The role of TET2 in mineralocorticoid receptor mediated transcription through epigenetic mechanisms and development of hypertension
Project/Area Number |
15K09296
|
Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Kidney internal medicine
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Research Institution | Keio University |
Principal Investigator |
Kobayashi Sakiko 慶應義塾大学, 医学部(信濃町), 特任講師 (80383727)
|
Project Period (FY) |
2015-04-01 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
|
Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | ミネラルコルチコイド受容体 / 転写共役因子 / エピゲノム / 高血圧 / 生活習慣病 |
Outline of Final Research Achievements |
To elucidate the mechanisms of MR mediated transcription through epigenetic mechanisms, we decided to focus on one of demethylase, ten-eleven translocation 2(TET2) among MR interacting proteins which were obtained in our MR-interacting protein-screening. Knock down of TET2 suppressed the transcriptional activation of MR target genes, SGK1 and ENaC, by aldosterone and it was suggested that TET2 transactivates MR mediated transcription. Other proteins related to epigenetic mechanisms which were obtained in our screening were also shown to control MR mediated transcription.
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Report
(4 results)
Research Products
(20 results)
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[Journal Article] Radioiodine-Associated Exacerbation of Graves' Orbitopathy in the Japanese Population: Randomized Prospective Study.2015
Author(s)
Watanabe N, Noh JY, Kozaki A, Iwaku K, Sekiya K, Kosuga Y, Matsumoto M, Suzuki M, Yoshihara A, Ohye H, Kobayashi S, Kunii Y, Mukasa K, Sugino K, Inoue T, Ito K.
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Journal Title
J Clin Endocrinol Metab
Volume: 100(7)
Issue: 7
Pages: 2700-2708
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Substituting Potassium Iodide for Methimazole as the Treatment for Graves' Disease During the First Trimester May Reduce the Incidence of Congenital Anomalies: A Retrospective Study at a Single Medical Institution in Japan.2015
Author(s)
Yoshihara A, Noh JY, Watanabe N, Mukasa K, Ohye H, Suzuki M, Matsumoto M, Kunii Y, Suzuki N, Kameda T, Iwaku K, Kobayashi S, Sugino K, Ito K.
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Journal Title
Thyroid
Volume: 25(10)
Issue: 10
Pages: 1155-1161
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Presentation] Usefulness of Dexamethasone Suppression Test in the Diagnosis of Primary Aldosteronism Subtypes2018
Author(s)
M Nomura, S Kobayashi, I Kurihara, K Miyashita, K Yokota,A Murai-Takeda, T Nakamura, M Morisaki, N Kohata, Y Oshima, Y Minami, K Saitoh, H Itoh
Organizer
43rd Meeting of the International Aldosterone Conference
Related Report
Int'l Joint Research
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[Presentation] Adrenal Cysts with High Aldosterone Levels in Cystic Fluid: A Clinicopathological Study of 5 Adrenal Cyst Cases Using CYP11B2 Immunohistochemistry2018
Author(s)
N Kohata, I Kurihara, S Kobayashi, K Yokota, Y Mitsuishi, M Morisaki, Y Oshima, Y Koike, K Saitoh, K Kameyama, H Itoh
Organizer
43rd Meeting of the International Aldosterone Conference
Related Report
Int'l Joint Research
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[Presentation] Essential role of intestinal epithelial mineralocorticoid receptor in the regulation of sodium absorption and blood pressure.2016
Author(s)
143.Toshifumi Nakamura, Isao Kurihara, Sakiko Kobayashi, Kenichi Yokota, Ayano Murai-Takeda, Yuko Mitsuishi, Mitsuha Morisaki, Nao Kohata, Yosuke Oshima, Gunther Schutz, Hirotaka Shibata, Hiroshi Itoh
Organizer
The 26th Scientific Meeting of the International Society of Hypertension
Place of Presentation
韓国(ソウル)
Year and Date
2016-09-24
Related Report
Int'l Joint Research
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[Presentation] MR Sensitivity is enhanced in High Fat Diet Mice under Equally-adjusted Salt Intake.2016
Author(s)
144.Mitsuha Morisaki, Isao Kurihara, Sakiko Kobayashi, Kenichi Yokota, Ayano Murai-Takeda, Rie Jo, Yuko Mitsuishi, Toshifumi Nakamura, Nao Kohata, Yosuke Oshima, Hirotaka Shibata, Hiroshi Itoh
Organizer
The 26th Scientific Meeting of the International Society of Hypertension
Place of Presentation
韓国(ソウル)
Year and Date
2016-09-24
Related Report
Int'l Joint Research
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[Presentation] Cases of Aldosterone-producing Adenomas which were Cured by Radiofrequency Ablation: Ongoing Confirmatory Clinical Study for Efficacy and Safety.2016
Author(s)
141.Sakiko Kobayashi, Isao Kurihara, Kenichi Yokota, Ayano Murai-Takeda, Yuko Mitsuishi, Toshifumi Nakamura, Mitsuha Morisaki, Nao Kohata, Yosuke Oshima, Sota Oguro, Kazutoshi Miyashita, Hiroshi Itoh, Hirotaka Shibata, Hiroshi Itoh
Organizer
The 26th Scientific Meeting of the International Society of Hypertension
Place of Presentation
韓国(ソウル)
Year and Date
2016-09-24
Related Report
Int'l Joint Research
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[Presentation] 原発性アルドステロン症の病態と内臓脂肪量の関連性の検討2016
Author(s)
137.栗原 勲, 大山 貴子, 小林 佐紀子, 横田 健一, 武田 彩乃, 三石 木綿子, 城 理絵, 中村 俊文, 盛崎 瑞葉, 柴田 洋孝, 伊藤 裕
Organizer
第34回日本肥満症治療学会学術集会
Place of Presentation
東京コンベンションホール(東京都中央区)
Year and Date
2016-07-01
Related Report
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[Presentation] 腸管上皮ミネラルコルチコイド受容体は腸管ENaCを介したNa吸収により血圧を調節する2016
Author(s)
136.中村 俊文, 栗原 勲, 小林 佐紀子, 横田 健一, 武田 彩乃, 城 理絵, 三石 木綿子, 盛崎 瑞葉, 高畑 尚, 大嶋 洋佑, 伊藤 裕
Organizer
第53回日本臨床分子医学会学術総会
Place of Presentation
東京国際フォーラム(東京都千代田区)
Year and Date
2016-04-11
Related Report
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[Presentation] 複数の腫瘍があるPAにおける超選択的副腎静脈サンプリングの意義2015
Author(s)
大嶋 洋佑, 栗原 勲, 宮下 和季, 小林 佐紀子, 横田 健一, 城 理絵, 門松 賢, 武田 彩乃, 小黒 草太, 宮嶋 哲, 亀山 香織, 伊藤 裕
Organizer
臨床内分泌代謝update
Place of Presentation
東京国際フォーラム(東京都千代田区)
Year and Date
2015-11-27
Related Report
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[Presentation] 妊娠中のレボチロキシンナトリウムによる補充療法の妊娠転帰に与える影響2015
Author(s)
小林 佐紀子, 吉村 弘, 向笠 浩司, 國井 葉, 大江 秀美, 渡邊 奈津子, 松本 雅子, 吉原 愛, 栗原 勲, 伊藤 公一, 伊藤 裕
Organizer
日本内分泌学会
Place of Presentation
ホテルニューオータニ(東京都港区)
Year and Date
2015-04-23
Related Report
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