Investigation on molecular mechanisms of HAM/TSP pathogenesis mediated by the interactions between HBZ and its target host factors.
| Project/Area Number |
15K09345
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Kawasaki Medical School |
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Principal Investigator |
Saito Mineki 川崎医科大学, 医学部, 教授 (40398285)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | HTLV-1 / HBZ / 慢性炎症 / 免疫老化 / 感染防御 / 自己抗体 |
|---|
| Outline of Final Research Achievements |
Among HTLV-1-infected individuals, there is an association between HTLV-1 subgroups (subgroup-A or -B) and the risk of HAM/TSP in the Japanese population. To investigate the role of HTLV-1 subgroups in viral pathogenesis, we studied the functional difference in the subgroup-specific viral transcriptional regulator HBZ by microarray analysis followed by validation using clinical samples derived from HTLV-1 infected individuals. Transcriptional changes in Jurkat Tet-On human T-cells that express each subgroup of HBZ protein under the control of an inducible promoter showed different target gene profiles. Interestingly, HBZ induced the expression of different classes of non-coding RNAs (ncRNAs), as well as genes related to inflammation and CD4 T-cell senescence. These newly identified HBZ target genes may constitute candidates for novel biomarker and therapeutic target of HAM/TSP.
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Report
(4 results)
Research Products
(25 results)
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[Presentation] Establishment of a novel small animal model for HAM/TSP.2017
Author(s)
Ushirogawa H, Arishima S, Yasunaga J, Kubota R, Ohshima K, Izumo S, Matsuoka M, Saito M.
Organizer
The 18th International Conference on Human Retrovirology: HTLV and Related Viruses.
Place of Presentation
Hotel Grand Arc Hanzomon, Tokyo, Japan.
Year and Date
2017-03-10
Related Report
Int'l Joint Research
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[Presentation] Plasma autoantibody against cancer testis antigen NY-ESO-1 in HTLV-1 infected individuals with different clinical status.2017
Author(s)
Saito M, Shiohama Y, Naito T, Matsuzaki T, Matsuura E, Tanaka R, Tomoyose T, Fukushima T, Takashima H, Tanaka Y
Organizer
The 18th International Conference on Human Retrovirology: HTLV and Related Viruses.
Place of Presentation
Hotel Grand Arc Hanzomon, Tokyo, Japan.
Year and Date
2017-03-08
Related Report
Int'l Joint Research
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