| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
The kidney plays an important role in gluconeogenesis, and in the starvation condition, amount of renal gluconeogenesis increases as same as that in the liver. H+-ATPase has important roles in the activation of cytoplasmic enzymes, endocytosis and membrane recycling of channels and receptors by acidification of vesicles. In renal gluconeogenesis, glutamine converted to alpha-ketoglutarate with 2 molecules of ammonium in mitochondria, then alpha-ketoglutarate was used for gluconeogenesis. Proteins related to ammoniagenesis and gluconeogenesis were increased in the kidney of diabetes, and bafilomycin treatment inhibited renal gluconeogenesis and lowered plasma glucose to the control levels. The regulation of renal gluconeogenesis by H+-ATPase inhibitor could be a new therapeutic target of diabetes mellitus.
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