Development of biomarkers useful for early diagnosis and treatment optimization of ATTR amyloidosis

• Project/Area Number: 15K09336
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neurology
• Research Institution: Shinshu University
• Principal Investigator: Sekijima Yoshiki 信州大学, 学術研究院医学系, 准教授 (60322715)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: アミロイドーシス / トランスサイレチン / バイオマーカー

Outline of Final Research Achievements

We developed TTR oligomer assay system using antibody which specifically bind to misfolded TTR oligomer. By using this system, we showed that patients with ATTR amyloidosis have significantly higher level of serum misfolded TTR oligomer as compared with healthy controls and asymptomatic mutation carriers. In addition, we showed that treatment with liver transplantation or TTR tetramer stabilizers significantly decrease serum TTR oligomer level. We also showed that 11C-Pittsburgh compound B (PIB)-PET can detect ATTR amyloid deposition on barin, heart, stomach, spleen, lacrimal gland, salivary glands, thyroid gland, lymph nodes, skin, and muscle. These non-invasive biomarkers will be useful for early diagnosis and treatment optimization of ATTR amyloidosis.

Research Products

• [Journal Article] Visualization of multiple organ amyloid involvement in systemic amyloidosis using (11)C-PiB PET imaging (2018)
  • Author(s): Ezawa N, Katoh N, Oguchi K, Yoshinaga T, Yazaki M, Sekijima Y
  • Journal Title: Eur J Nucl Med Mol Imaging Volume: 45 Issue: 3 Pages: 452-461
  • DOI: 10.1007/s00259-017-3814-1
  • Peer Reviewed
• [Journal Article] Diagnosis and management of transthyretin familial amyloid polyneuropathy in Japan: red-flag symptom clusters and treatment algorithm. (2018)
  • Author(s): Sekijima Y, Ueda M, Koike H, Misawa S, Ishii T, Ando Y
  • Journal Title: Orphanet J Rare Dis Volume: 13 Issue: 1 Pages: 6-6
  • DOI: 10.1186/s13023-017-0726-x
  • Peer Reviewed / Open Access
• [Journal Article] 遺伝性ATTRアミロイドーシス (2018)
  • Author(s): 関島良樹
  • Journal Title: Clinical Neuroscience Volume: 36 Pages: 198-199
  • Int'l Joint Research
• [Journal Article] ATTR型CAAの臨床的意義 (2018)
  • Author(s): 関島良樹
  • Journal Title: 神経内科 Volume: 88 Pages: 300-304
  • Int'l Joint Research
• [Journal Article] Tafamidis for the Treatment of Hereditary Transthyretin Amyloid Cardiomyopathy: A Case Report (2017)
  • Author(s): Fujita T, Inomata T, Kaida T, Iida Y, Ikeda Y, Nabeta T, Ishii S, Maekawa E, Naruke T, Koitabashi T, Kitamura E, Sekijima Y, Ako J
  • Journal Title: Cardiology Volume: 137 Issue: 2 Pages: 74-77
  • DOI: 10.1159/000455089
  • Peer Reviewed
• [Journal Article] Cardiac Amyloidosis Associated With Amyloidogenic Transthyretin V122I Variant in an Elderly Japanese Woman (2017)
  • Author(s): Yoshinaga T, Yazaki M, 他4名
  • Journal Title: Circulation Journal Volume: 81 Issue: 6 Pages: 893-894
  • DOI: 10.1253/circj.CJ-16-1202
  • NAID: 130005679610
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Open Access
• [Journal Article] Marked biochemical difference in amyloid proportion between intra- and extraocular tissues in a liver-transplanted patient with hereditary ATTR amyloidosis. (2017)
  • Author(s): Yoshinaga T, Yazaki M, Kametani F, Sekijima Y, Iesato Y, Miyahara T, Tsuchiya-Suzuki A, Sano K, Higuchi K, Ikeda SI.
  • Journal Title: Amyloid. Volume: 13 (1) Issue: 1 Pages: 1-7
  • DOI: 10.1080/13506129.2016.1276055
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Pseudo-homozygous mutation due to a primer site polymorphism in hereditary ATTR amyloidosis -A pitfall of PCR-based genetic testing- (2017)
  • Author(s): Shibata Y, Matsushima M, Yabe I, Matsuda K, Nagai A, Kano T, Yamada M, Sekijima Y, Sasaki H
  • Journal Title: Amyloid Volume: 印刷中 Issue: 1 Pages: 66-67
  • DOI: 10.1080/13506129.2017.1307821
  • NAID: 120006425604
  • Peer Reviewed
• [Journal Article] Peptide probes detect misfolded transthyretin oligomers in the plasma of hereditary amyloidosis patients (2017)
  • Author(s): Schonhoft JD, Monteiro C, Plate L, Eisele YS, Kelly JM, Boland D, Parker CG, Cravatt BF, Teruya S, Helmke S, Maurer M, Berk J, Sekijima Y, Novais M, Coelho T, Powers ET, Kelly JW
  • Journal Title: Sci Transl Med Volume: 9 Issue: 407
  • DOI: 10.1126/scitranslmed.aam7621
  • Peer Reviewed
• [Journal Article] First nationwide survey on systemic wild-type ATTR amyloidosis in Japan (2017)
  • Author(s): Sekijima Y、Yazaki M、Ueda M、Koike H、Yamada M、Ando Y
  • Journal Title: Amyloid Volume: 25 Issue: 1 Pages: 8-10
  • DOI: 10.1080/13506129.2017.1409706
  • Peer Reviewed
• [Journal Article] アミロイドニューロパチーの診断と治療の最前線 (2017)
  • Author(s): 関島良樹
  • Journal Title: Peripheral Nerve Volume: 28 Pages: 246-250
  • Int'l Joint Research
• [Journal Article] Cardiac amyloidosis associated with amyloidogenic transthyretin V122I variant in an elderly Japanese woman (2017)
  • Author(s): Yoshinaga T, Yazaki M, Ohno M, Komada S, Koyama J, Sekijima Y
  • Journal Title: Circulation Journal Volume: 印刷中
  • NAID: 130005679610
  • Peer Reviewed
• [Journal Article] Effects of tafamidis treatment on transthyretin (TTR) stabilization, efficacy, and safety in Japanese patients with familial amyloid polyneuropathy (TTR-FAP) with Val30Met and non-Varl30Met: A phase III, open-label study. (2016)
  • Author(s): Ando Y, Sekijima Y, Obayashi K, Yamashita T, Ueda M, Misumi Y, Morita H, Machii K, Ohta M, Takata A, Ikeda S.
  • Journal Title: J Neurol Sci Volume: 362 Pages: 266-271
  • DOI: 10.1016/j.jns.2016.01.046
  • Peer Reviewed / Open Access
• [Journal Article] Carpal tunnel syndrome: a common initial symptom of systemic wild-type ATTR (ATTRwt) amyloidosis. (2016)
  • Author(s): Nakagawa M, Sekijima Y, Yazaki M, Tojo K, Yoshinaga T, Doden T, Koyama J,
  • Journal Title: Ａｍｙｌｏｉｄ Volume: 23 Issue: 1 Pages: 58-63
  • DOI: 10.3109/13506129.2015.1135792
  • Peer Reviewed
• [Journal Article] Comparison of the standard and speckle tracking echocardiographic features of wild type and mutated transthyretin cardiac amyloidoses. (2016)
  • Author(s): Minamisawa M, Koyama J, Sekijima Y, Ikeda S-I, Kozuka A, Ebisawa S, Miura T, Motoki H, Okada A, Izawa A, Ikeda U.
  • Journal Title: Eur Heart J Cardiovasc Imaging Volume: 17 Issue: 4 Pages: 402-10
  • DOI: 10.1093/ehjci/jew003
  • Peer Reviewed
• [Journal Article] Cerebral amyloid angiopathy in post-transplant patients with hereditary ATTR amyloidosis (2016)
  • Author(s): Sekijima Y, Yazaki M, Oguchi K, Ezawa N, Yoshinaga T, Yamada M, Yahikozawa H, Watanabe M, Kametani F, Ikeda SI
  • Journal Title: Neurology Volume: 87 Issue: 8 Pages: 773-781
  • DOI: 10.1212/wnl.0000000000003001
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Extremely early onset hereditary ATTR amyloidosis with G47R (p.G67R) mutation (2016)
  • Author(s): Kobayashi Y, Sekijima Y, Ogawa Y, Kondo Y, Miyazaki D, Ikeda SI
  • Journal Title: Amyloid Volume: 23 Issue: 3 Pages: 205-206
  • DOI: 10.1080/13506129.2016.1185410
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] 遺伝性ATTRアミロイドーシスの診断と治療 (2016)
  • Author(s): 関島良樹
  • Journal Title: Peripheral Nerve Volume: 26 Pages: 157-160
• [Journal Article] ATTRアミロイドーシスによる心臓アミロイドーシスの治療 (2016)
  • Author(s): 関島良樹
  • Journal Title: Heart View Volume: 20 Pages: 187-193
• [Journal Article] トランスサイレチン型家族性アミロイドポリニューロパチーにおける薬物療法の機序と治療効果 (2016)
  • Author(s): 関島良樹
  • Journal Title: 神経内科 Volume: 84 Pages: 150-155
• [Journal Article] 心アミロイドーシスの診断と治療の最近の進歩 (2016)
  • Author(s): 関島良樹
  • Journal Title: 心血管薬物治療 Volume: 4 Pages: 43-47
• [Journal Article] アミロイドーシスの診断と治療の進歩 (2016)
  • Author(s): 関島良樹，加藤修明
  • Journal Title: 病理と臨床 Volume: 34 Pages: 466-471
• [Journal Article] 家族性アミロイドポリニューロパチーの新規薬物治療 (2016)
  • Author(s): 関島良樹
  • Journal Title: 自律神経 Volume: 53 Pages: 145-148
• [Journal Article] 遺伝性ATTRアミロイドーシスの新規治療指針 (2016)
  • Author(s): 関島良樹
  • Journal Title: 医学のあゆみ Volume: 258 Pages: 671-676
• [Journal Article] Cerebral amyloid angiopathy in post-transplant patients with hereditary ATTR amyloidosis (2016)
  • Author(s): Sekijima Y, Yazaki M, Oguchi K, Ezawa N, Yoshinaga T, Yamada M, Yahikozawa H, Watanabe M, Kametani F, Ikeda SI.
  • Journal Title: Neurology Volume: in press
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] The pathological and biochemical identification of possible seed-lesions of transmitted transthyretin amyloidosis after domino liver transplantaion. (2015)
  • Author(s): Yoshinaga, T, Yazaki M, Sekijima Y, Kametani F, Miyashita K, Hachiya N, Tanaka T, Koaudo N, Higuchi K, Ikeda S.
  • Journal Title: J Path: Clin Res 2015 Volume: 1 Issue: 2 Pages: 1-8
  • DOI: 10.1002/cjp2.36
  • Peer Reviewed / Open Access
• [Journal Article] Transthyretin (ATTR) amyloidosis: clinical spectrum, molecular pathogenesis and disease-modifying treatments (2015)
  • Author(s): Sekijima Y
  • Journal Title: J Neurol Neurosurg Psychiatry Volume: 86 Issue: 9 Pages: 1036-1043
  • DOI: 10.1136/jnnp-2014-308724
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] a serious complication in post-transplant patients with familial amyloid polyneuropathy (2015)
  • Author(s): Sekijima Y
  • Journal Title: J Neurol Neurosurg Psychiatry Volume: 86 Issue: 2 Pages: 124-124
  • DOI: 10.1136/jnnp-2014-308576
  • Peer Reviewed
• [Journal Article] Safety and efficacy of long-term diflunisal administration in hereditary transthyretin (ATTR) amyloidosis (2015)
  • Author(s): Sekijima Y, Tojo K, Morita H, Koyama J, Ikeda SI
  • Journal Title: Amyloid Volume: 22 Issue: 2 Pages: 79-83
  • DOI: 10.3109/13506129.2014.997872
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Left ventricular deformation and torsion assessed by speckle-tracking echocardiography in patients with mutated transthyretin-associated cardiac amyloidosis and the effect of diflunisal on myocardial function (2015)
  • Author(s): Koyama J, Minamisawa M, Sekijima Y, Ikeda SI, Kozuka A, Ebisawa S, Miura T, Motoki H, Okada A, Izawa A, Ikeda U.
  • Journal Title: IJC Heart & Vasculature Volume: 9 Pages: 1-10
  • Peer Reviewed / Open Access
• [Journal Article] Pathological, biochemical, and biophysical characteristics of the transthyretin variant Y114H (p.Y134H) explain its very mild clinical phenotype (2015)
  • Author(s): Sekijima Y, Campos RI, Hammarstrom P, Nilsson KP, Yoshinaga T, Nagamatsu K, Yazaki M, Kametani F, Ikeda SI.
  • Journal Title: Peripher Nerv Syst Volume: 20 Issue: 4 Pages: 372-379
  • DOI: 10.1111/jns.12143
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Regression of localized ureter amyloidosis after treatment with steroids suggested by Tc-99 m pyrophosphate scintigraphy (2015)
  • Author(s): Ikeda J, Katoh N, Sekijima Y, Ikeda S
  • Journal Title: Amyloid Volume: 22 Issue: 4 Pages: 257-258
  • DOI: 10.3109/13506129.2015.1089860
• [Journal Article] The first pure form of Ostertag-type amyloidosis in Japan: a sporadic case of hereditary fibrinogen Aα-chain amyloidosis associated with a novel frameshift variant (2015)
  • Author(s): Yazaki M, Yoshinaga T, Sekijima Y, Nishio S, Kanizawa Y, Kametani F, Miyashita K, Hachiya N, Higuchi K, Ikeda SI.
  • Journal Title: Amyloid Volume: 22 Issue: 2 Pages: 142-144
  • DOI: 10.3109/13506129.2015.1037389
  • Peer Reviewed / Open Access
• [Presentation] Japanese consensus of treatments for hereditary ATTR amyloidosis (2018)
  • Author(s): Sekijima Y, Ueda M, Koike H, Misawa S, Ando Y
  • Organizer: The XVIth International Symposium on Amyloidosis
  • Int'l Joint Research / Invited
• [Presentation] Tools to define the earliest diagnosis (2018)
  • Author(s): Sekijima Y
  • Organizer: The XVIth International Symposium on Amyloidosis
  • Int'l Joint Research / Invited
• [Presentation] First nationwide survey on systemic wild-type ATTR amyloidosis in Japan (2018)
  • Author(s): Sekijima Y, Yazaki M, Ueda M, Koike H, Yamada M, Ando Y
  • Organizer: The XVIth International Symposium on Amyloidosis
  • Int'l Joint Research
• [Presentation] Treatment for ATTR Amyloidosis (2017)
  • Author(s): Sekijima Y
  • Organizer: Samsung amyloidosis symposium 2017
  • Int'l Joint Research / Invited
• [Presentation] Prevalence of Transthyretin-type cerebral amyloid angiopathy in ATTR-FAP patients and its early diagnosis using PiB-PET Imaging (2017)
  • Author(s): Sekijima Y
  • Organizer: 2017 Peripheral Nerve Society Annual Meeting
  • Int'l Joint Research / Invited
• [Presentation] Current topics in Amyloidosis -from Alzheimer disease to ATTR amyloidosis- (2017)
  • Author(s): Sekijima Y
  • Organizer: XXIII World Congress of Neurology
  • Int'l Joint Research / Invited
• [Presentation] アミロイドーシス全国疫学調査における本邦の野生型ATTRアミロイドーシス診療の実態 (2017)
  • Author(s): 関島良樹，矢崎正英，植田光晴，小池春樹，山田正仁，安東由喜雄
  • Organizer: 第5回日本アミロイドーシス研究会学術集会
  • Invited
• [Presentation] 野生型ATTRアミロイドーシスの早期診断 (2017)
  • Author(s): 関島良樹
  • Organizer: 第5回日本アミロイドーシス研究会学術集会
  • Invited
• [Presentation] 遺伝性ATTRアミロイドーシスの病態に基づいた疾患修飾療法の開発 (2017)
  • Author(s): 関島良樹
  • Organizer: 第35回日本神経治療学会総会
  • Invited
• [Presentation] Transthyretin (ATTR)-type cerebral amyloid angiopathy (2017)
  • Author(s): Sekijima Y
  • Organizer: 第36回日本認知症学会学術集会
  • Invited
• [Presentation] 病態に基づいたアミロイドーシスに対する疾患修飾療法 (2016)
  • Author(s): 関島良樹
  • Organizer: 第9回日本自律神経学会総会
  • Place of Presentation: くまもと県民交流館パレア（熊本）
  • Year and Date: 2016-11-10
  • Invited
• [Presentation] アミロイドーシスを疑う、診断する (2016)
  • Author(s): 関島良樹
  • Organizer: 第4回日本アミロイドーシス研究会 学術集会
  • Place of Presentation: KKRホテル東京（東京）
  • Year and Date: 2016-08-19
  • Invited
• [Presentation] 13歳で発症した遺伝性ATTRアミロイドーシスの一例 (2016)
  • Author(s): 小林優也、小川有香、近藤恭史、宮崎大吾、関島良樹、池田修一
  • Organizer: 第4回日本アミロイドーシス研究会 学術集会
  • Place of Presentation: KKRホテル東京（東京）
  • Year and Date: 2016-08-19
• [Presentation] 遺伝性ATTRアミロイドーシスにおける11C-PIB-PETの有効性 (2016)
  • Author(s): 江澤直樹、関島良樹、矢崎正英、小口和浩、池田修一
  • Organizer: 第4回日本アミロイドーシス研究会 学術集会
  • Place of Presentation: KKRホテル東京（東京）
  • Year and Date: 2016-08-19
• [Presentation] 遺伝性ATTRアミロイドーシス長期生存例における脳アミロイドアンギオパチーの出現とその11C-PIB-PET所見の解析 (2016)
  • Author(s): 関島良樹、矢崎正英、小口和浩、江澤直樹、吉長恒明、池田修一
  • Organizer: 第4回日本アミロイドーシス研究会 学術集会
  • Place of Presentation: KKRホテル東京（東京）
  • Year and Date: 2016-08-19
• [Presentation] ドミノ移植後アミロイドーシスの臨床病理学的検討 一施設検討 (2016)
  • Author(s): 吉長恒明、矢崎正英、関島良樹、亀谷富由樹、池田修一
  • Organizer: 第4回日本アミロイドーシス研究会 学術集会
  • Place of Presentation: KKRホテル東京（東京）
  • Year and Date: 2016-08-19
• [Presentation] 肝移植後FAP患者の眼内アミロイド蛋白の laser microdissection (LMD)を用いた詳細な生化学的検討 (2016)
  • Author(s): 矢崎正英、吉長恒明、関島良樹、池田修一、宮原照良、亀谷富由樹
  • Organizer: 第4回日本アミロイドーシス研究会 学術集会
  • Place of Presentation: KKRホテル東京（東京）
  • Year and Date: 2016-08-19
• [Presentation] TTRアミロイド線維沈着部位のプロテオミクス解析 (2016)
  • Author(s): 亀谷富由樹、吉長恒明、鈴木彩子、関島良樹、矢崎正英、池田修一
  • Organizer: 第4回日本アミロイドーシス研究会 学術集会
  • Place of Presentation: KKRホテル東京（東京）
  • Year and Date: 2016-08-19
• [Presentation] Transthyretin-type cerebral amyloid angiopathy in posttransplant patients with hereditary ATTR amyloidosis: Correlates between clinical findings and PIB-PET imaging (2016)
  • Author(s): Yoshiki Sekijima
  • Organizer: The XV International Symposium on Amyloidosis
  • Place of Presentation: Uppsala Concert and Congress（Uppsala, Sweden）
  • Year and Date: 2016-07-03
  • Int'l Joint Research
• [Presentation] Diagnosis of Hereditary ATTR Amyloidosis using 11C-PIB-PET (2016)
  • Author(s): Naoki Ezawa, Yoshiki Sekijima, Masahide Yazaki, Kazuhiro Oguchi, Shu-ichi Ikeda
  • Organizer: The XV International Symposium on Amyloidosis
  • Place of Presentation: Uppsala Concert and Congress (Uppsala, Sweden）
  • Year and Date: 2016-07-03
  • Int'l Joint Research
• [Presentation] Clinicopathological characterizations of transmitted transthyretin amyloidosis after domino liver transplantation: a single-center experience (2016)
  • Author(s): Tsuneaki Yoshinaga, Masahide Yazaki, Yoshiki Sekijima, Toshihiko Ikegami, Shinichi Miyagawa, Shu-ichi Ikeda
  • Organizer: The XV International Symposium on Amyloidosis
  • Place of Presentation: Uppsala Concert and Congress (Uppsala, Sweden）
  • Year and Date: 2016-07-03
  • Int'l Joint Research
• [Presentation] Extremely Early Onset Hereditary ATTR Amyloidosis with p.G67R (G47R) Mutation (2016)
  • Author(s): Yuya Kobayashi, Yoshiki Sekijima, Yuka Ogawa, Yasuhumi Kondo, Daigo Miyazaki, Shu-ichi Ikeda,
  • Organizer: The XV International Symposium on Amyloidosis
  • Place of Presentation: Uppsala Concert and Congress (Uppsala, Sweden）
  • Year and Date: 2016-07-03
  • Int'l Joint Research
• [Presentation] Carpal Tunnel Syndrome: The Most Common Initial Symptom of Systemic Wild-type ATTR (ATTRwt) Amyloidosis (2016)
  • Author(s): Yoshiki Sekijima, Michitaka Nakagawa, Kana Tojo, Tsuneaki Yoshinaga, Masahide Yazaki, Jun koyama, Shu-ichi Ikeda
  • Organizer: The XV International Symposium on Amyloidosis
  • Place of Presentation: Uppsala Concert and Congress (UKK) in Uppsala, Sweden
  • Year and Date: 2016-07-03
  • Int'l Joint Research
• [Presentation] The first pathological and biochemical identification of seed-lesions of transmitted transthyretin amyloidosis after domino liver transplantation (2016)
  • Author(s): Tsuneaki Yoshinaga, Masahide Yazaki, Yoshiki Sekijima, Fuyuki Kametani, Naomi Hachiya, Keiichi Higuchi, Shu-ichi Ikeda
  • Organizer: The XV International Symposium on Amyloidosis
  • Place of Presentation: Uppsala Concert and Congress (UKK) in Uppsala, Sweden
  • Year and Date: 2016-07-03
  • Int'l Joint Research
• [Presentation] 家族性アミロイドーシスの治療最前線 (2016)
  • Author(s): 関島良樹
  • Organizer: 第59回日本腎臓学会学術総会
  • Place of Presentation: パシフィコ横浜（横浜）
  • Year and Date: 2016-06-17
  • Invited
• [Presentation] Cutting-edge therapies for amyloid neuropathy (2016)
  • Author(s): Yoshiki Sekijima
  • Organizer: 第57回日本神経学会学術大会
  • Place of Presentation: 神戸国際会議場 (神戸)
  • Year and Date: 2016-05-18
  • Invited
• [Presentation] de novo amyloidosis（医原性FAP）における生化学的解析とその臨床像 (2016)
  • Author(s): 吉長恒明、矢崎正英、関島良樹、亀谷富由樹、池田修一
  • Organizer: 第57回日本神経学会学術大会
  • Place of Presentation: 神戸国際会議場 (神戸)
  • Year and Date: 2016-05-18
• [Presentation] Val30Met TTR型FAP患者に対するTTR四量体安定化薬の長期的効果 (2016)
  • Author(s): 大橋信彦、小平農、関島良樹、森田洋、池田修一
  • Organizer: 第５７回日本神経学会学術大会
  • Place of Presentation: 神戸国際会議場（神戸）
  • Year and Date: 2016-05-18
• [Presentation] 11C-PIB-PETを用いた遺伝性ATTRアミロイドーシス診断の試み (2016)
  • Author(s): 江澤直樹、関島良樹、矢崎正英、小口和浩、池田修一
  • Organizer: 第57回日本神経学会学術大会
  • Place of Presentation: 神戸国際会議場（神戸）
  • Year and Date: 2016-05-18
• [Presentation] Cerebral Amyloid Angiopathy in Post-transplant Patients with Hereditary ATTR Amyloidosis (2016)
  • Author(s): Yoshiki Sekijima, Masahide Yazaki, Kazuhiro Oguchi, Tsuneaki Yoshinaga, Shu-ichi Ikeda
  • Organizer: 第57回日本神経学会学術大会
  • Place of Presentation: 神戸国際会議場（神戸）
  • Year and Date: 2016-05-18
• [Presentation] Laser microdissectionを用いたアミロイドーシス沈着病態解析への応用 (2016)
  • Author(s): 矢崎正英、吉長恒明、関島良樹、池田修一、亀谷富由樹
  • Organizer: 第57回日本神経学会学術大会
  • Place of Presentation: 神戸国際会議場（神戸)
  • Year and Date: 2016-05-18
• [Presentation] Recent progress in the treatment of hereditary ATTR amyloidosis-beginning of a new era of hereditary neurodegenerative disease therapy and genetic counseling- (2016)
  • Author(s): Yoshiki Sekijima
  • Organizer: 第13回国際人類遺伝学会
  • Place of Presentation: 国立京都国際会館 (京都)
  • Year and Date: 2016-04-03
  • Int'l Joint Research / Invited
• [Presentation] Transthyretin-type Cerebral Amyloid Angiopathy in Post-transplant Patients with Hereditary ATTR Amyloidosis: Correlates between Clinical Findings and Amyloid-PET Imaging (2016)
  • Author(s): Yoshiki Sekijima, Masahide Yazaki, Kazuhiro Oguchi, Tsuneaki Yoshinaga, Shu-Ichi Ikeda
  • Organizer: 第13回国際人類遺伝学会
  • Place of Presentation: 国立京都国際会館 (京都)
  • Year and Date: 2016-04-03
  • Int'l Joint Research
• [Presentation] 遺伝性 ATTR アミロイドーシスの治療の現状と今後の展望 (2015)
  • Author(s): 関島良樹
  • Organizer: 第33回日本神経治療学会総会
  • Place of Presentation: 名古屋国際会議場（愛知県名古屋市）
  • Year and Date: 2015-11-26
  • Invited
• [Presentation] Val30Met TTR型FAP患者の末梢神経障害に対するジフルニサルの中期的効果 (2015)
  • Author(s): 大橋信彦、関島良樹、小平農、森田洋、池田修一
  • Organizer: 第45回日本臨床神経生理学会学術大会
  • Place of Presentation: 大阪国際会議場（大阪府大阪市）
  • Year and Date: 2015-11-05
• [Presentation] アミロイドーシスの最新トピックス －アルツハイマー病からATTRアミロイドーシスまで－ (2015)
  • Author(s): 関島良樹
  • Organizer: 第48回日本神経病理学会北海道地方会
  • Place of Presentation: 北海道大学医学部（北海道札幌市）
  • Year and Date: 2015-10-31
  • Invited
• [Presentation] 家族性アミロイドポリニューロパチーの新規薬物治療 (2015)
  • Author(s): 関島良樹
  • Organizer: 第68回日本自律神経学会総会
  • Place of Presentation: ウインクあいち（愛知県名古屋市）
  • Year and Date: 2015-10-29
  • Invited
• [Presentation] アミロイドーシスと感染症 ―歴史に秘められた意外な関係― (2015)
  • Author(s): 関島良樹
  • Organizer: 第20回日本神経感染症学会総会・学術大会
  • Place of Presentation: ホテルメルパルク長野（長野県長野市）
  • Year and Date: 2015-10-22
  • Invited
• [Presentation] 家族性アミロイドポリニューロパチーの病態に基づいた疾患修飾療法の開発 (2015)
  • Author(s): 関島良樹
  • Organizer: 日本人類遺伝学会第60回大会
  • Place of Presentation: 京王プラザホテル（東京都）
  • Year and Date: 2015-10-14
  • Invited
• [Presentation] Mechanistic linkage between ATTR therapies and clinical benefit: Results from a quantitative ELISA assay demonstrates a dramatic reduction in non-native TTR levels in FAP patients treated with tafamidis (2015)
  • Author(s): Justin Chapman, Teresa Coelho, Yoshiki Sekijima, Jeffery W. Kelly, Xin Jiang
  • Organizer: 140th Annual Meeting of the American Neurological Association
  • Place of Presentation: Chicago Marriott Downtown Magnificent Mile（Chicago,USA)
  • Year and Date: 2015-09-27
  • Int'l Joint Research
• [Presentation] 家族性アミロイドポリニューロパチー (FAP) の診断と治療 (2015)
  • Author(s): 関島良樹
  • Organizer: 第26回日本末梢神経学会学術集会
  • Place of Presentation: ホテルブエナビスタ（長野県松本市）
  • Year and Date: 2015-09-18
  • Invited
• [Presentation] トランスサイレチン・アミロイドーシスの診断と治療 (2015)
  • Author(s): 関島良樹
  • Organizer: 第63回日本心臓病学会学術集会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2015-09-18
  • Invited
• [Presentation] 肝移植後22年後に脳アミロイドアンギオパチーで脳出血を起こした家族性アミロイドポリニューロパチーの1例 (2015)
  • Author(s): 大橋信彦、池田淳司、小平農、関島良樹、池田修一
  • Organizer: 第214回日本神経学会関東・甲信越地方会
  • Place of Presentation: 砂防会館（東京都）
  • Year and Date: 2015-09-05
• [Presentation] 疾患修飾療法が可能になった遺伝性ニューロパチー・心筋症の診断と治療 (2015)
  • Author(s): 関島良樹
  • Organizer: 第3回日本アミロイドーシス研究会学術集会
  • Place of Presentation: KKRホテル東京（東京都）
  • Year and Date: 2015-08-21
  • Invited
• [Presentation] Laser microdissection-LC-MS/MSを用いたプロテオーム解析によるアミロイドーシス病型診断の有効性と分子病態解析への応用 (2015)
  • Author(s): 矢崎正英、吉長恒明、関島良樹、亀谷富由樹、八谷如美、池田修一
  • Organizer: 第3回日本アミロイドーシス研究会学術集会
  • Place of Presentation: KKRホテル東京（東京都）
  • Year and Date: 2015-08-21
  • Invited
• [Presentation] 肝移植後遺伝性ATTRアミロイドーシス患者における脳アミロイドアンギオパチー (2015)
  • Author(s): 関島良樹、矢崎正英、小口和浩、吉長恒明、東城加奈、池田修一
  • Organizer: 第3回日本アミロイドーシス研究会学術集会
  • Place of Presentation: KKRホテル東京（東京都）
  • Year and Date: 2015-08-21
  • Invited
• [Presentation] 各種アミロイドタンパク質沈着組織のレーザーマイクロダイセクションおよび質量分析を用いたプロテオミクス解析 (2015)
  • Author(s): 亀谷富由樹、吉長恒明、鈴木彩子、関島良樹、矢崎正英、池田修一
  • Organizer: 第3回日本アミロイドーシス研究会学術集会
  • Place of Presentation: KKRホテル東京（東京都）
  • Year and Date: 2015-08-21
  • Invited
• [Presentation] 自験例ドミノ肝移植レシピエントにおける医原性アミロイドーシスの臨床病理学的検討 (2015)
  • Author(s): 吉長恒明、矢﨑正英、関島良樹、三田篤義、池上俊彦、宮川眞一、池田修一
  • Organizer: 第33回日本肝移植研究会
  • Place of Presentation: ホテルオークラ神戸（兵庫県神戸市）
  • Year and Date: 2015-05-28
• [Presentation] 家族性アミロイドポリニューロパチーの診断と治療選択 ―肝移植と薬剤の使い分け― (2015)
  • Author(s): 関島良樹
  • Organizer: 第56回日本神経学会学術大会
  • Place of Presentation: 朱鷺メッセ (新潟県新潟市)
  • Year and Date: 2015-05-20
  • Invited
• [Presentation] アミロイドニューロパチー診断のポイント～臨床所見と検査の実際～ (2015)
  • Author(s): 関島良樹
  • Organizer: 第56回日本神経学会学術大会
  • Place of Presentation: 朱鷺メッセ (新潟県新潟市)
  • Year and Date: 2015-05-20
  • Invited
• [Presentation] トランスサイレチン型家族性ポリニューロパチーに対するタファミジスの第三相試験成績 (2015)
  • Author(s): 関島良樹、大林光念、森田洋、池田修一、山下太郎、植田光晴、三隅洋平、町井克行、大田誠、高田亜実、安東由喜雄
  • Organizer: 第56回日本神経学会学術大会
  • Place of Presentation: 朱鷺メッセ (新潟県新潟市)
  • Year and Date: 2015-05-20
• [Presentation] ドミノ肝移植レシピエントにおけるde novo amyloidosis（医原性FAP）の検討 (2015)
  • Author(s): 矢崎正英，吉長恒明，関島良樹，池田修一，三田篤義，池上俊彦，宮川眞一
  • Organizer: 第56回日本神経学会学術大会
  • Place of Presentation: 朱鷺メッセ (新潟県新潟市)
  • Year and Date: 2015-05-20
• [Presentation] 心アミロイドーシスにおける虚血性脳血管障害の危険因子についての検討 (2015)
  • Author(s): 道傳 整、中川道隆、中村勝哉、安出卓司、東城加奈、関島良樹、池田修一
  • Organizer: 第56回日本神経学会学術大会
  • Place of Presentation: 朱鷺メッセ (新潟県新潟市)
  • Year and Date: 2015-05-20
• [Presentation] Val30Met TTR型FAP患者の末梢神経障害に対するジフルニサルの中期的効果 (2015)
  • Author(s): 大橋 信彦、関島良樹、小平農、森田洋、池田修一
  • Organizer: 第56回日本神経学会学術大会
  • Place of Presentation: 朱鷺メッセ (新潟県新潟市)
  • Year and Date: 2015-05-20
• [Presentation] 家族性アミロイドポリニューロパチー(FAP)に対する肝移植54例の治療評価 (2015)
  • Author(s): 鈴木 彩子、矢﨑正英、武井洋一、関島良樹、池田修一
  • Organizer: 第56回日本神経学会学術大会
  • Place of Presentation: 朱鷺メッセ (新潟県新潟市)
  • Year and Date: 2015-05-20
• [Book] アミロイドーシスのすべて (2017)
  • Author(s): 関島良樹
  • Total Pages: 250
  • Publisher: 医歯薬出版
• [Book] 遺伝カウンセリングマニュアル (2016)
  • Author(s): 関島良樹
  • Total Pages: 472
  • Publisher: 南江堂
• [Book] Annual Review2015 神経 (2015)
  • Author(s): 関島良樹
  • Publisher: 株式会社中外医学社