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Megalin in parathyroid disease

Research Project

Project/Area Number 15K09295
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Kidney internal medicine
Research InstitutionOsaka City University

Principal Investigator

INABA Masaaki  大阪市立大学, 大学院医学研究科, 教授 (00176405)

Co-Investigator(Kenkyū-buntansha) 今西 康雄  大阪市立大学, 大学院医学研究科, 准教授 (50326253)
Research Collaborator YAMAGATA Masayo  大阪大谷大学, 薬学部, 講師
KOBAYASHI Ikue  大阪市立大学, 医学研究科, 後期研究医
OHARA Masaya  大阪市立大学, 医学研究科, 大学院生
MIYAOKA Daichi  大阪市立大学, 医学研究科, 大学院生
HAYASHI Noriyuki  大阪市立大学, 医学研究科, 大学院生
MAEDA Tomomi  大阪市立大学, 医学研究科, 研究補助員
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywordsメガリン
Outline of Final Research Achievements

The megalin expression in SHPT parathyroid glands decreased compared to normal parathyroid glands.The expression was also suppressed in parathyroid adenomas pbtained from primary hyperparathyroidism.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (4 results)

All 2017 2015

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 1 results) Presentation (2 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] Effects of Teriparatide and Sequential Minodronate on Lumbar Spine Bone Mineral Density and Microarchitecture in Osteoporosis2017

    • Author(s)
      Miyaoka Daichi、Imanishi Yasuo、Ohara Masaya、Hayashi Noriyuki、Nagata Yuki、Yamada Shinsuke、Mori Katsuhito、Emoto Masanori、Inaba Masaaki
    • Journal Title

      Calcified Tissue International

      Volume: 101 Issue: 4 Pages: 396-403

    • DOI

      10.1007/s00223-017-0295-y

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association between poor glycemic control, impaired sleep quality, and increased arterial thickening in type 2 diabetic patients.2015

    • Author(s)
      Yoda K, Inaba M, Hamamoto K, Yoda M, Tsuda A, Mori K, Imanishi Y, Emoto M, Yamada S
    • Journal Title

      PLoS One

      Volume: 10 Issue: 4 Pages: e0122521-e0122521

    • DOI

      10.1371/journal.pone.0122521

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Cinacalcet accelerates amino-terminal truncation of human parathyroid hormone (1-84) in the patients with primary2017

    • Author(s)
      Yasuo Imanishi, Akira Ishii, Masaaki Inaba
    • Organizer
      The 3rd International Symposium on the Calcium-sensing Receptor
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Parathyroid Hormone Increases EphrinB2/EphB4 of Osteoclast/Osteoblast Coupling Factor in Primary Hyperparathyroidism Model2017

    • Author(s)
      Yuki Nagata, Yasuo Imanishi, Tomomi Maeda, Daichi Miyaoka, Noriyuki Hayashi, Masaaki Inaba
    • Organizer
      ASBMR 2017 Annual Meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research

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Published: 2015-04-16   Modified: 2019-03-29  

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