Development and clinical application of disease modifying drug for Alzheimer's Disease
| Project/Area Number |
15K09306
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Hirosaki University |
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Principal Investigator |
Shoji Mikio 弘前大学, 医学研究科, 教授 (60171021)
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| Co-Investigator(Renkei-kenkyūsha) |
Kawarabayashi Takeshi 弘前大学, 大学院医学研究科, 准教授 (90186156)
Nakamura Takumi 弘前大学, 医学部附属病院, 助手 (80744193)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 認知症 / Alzheimer病 / 脳アミロイド / Abeta / 認知機能 / 病理 / ELISA / Western blot / 病態修飾薬 / アミロイド / 家族性アルツハイマー病 / アルツハイマー病 |
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| Outline of Final Research Achievements |
Alzheimer's disease (AD) is the major cause of dementia. To clarify the pathogenesis and development of disease modifyed drugs (DMD) of AD, we studied effects of oral immunization of recombinant soybean consisting of Abeta epitope (Abeta+) in AD model mice TgCRND8. Induction of anti-Abeta antibodies, prevention of memory decline and Abeta plaque accumulation. Abeta oligomer was also suppressed. No adverse reactions were observed. Thus, Abuta+ is promissing DMT. In study of Hirosaki Family, we found 43 AD patients out of total 285 family members, mean onset age is 48 years of Age and duration is about 10 years.
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Report
(4 results)
Research Products
(32 results)
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[Journal Article] Neuropathology of PARK14 is identical to idiopathic Parkinson's disease2017
Author(s)
Miki Y, Yoshizawa T, Morohashi S, Seino Y, Kijima H, Shoji M, Mori A, Yamashita C, Hatano T, Hattori N, Wakabayashi K
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Journal Title
Mov Disord
Volume: -
Issue: 5
Pages: 35-35
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Presentation] Abeta oligomers in synaptic lipid rafts induce phosphorylated tau and impair signal transduction2017
Author(s)
Takeshi Kawarabayashi, Sakiko Narita, Kaoru Sato, Takumi, Nakamura, Mie Hirohata, Naoko Nakahata, and Mikio Shoji
Organizer
Neuroscience 2017, the Society for Neuroscience, 47th Annual Meeting, Washington D.C, Nov 11-15
Related Report
Int'l Joint Research
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[Presentation] DIAN-Japan HUGSM 710 site, Hirosaki, Japan,2017
Author(s)
Mikio Shoji, Naoko Nakahata, Tomoyo Shirato, Sakiko Narita, Takumi Nakamura, Seino Yusuke, Mie Hirohata, Takeshi Kawarabayashi
Organizer
2017 DIAD Family Conference, London, July 15
Related Report
Int'l Joint Research
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