The compensatory micro circulation regulation mechanism against cerebral perfusion pressure decrease

Research Project

Project/Area Number	15K09313
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Neurology
Research Institution	Mie University
Principal Investigator	yata kenichiro 三重大学, 医学系研究科, 産学官連携研究員 (40467361)
Co-Investigator(Kenkyū-buntansha)	及川伸二三重大学, 医学系研究科, 准教授 (10277006) 冨本秀和三重大学, 医学系研究科, 教授 (80324648)
Project Period (FY)	2015-04-01 – 2018-03-31
Project Status	Completed (Fiscal Year 2017)
Budget Amount *help	¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000) Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000) Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords	脳灌流圧低下 / 代償性脳循環調節機構 / 二光子レーザー顕微鏡 / 脳循環予備能 / 代償性血管拡張 / 二光子顕微鏡 / アセタゾラマイド / 慢性脳低灌流
Outline of Final Research Achievements	Cervical carotid artery bifurcation is a predilection site of the atherosclerosis, which is a major cause of cerebral infarction. There is a compensatory circulation regulation mechanism against cerebral perfusion pressure decrease. However, the detail mechanism occurring under hypoperfusion condition remains poorly understood. In this study, we performed in vivo imaging for bilateral common carotid artery occlusion mouse brain using Two-photon laser-scanning microscopy. We elucidated that vasodilatation occurred with peripheral artery under mild cerebral hypoperfusion condition. However, we admitted that vasoconstriction occurred with peripheral artery under severe cerebral hypoperfusion condition.