th Asian Pacific Congress of Nephrology
  • Int'l Joint Research / Invited
• [Presentation] TLR9 activation induces overproduction of aberrantly glycosylated IgA through APRIL mediated pathway in IgA nephropathy (2017)
  • Author(s): Makita Y, Suzuki H, Kano T, Takahata A, Julian BA, Novak J, Suzuki Y
  • Organizer: 54rd ERA-EDTA
  • Int'l Joint Research
• [Presentation] Immune-complexes formation depends on apoptosis inhibitor of macrophage in IgA nephropathy (2017)
  • Author(s): Takahata A, Arai S, Kitada K, Araki K, Nogi C, Makita Y, Suzuki H, Nakata J, Horikoshi S, Miyazaki T, Suzuki Y
  • Organizer: 54rd ERA-EDTA
  • Int'l Joint Research
• [Presentation] Engineered immune complexes with galactose-deficient IgA1: A new model for IgA nephropathy (2017)
  • Author(s): Reily C, Huang ZQ, Xu N, Moldoveanu Z, Novak L, Hall S, Brown R, Lewis T, Weaver C, Weinmann A, Julian BA, Suzuki H, Willey CD, Novak J
  • Organizer: 50th Meeting of the American Society of Nephrology
  • Int'l Joint Research
• [Presentation] Dysregulation of mucosal immune response in IgA nephropathy (2017)
  • Author(s): Kano T, Suzuki H, Makita Y, Nihei Y, Suzuki Y
  • Organizer: 50th Meeting of the American Society of Nephrology
  • Int'l Joint Research
• [Presentation] Galactose-deficient IgA1 monoclonal antibody specifically identifies primary IgA nephropathy and IgA vasculitis with nephritis (2017)
  • Author(s): Suzuki H, Yasutake J, Makita Y, Yamasaki K, Kano T, Suzuki Y
  • Organizer: 50th Meeting of the American Society of Nephrology
  • Int'l Joint Research
• [Presentation] TLR9 induces overproduction of aberrantly glycosylated IgA through APRIL mediated pathway in IgA nephropathy (2017)
  • Author(s): Makita Y, Suzuki H, Nihei Y, Julian BA, Novak J, Suzuki Y
  • Organizer: 50th Meeting of the American Society of Nephrology
  • Int'l Joint Research
• [Presentation] Antibody-based targeting of APRIL as a therapeutic strategy in the treatment of IgA nephropathy; a case study in grouped ddY mouse model (2017)
  • Author(s): Myette J, Adari H, Deotale K, Shriver Z, Suzuki H, Suzuki Y
  • Organizer: 50th Meeting of the American Society of Nephrology
  • Int'l Joint Research
• [Presentation] 糖鎖異常IgA1：IgA腎症と紫斑病性腎炎における共通因子 (2017)
  • Author(s): 鈴木 仁、牧田侑子、狩野俊樹、Novak Jan、鈴木祐介
  • Organizer: 第60回日本腎臓学会学術総会
• [Presentation] TLR9活性化による糖鎖異常IgAおよび免疫複合体形成機序の解明 (2017)
  • Author(s): 牧田侑子、鈴木 仁、狩野俊樹、高畑暁子、Julian Bruce、Novak Jan、鈴木祐介
  • Organizer: 第60回日本腎臓学会学術総会
• [Presentation] 教育講演：IgA腎症の病態解明とバイオマーカーの開発 (2017)
  • Author(s): 鈴木 仁
  • Organizer: 第60回日本腎臓学会総会
  • Invited
• [Presentation] Clinical Scientist Award受賞講演：Multi-Hit Pathogenetic Pathways in IgA Nephropathy (2017)
  • Author(s): 鈴木 仁
  • Organizer: 第60回日本腎臓学会総会
  • Invited
• [Presentation] Galactose-deficient IgA1 monoclonal antibody specifically discriminate IgA nephropathy and Henoch-Schönlein purpura nephritis (2016)
  • Author(s): Hitoshi Suzuki, Junichi Yasutake, Yuko Makita, Yuki Tanbo, Kohei Yamasaki, Toshiki Kano, Yusuke Suzuki
  • Organizer: The ASN (American Society of Nephrology) 49th Annual Meeting
  • Place of Presentation: Chicago
  • Year and Date: 2016-11-18
  • Int'l Joint Research
• [Presentation] Production of aberrantly-glycosylated IgA1 and the corresponding autoantibodies is elevated in patients with Henoch- Schönlein purpura nephritis (2016)
  • Author(s): Hitoshi Suzuki, Zina Moldoveanu, Bruce A. Julian, Robert J. Wyatt, Jan Novak
  • Organizer: The ASN (American Society of Nephrology) 49th Annual Meeting
  • Place of Presentation: Chicago
  • Year and Date: 2016-11-18
  • Int'l Joint Research
• [Presentation] TLR9 activation induced overproduction of aberrantly glycosylated IgA via activation of BAFF in patients with IgA nephropathy (2016)
  • Author(s): Yuko Makita, Hitoshi Suzuki, Toshiki Kano, Akiko Takahata, Bruce A. Julian, Jan Novak, Yusuke Suzuki
  • Organizer: The ASN (American Society of Nephrology) 49th Annual Meeting
  • Place of Presentation: Chicago
  • Year and Date: 2016-11-18
  • Int'l Joint Research
• [Presentation] GWAS for serum galactose-deficient IgA1 implicates critical genes of the O-glycosylation pathway (2016)
  • Author(s): Kiryluk K, Li Y, Moldoveanu Z, Suzuki H, Hou P, Reily C, Xie J, Mladkova N, LeDesma RA, Bradbury D, Eitner F, Rauen T, Berthoux F, Floege J, Chen N, Zhang H, Scolari F, Wyatt RJ, Julian BA, Novak J, and Gharavi AG
  • Organizer: The ASN (American Society of Nephrology) 49th Annual Meeting
  • Place of Presentation: Chicago
  • Year and Date: 2016-11-18
  • Int'l Joint Research
• [Presentation] Serum Levels of IgG Autoantibodies in Patients with IgA Nephropathy Correlate with Serum Levels of the Autoantigen, Galactose-deficient IgA1 (2016)
  • Author(s): William J. Placzek, Hiroyuki Yanagawa, Yuko Makita, Matthew B. Renfrow, Bruce A. Julian, Dana V. Rizk, Yusuke Suzuki, Jan Novak, Hitoshi Suzuki
  • Organizer: The ASN (American Society of Nephrology) 49th Annual Meeting
  • Place of Presentation: Chicago
  • Year and Date: 2016-11-18
  • Int'l Joint Research
• [Presentation] 炎症と腎 (2016)
  • Author(s): 鈴木 仁
  • Organizer: 第59回日本腎臓学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2016-06-19
  • Invited
• [Presentation] IgA腎症における腎糸球体糖鎖異常IgA1の検証 (2016)
  • Author(s): 鈴木 仁、安武純一、反保由紀、牧田 侑子、鈴木 祐介
  • Organizer: 第59回日本腎臓学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2016-06-18
• [Presentation] IgA腎症の寛解が予後に与える影響 ～後方視的多施設コホート研究における検証～ (2016)
  • Author(s): 松崎慶一、鈴木祐介、鈴木仁、川村哲也、堀越哲、富野康日己、安田宜成、安田隆、松尾清一
  • Organizer: 第59回日本腎臓学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2016-06-18
• [Presentation] IgA腎症患者における血清可溶性TNF受容体と腎機能の関連性 (2016)
  • Author(s): 村越真紀、合田朋仁、苑田祐二、市川沙紀、鈴木仁、鈴木祐介
  • Organizer: 第59回日本腎臓学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2016-06-18
• [Presentation] Glomerular galactose-deficient IgA1 is specific for IgA nephropathy (2016)
  • Author(s): Hitoshi Suzuki, Yuko Makita, Miyuki Takagi, Toshiki Kano, Chieko Nogi, Akiko Takahata, Yusuke Suzuki
  • Organizer: 53rd ERA-EDTA
  • Place of Presentation: VIENNA
  • Year and Date: 2016-05-21
  • Int'l Joint Research
• [Presentation] Clinical significance of new remission criteria of IgA nephropathy for renal prognosis (2016)
  • Author(s): Keiichi Matsuzaki, Yusuke Suzuki, Hithoshi Suzuki, Satoshi Horikoshi, Yasuhiko Tomino, Testuya Kawamura, Yoshinari Yasuda, Takashi Yasuda, Seiichi Matsuo
  • Organizer: 53rd ERA-EDTA
  • Place of Presentation: VIENNA
  • Year and Date: 2016-05-21
  • Int'l Joint Research
• [Presentation] AIM regulates glomerular IgA deposition and its phlogogenisity in IgA nephropathy (2016)
  • Author(s): Takahata A, Kitada K, Nogi C, Arai S, Makita Y, Suzuki H, Nakata J, Horikoshi S, Miyazaki T, Suzuki Y
  • Organizer: 53rd ERA-EDTA
  • Place of Presentation: VIENNA
  • Year and Date: 2016-05-21
  • Int'l Joint Research
• [Presentation] Biomarkers for IgA nephropathy (2015)
  • Author(s): Suzuki H
  • Organizer: Annual Congress of Chinese Society of Nephrology
  • Place of Presentation: Zhuhai, China
  • Year and Date: 2015-11-18
  • Int'l Joint Research / Invited
• [Presentation] Novel monoclonal antibody KM55 specifically detected glomerular galactose-deficient IgA1 in patients with IgA nephropathy. (2015)
  • Author(s): Suzuki H, Yasutake J, Tanbo Y, Suzuki Y
  • Organizer: 48th American Society of Nephrology Annual Meeting
  • Place of Presentation: San-Diego, USA
  • Year and Date: 2015-11-10
  • Int'l Joint Research
• [Presentation] TLR9 activation aggravates murine IgA nephropathy; possible role of BAFF mediated pathway (2015)
  • Author(s): Makita Y, Suzuki H, Takahata A, Kano T, Horikoshi S, Suzuki Y
  • Organizer: 48th American Society of Nephrology Annual Meeting
  • Place of Presentation: San-Diego, USA
  • Year and Date: 2015-11-10
  • Int'l Joint Research
• [Presentation] 「病態解明と創薬研究における有用性と限界を知る－」IgA腎症 (2015)
  • Author(s): 鈴木 仁
  • Organizer: 第37回腎臓セミナーNEXUS
  • Place of Presentation: 東京
  • Year and Date: 2015-08-28
  • Invited
• [Presentation] 血尿二次スクリーニングにおけるIgA腎症バイオマーカーの有用性 (2015)
  • Author(s): 鈴木仁、牧田侑子、高畑暁子、福田顕弘、藤元昭一、富野康日己、鈴木祐介
  • Organizer: 第58回日本腎臓学会
  • Place of Presentation: 名古屋
  • Year and Date: 2015-06-06
• [Presentation] Aberrant APRIL expression in tonsillar germinal center B cells in IgA nephropathy patients (2015)
  • Author(s): Muto M, Suzuki Y, Bertrand H, Joh K, Suzuki H, Izui S, Tomino Y
  • Organizer: 52th congress of European Renal Ascociation-European Dyalysis and Transplantation Association
  • Place of Presentation: London
  • Year and Date: 2015-05-28
  • Int'l Joint Research
• [Presentation] 紫斑病性腎炎における糖鎖異常IgA1の病的意義 (2015)
  • Author(s): 狩野俊樹、鈴木 仁、鈴木祐介、Jan Novak、富野康日己
  • Organizer: 第112回日本内科学会総会
  • Place of Presentation: 京都
  • Year and Date: 2015-04-11
• [Book] Bio Clinica：IgA腎症研究の最前線～基礎から臨床応用へ～ (2017)
  • Author(s): 鈴木 仁
  • Publisher: 北隆館
• [Book] 腎と透析：バイオマーカーを用いた診断、活動性予測 (2017)
  • Author(s): 鈴木 仁、鈴木祐介
  • Publisher: 東京医学社
• [Patent(Industrial Property Rights)] 腎炎の鑑別方法 (2016)
  • Inventor(s): 鈴木 仁
  • Industrial Property Rights Holder: 鈴木 仁
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2016-004054
  • Filing Date: 2016-01-13