| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
We compared the levels of plasma CoQ10 in patients with MSA with those in age-, sex-, and COQ2 genotype-matched controls and found decreased levels of plasma CoQ10 in patients with MSA regardless of the COQ2 genotype.
We found functional deficiency of mitochondrial respiration and anti-oxidative system in induced pluripotent stem cell (iPSC)-derived neurons from an MSA patient with the compound heterozygous COQ2 mutations. We also found an increase in apoptosis of iPSC-derived neurons from MSA patients.
These findings support a hypothesis that supplementation with CoQ10 is beneficial for patients with MSA.
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