Therapy for multiple sclerosis targeting gamma-delta T cells and innate immunity based on genome-wide association studies in Japanese population

• Project/Area Number: 15K09341
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neurology
• Research Institution: Kyushu University
• Principal Investigator: Matsushita Takuya 九州大学, 大学病院, 講師 (00533001)
• Co-Investigator(Kenkyū-buntansha): 山崎 亮 九州大学, 医学研究院, 准教授 (10467946)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 多発性硬化症 / γδT細胞 / 自然免疫 / マクロファージ

Outline of Final Research Achievements

We detected associated genetic loci with disability index of multiple sclerosis (MS) in Japanese population. We compared immunophenotype of γδT cells between Japanese patients with multiple sclerosis (MS) and healthy controls (HC) by flow cytometry. The percentages of Vδ2+ and Vδ2+Vγ9+ cells in γδ T cells were negatively correlated with the disability index. Presence of deleted type copy number variation at TRG, which had been clarified to be associated with MS susceptibility, were associated with the decreased expression of TRGJ1.

Research Products

• [Journal Article] Association of Decreased Percentage of Vδ2+Vγ9+ γδ T Cells With Disease Severity in Multiple Sclerosis (2018)
  • Author(s): Maimaitijiang G, Shinoda K, Nakamura Y, Masaki K, Matsushita T, Isobe N, Yamasaki R, Yoshikai Y, Kira J.
  • Journal Title: Frontiers in Immunology Volume: 9 Pages: 1-10
  • DOI: 10.3389/fimmu.2018.00748
  • Peer Reviewed / Open Access
• [Presentation] Deviated Repertoire of γδ T Cells is Associated with Disease Severity of Multiple Sclerosis. (2017)
  • Author(s): Maimaitijiang Guzailiayi、Shinoda Koji、Nakamura Yuri、Matsushita Takuya、Yamasaki Ryo、Yoshikai Yasunobu、Kira Jun-ichi
  • Organizer: 10th Congress of the Pan-Asian-Committee-for-Treatment-and-Research-in-Multiple-Sclerosis (PACTRIMS)
  • Int'l Joint Research
• [Presentation] Genome-Wide Association Study (GWAS) for Clinical Phenotypes of Multiple Sclerosis in The Japanese (2015)
  • Author(s): Takuya Matsushita
  • Organizer: 8th Congress of the Pan-Asian Committee for Treatment and Research in Multiple Sclerosis
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2015-11-21
  • Int'l Joint Research
• [Presentation] A Genome-wide Association Study(GWAS) in the Japanese Population Reveals Novel Genetic Risk Factors for Multiple Sclerosis and Neuromyelitis Optica (2015)
  • Author(s): Jun-ichi Kira
  • Organizer: World Congress of Neurology 2015
  • Place of Presentation: Santiago, Chile
  • Year and Date: 2015-11-03
  • Int'l Joint Research
• [Presentation] 多発性硬化症の疾患表現型に関連する遺伝因子 (2015)
  • Author(s): 松下拓也
  • Organizer: 第27回日本神経免疫学会学術集会
  • Place of Presentation: 岐阜
  • Year and Date: 2015-09-15
• [Presentation] Genetic factors associated with disability progression and age at onset of multiple sclerosis in the Japanese (2015)
  • Author(s): Takuya Matsushita
  • Organizer: Asia Pacific of School of Neuroimmunology, 1st APSNI Course
  • Place of Presentation: 東京
  • Year and Date: 2015-08-31
  • Int'l Joint Research
• [Presentation] Genetic factors associated with clinical phenotypes of multiple sclerosis (2015)
  • Author(s): Takuya Matsushita
  • Organizer: 第56回日本神経学会学術大会
  • Place of Presentation: 新潟
  • Year and Date: 2015-05-21