The study of anti-endothelial cell autoantibodies in patients with autoimmune encephalitis
| Project/Area Number |
15K09337
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Gifu University |
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Principal Investigator |
Inuzuka Takashi 岐阜大学, 大学院医学系研究科, 非常勤講師 (50184734)
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| Co-Investigator(Kenkyū-buntansha) |
木村 暁夫 岐阜大学, 大学院医学系研究科, 准教授 (00362161)
矢野 竹男 三重大学, 地域イノベーション学研究科, 教授 (00569197)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 抗血管内皮抗体 / 血液脳関門 / 自己免疫性脳炎 / 補体 / 補体Ｃ１ｑ / 自己免疫介在性脳炎 / 抗NMDAR脳炎 |
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| Outline of Final Research Achievements |
We identified the complement 1q (C1q) as a target antigen of the anti-endothelial cell autoantibodies in the serum samples of patients with neuromyelitis optica spectrum disorders (NMOSD) by immunoprecipitation using cultured human brain microvascular endothelial cell as the antigen source, followed by LC/MS/MS analysis. Serum anti-C1q autoantibody levels during the acute phase of NMOSD patients correlated with the CSF/serum albumin ratio, which is a marker of brood brain barrier (BBB) integrity. Then, we compared serum anti-C1q autoantibody levels between the 11 patients with NMDAR encephalitis and 15 healthy subjects. Serum anti-C1q autoantibody levels in patients with NMDAR encephalitis were significantly higher than those in healthy subject. We speculate that increased serum anti-C1q autoantibody levels are associated with BBB permeability, and contribute to pathogenic autoantibody influx into the CNS of autoimmune encephalitis.
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Report
(4 results)
Research Products
(18 results)
