Therapy for multiple sclerosis targeting gamma-delta T cells and innate immunity based on genome-wide association studies in Japanese population
| Project/Area Number |
15K09341
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
山崎 亮 九州大学, 医学研究院, 准教授 (10467946)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 多発性硬化症 / γδT細胞 / 自然免疫 / マクロファージ |
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| Outline of Final Research Achievements |
We detected associated genetic loci with disability index of multiple sclerosis (MS) in Japanese population. We compared immunophenotype of γδT cells between Japanese patients with multiple sclerosis (MS) and healthy controls (HC) by flow cytometry. The percentages of Vδ2+ and Vδ2+Vγ9+ cells in γδ T cells were negatively correlated with the disability index. Presence of deleted type copy number variation at TRG, which had been clarified to be associated with MS susceptibility, were associated with the decreased expression of TRGJ1.
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Report
(4 results)
Research Products
(7 results)
