Establishment of personalized medicine for NMO utilizing 11C-acetate PET
| Project/Area Number |
15K09339
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | University of Toyama (2016-2017)
Osaka University (2015) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
奥野 龍禎 大阪大学, 医学系研究科, 助教 (00464248)
甲田 亨 大阪大学, 医学部附属病院, 医員 (70626134)
南波 明子 大阪大学, 医学部附属病院, 医員 (80774504)
山下 和哉 大阪大学, 医学部附属病院, 医員 (40774518)
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| Project Period (FY) |
2015-10-21 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | PET / 酢酸 / アストロサイト / 多発性硬化症 / NMO / バイオマーカー / NMOSD / 高次脳機能障害 |
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| Outline of Final Research Achievements |
To distinguish NMO and MS is clinically important because the prophylactic treatments are different for each disease. We have been working to establish 11C-acetate PET as a novel imaging biomarker to distinguish those two diseases. Ten healthy controls, 11 MS patients, and 12 NMOSD patients were enrolled, and we found that astrocytic metabolism is activated in the brain with MS, while it is decreased in the brain with NMO. Thus, it is expected that we can utilize 11C-acetate PET as a novel imaging biomarker for the differential diagnosis of MS and NMOSD.
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Report
(4 results)
Research Products
(39 results)
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[Journal Article] Paraneoplastic Cerebellar Degeneration and Lambert-Eaton Myasthenic Syndrome Associated with Neuroendocrine Carcinoma of the Oropharynx2018
Author(s)
Takasugi J, Shimamura M, Koda T, Kishikawa T, Hanamoto A, Inohara H, Sato K,Morii E, Motomura M, Sakaguchi M, Nakatsuji Y, Mochizuki H.
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Journal Title
Internal Medicine
Volume: 57
Issue: 4
Pages: 587-590
DOI
NAID
ISSN
0918-2918, 1349-7235
Related Report
Peer Reviewed / Open Access
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[Journal Article] Polarization of M2 macrophages requires Lamtor1 that integrates cytokine and amino-acid signals2016
Author(s)
Kimura T, Nada S, Takegahara N, OkunoT, NojimaS, Kang S, Ito D, Morimoto K, Morimoto K, Hosokawa T, Hayama Y, Mitsui Y, Sakurai N, Sarashina-Kida H, Nishide M, Maeda Y, Takamatsu H, Okuzaki D, Yamada M, Okada M, Kumanogoh A.
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Journal Title
Nat Commun.
Volume: 7
Issue: 1
Pages: 13130-13130
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] LRRK1 is critical in the regulation of B-cell responses and CARMA1-dependent NF-κB activation.2016
Author(s)
Morimoto K, Baba Y, Shinohara H, Kang S, Nojima S, Kimura T, Ito D, Yoshida Y, Maeda Y, Sarashina-Kida H, Nishide M, Hosokawa T, Kato Y, Hayama Y, Kinehara Y, Okuno T, Takamatsu H, Hirano T, Shima Y, Narazaki M, Kurosaki T, Toyofuku T, Kumanogoh A.
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Journal Title
Scientific Reports
Volume: 6
Issue: 1
Pages: 25738-25738
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Efficacy of steroid pulse therapy in patients with multiple sclerosis and neuromyelitis optica2016
Author(s)
Yamasaki R, Matsushita T, Fukazawa T, Yokoyama K, Fujihara K, Ogino M, Yokota T, Miyamoto K, Niino M, Nomura K, Tomioka R, Tanaka M, Kawachi I, Ohashi T, Kaida KI, Matsui M, Nakatsuji Y, Ochi H, Fukaura H, Kanda T, Nagaishi A, Togo K, Mizusawa H, Murai H, Kira JI.
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Journal Title
Multiple Scler
Volume: 印刷中
Related Report
Peer Reviewed
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[Journal Article] Reply to comment on: Dietary Yeasts Reduce Inflammation in Central Nerve System via Microflora2015
Author(s)
Takata K, Tomita T, Okuno T, Kinoshita M, Koda T, Honorat JA, Takei M, Hagihara K, Sugimoto T, Mochizuki H, Sakoda S, Nakatsuji Y.
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Journal Title
Ann Clin Transl Neurol
Volume: 2（11）
Issue: 11
Pages: 1040-1040
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] mTOR signaling plays a crucial role in IFN-β non-responsiveness in MS patients with high serum Sema4A levels2017
Author(s)
Namba A, Okuno T, Koda T, Yamashita M, Shimizu m, Kinoshita M, Kumanogho A, Miyazaki Y, Niino M, Miyamoto K, Nakatsuji Y, Mochizuki H
Organizer
7th Joint ECTRIMS-ACTRIMS Meeting
Related Report
Int'l Joint Research
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[Presentation] Sema4A as a biomarker for the selection of treatment of MS2016
Author(s)
uji Nakatsuji, Toru Koda, Tatsusada Okuno, Yusei Miyazaki, Masaaki Niino, Toshiyuki Fukazawa, Kazushiro Takata, Akiko Namba, Kazuya Yamashita, Mikito Shimizu, Makoto Kinoshita, Saburo Sakoda, Atsushi Kumanogoh, Hideki Mochizuki
Organizer
Congress of the European Committee for Treatment and Research in Multiple Sclerosis
Place of Presentation
London, England
Year and Date
2016-09-14
Related Report
Int'l Joint Research
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