An investigation for optimal signal crosstalk in heparin binding growth factor promoting neurogenesis
| Project/Area Number |
15K09326
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Juntendo University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
KIMATA Koji 愛知医科大学, 大学院医学研究科, 特任教授 (10022641)
SASAKI Takako 大分大学, 大学院医学研究科, 助教 (30133193)
KEREVER Aurelien 順天堂大学, 大学院医学研究科, 助教 (70623594)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | ヘパラン硫酸プロテオグリカン / ヘパリン親和性増殖因子 / 成体神経新生 / 糖鎖 / 硫酸化 / 細胞外マトリックス / ヘパラン硫酸プロテオグリ カン / 肝細胞増殖因子(HGF) / ヘパラン硫酸プ ロテオグリカン |
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| Outline of Final Research Achievements |
Heparin affinity growth factor group is expected as one of therapeutic targets for neurodegenerative diseases typified by hepatocyte growth factor (HGF), but there are many problems to be solved to realize clinical application. In this study, we aim to develop an adult neurogenesis control method by targeting heparan sulfate proteoglycan (HSPG) in the extracellular matrix and optimizing GF activity localization and "signal crosstalk" with other heparin affinity growth factors. Modification of sugar chain was considered important for preparation of heparin affinity growth factor / heparan sulfate chain typified by FGF - 2 which controls adult neurogenesis. We proceeded with disaccharide analysis using samples of the adventitial neurogenic region, the subventricular zone and the hippocampus, and showed characteristics of sugar chain modification such as sulfation.
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Report
(4 results)
Research Products
(29 results)
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[Journal Article] Perlecan is required for the chondrogenic differentiation of synovial mesenchymal cells through regulation of Sox9 gene expression2017
Author(s)
Sadatsuki R, Kaneko H, Futami I, Kinoshita M, Nonaka R, Culley KL, Otero M, Hada S, Goldring MB, Yamada Y, Kaneko K, Arikawa-Hirasawa E, Ishijima M
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Journal Title
J Orthop Res
Volume: 35
Issue: 4
Pages: 837-46
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Quantitative Histological Validation of Diffusion Tensor MRI with Two-Photon Microscopy of Cleared Mouse Brain.2016
Author(s)
Kamagata K, Kerever A, Yokosawa S, Otake Y, Ochi H, Hori M, Kamiya K, Tsuruta K, Tagawa K, Okazawa H, Aoki S, Arikawa-Hirasawa E.
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Journal Title
Magn Reson Med Sci.
Volume: 15(4)
Pages: 416-421
Related Report
Peer Reviewed / Open Access
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[Journal Article] A missense mutation in domain III in HSPG2 in Schwartz-Jampel syndrome compromises secretion of perlecan into the extracellular space.2015
Author(s)
Iwata S, Ito M, Nakata T, Noguchi Y, Okuno T, Ohkawara B, Masuda A, Goto T, Adachi M, Osaka H, Nonaka R, Arikawa-Hirasawa E, Ohno K.
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Journal Title
Neuromuscul Disord.
Volume: 25(8)
Issue: 8
Pages: 667-71
DOI
Related Report
Peer Reviewed
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[Journal Article] See-through Brains and Diffusion Tensor MRI Clarified Fiber Connections: A Preliminary Microstructural Study in a Mouse with Callosal Agenesis2015
Author(s)
Kerever A, Kamagata K, Yokosawa S, Otake Y, Ochi H, Yamada T, Hori M, Kamiya K, Nishikori A, Aoki S, Arikawa-Hirasawa E.
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Journal Title
Magnetic Resonance in Medical Sciences
Volume: 14
Issue: 2
Pages: 159-162
DOI
NAID
ISSN
1347-3182, 1880-2206
Related Report
Peer Reviewed
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