The search for a biomarker for multiple system atrophy
| Project/Area Number |
15K09334
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Mitsui Jun 東京大学, 医学部附属病院, 特任准教授 (70579862)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 多系統萎縮症 / 神経変性疾患 / バイオマーカー / コエンザイムQ10 / 酸化ストレス / 電子伝達系 / iPS細胞 / コエンザイム!Q10 |
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| Outline of Final Research Achievements |
We compared the levels of plasma CoQ10 in patients with MSA with those in age-, sex-, and COQ2 genotype-matched controls and found decreased levels of plasma CoQ10 in patients with MSA regardless of the COQ2 genotype.
We found functional deficiency of mitochondrial respiration and anti-oxidative system in induced pluripotent stem cell (iPSC)-derived neurons from an MSA patient with the compound heterozygous COQ2 mutations. We also found an increase in apoptosis of iPSC-derived neurons from MSA patients.
These findings support a hypothesis that supplementation with CoQ10 is beneficial for patients with MSA.
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Report
(4 results)
Research Products
(9 results)
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[Journal Article] Three-year follow-up of high-dose ubiquinol supplementation in a case of familial multiple system atrophy with compound heterozygous COQ2 mutations.2017
Author(s)
Mitsui J, Koguchi K, Momose T, Takahashi M, Matsukawa T, Yasuda T, Tokushige S, Ishiura H, Goto J, Nakazaki S, Kondo T, Ito H, Yamamoto Y and Tsuji S.
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Journal Title
Cerebellum
Volume: -
Issue: 3
Pages: 1-9
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Variants associated with Gaucher disease in multiple system atrophy.2015
Author(s)
Mitsui J, Matsukawa T, Sasaki H, Yabe I, Nakahara Y, Momose Y, Takahashi Y, Hara K, Kakita A, Yamada M, Takahashi H, Onodera O, Nishizawa M, Watanabe H, Nakashima K, Ito H, Izumi Y, Kaji R, Kato T, Tsuji S, et al.
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Journal Title
Ann Clin Transl Neurol.
Volume: 2
Issue: 4
Pages: 417-426
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] Variants associated with Gaucher disease in multiple system atrophy.2015
Author(s)
Mitsui J, Matsukawa T, Sasaki H, Yabe I, Matsushima M, Dürr A, Brice A, Takashima H, JAMSAC, NAMSA-SG, Tsuji S.
Organizer
The 67th American Academy of Neurology Annual Meeting
Place of Presentation
Washington DC (United States of America)
Year and Date
2015-04-22
Related Report
Int'l Joint Research
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