| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
Among HTLV-1-infected individuals, there is an association between HTLV-1 subgroups (subgroup-A or -B) and the risk of HAM/TSP in the Japanese population. To investigate the role of HTLV-1 subgroups in viral pathogenesis, we studied the functional difference in the subgroup-specific viral transcriptional regulator HBZ by microarray analysis followed by validation using clinical samples derived from HTLV-1 infected individuals. Transcriptional changes in Jurkat Tet-On human T-cells that express each subgroup of HBZ protein under the control of an inducible promoter showed different target gene profiles. Interestingly, HBZ induced the expression of different classes of non-coding RNAs (ncRNAs), as well as genes related to inflammation and CD4 T-cell senescence. These newly identified HBZ target genes may constitute candidates for novel biomarker and therapeutic target of HAM/TSP.
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