Cross-talk between the kidneys and the lungs

Research Project

Project/Area Number	15K09282
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Kidney internal medicine
Research Institution	Fujita Health University
Principal Investigator	Yuzawa Yukio 藤田保健衛生大学, 医学部, 教授 (00191479)
Co-Investigator(Kenkyū-buntansha)	林宏樹藤田保健衛生大学, 医学部, 講師 (10378086) 進藤有一郎名古屋大学, 医学部附属病院, 助教 (60608884) 西村邦宏国立研究開発法人国立循環器病研究センター, 研究開発基盤センター, 室長 (70397834) 小出滋久藤田保健衛生大学, 医学部, 講師 (40760913)
Project Period (FY)	2015-04-01 – 2018-03-31
Project Status	Completed (Fiscal Year 2017)
Budget Amount *help	¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000) Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000) Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords	腎臓学 / 臓器連関 / 肺腎連関 / 急性腎障害 / 肺炎 / 急性腎傷害 / AKI
Outline of Final Research Achievements	Organ crosstalk is known to occur in the presence of kidney injury, with the injury spreading to distal organs, including the heart. However, little knowledge exists on the crosstalk linking the kidneys and lungs. Thus, we aimed to clarify the kidney-lung crosstalk by conducting a prospective observational study on the onset and prognosis of acute kidney injury (AKI) in a cohort of patients hospitalized for pneumonia. A new severity score that takes AKI into account would allow for an easy and accurate estimation of the mortality risk during treatment of pneumonia, which causes more than 110,000 deaths in Japan per year, accounting for the third highest number of deaths after malignant neoplasms and heart disease. This study does not only verify the crosstalk between the kidneys and the lungs but also recommends the importance of future medical treatment based on organ crosstalk rather than being constrained to treatment for single organs.