The inhibitory change using double stimulation somatosensory evoked response in aging and Parkinsonian effects

• Project/Area Number: 15K09350
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neurology
• Research Institution: Nagoya University
• Principal Investigator: Masaaki Hirayama 名古屋大学, 医学系研究科(保健), 准教授 (30283435)
• Co-Investigator(Kenkyū-buntansha): 中村 友彦 名古屋大学, 医学部附属病院, 助教 (00437039) ; 渡辺 宏久 名古屋大学, 脳とこころの研究センター, 特任教授 (10378177) ; 寳珠山 稔 名古屋大学, 脳とこころの研究センター, 教授 (30270482)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 脳磁図 / 反回抑制 / 感覚誘発磁界 / パーキンソン病 / 加齢変化 / 体性感覚磁界 / 痛み / 体性感覚誘発磁場 / 誘発脳磁図 / 感覚認知

Outline of Final Research Achievements

Somatosensory evoked cerebral magnetic field (SEF) was measured in elderly healthy subjects and PD, and the recurrent curve was measured. Measurement of 80 ms repetitive suppression at one second intervals between healthy elderly and PD and young group was measured. The current was estimated by continuous stimulation twice with a constant current of 0.2 ms. There was a significant difference in the first and second wave between the young and the elderly. In PD and elderly people, the response of the first wave and second wave was different in suppression pattern between elderly group and PD. the recovery function by aging change was less suppression of the first wave in the elder group. On the other hand, recovery of the second wave was facilitated in the senior group. The first and second components are different in recovery function and change by aging. In patients with PD, it was suggested that the disorder of suppression mechanism associated with aging was dissociated.

Research Products

• [Journal Article] Association between changes in visual evoked magnetic fields and non-motor features in Parkinson’s disease (2017)
  • Author(s): Y. Fujisawa, T. Minato, J.I. Uemura, M. Hoshiyama, H. Watanabe, M. Hirayama
  • Journal Title: Nagoya Journal of Medical Science Volume: 79 Issue: 2 Pages: 147-155
  • DOI: 10.18999/nagjms.79.2.147
  • NAID: 120006220102
  • ISSN: 2186-3326
  • URL: https://nagoya.repo.nii.ac.jp/records/24332
  • Peer Reviewed
• [Journal Article] Molecular hydrogen alleviates motor deficits and muscle degeneration in mdx mice (2017)
  • Author(s): S. Hasegawa, M. Ito, M. Fukami, M. Hashimoto, M. Hirayama, K. Ohno
  • Journal Title: Redox Rep Volume: 22 Issue: 1 Pages: 26-34
  • DOI: 10.1080/13510002.2015.1135580
  • Peer Reviewed
• [Journal Article] The efficacy of a novel drug zonisamide in the modulation of oxidative stress in Parkinson's disease (2017)
  • Author(s): M. Hirayama, T. Minato, T. Maeda, T. Nakamura, M. Katsuno
  • Journal Title: neurology and clinical neuroscience Volume: 5 Issue: 2 Pages: 49-54
  • DOI: 10.1111/ncn3.12103
  • Peer Reviewed
• [Journal Article] Progression of Parkinson's disease is associated with gut dysbiosis: Two-year follow-up study (2017)
  • Author(s): Minato Tomomi、Maeda Tetsuya、Fujisawa Yoshiro、Tsuji Hirokazu、Nomoto Koji、Ohno Kinji、Hirayama Masaaki
  • Journal Title: PLOS ONE Volume: 12 Issue: 11 Pages: e0187307-e0187307
  • DOI: 10.1371/journal.pone.0187307
  • Peer Reviewed
• [Journal Article] Lower body mass index is associated with orthostatic hypotension in Parkinson's disease (2017)
  • Author(s): T. Nakamura, M. Suzuki, M. Ueda, M. Hirayama, M. Katsuno
  • Journal Title: J. Neurol. Sci. Volume: 372 Pages: 14-18
  • DOI: 10.1016/j.jns.2016.11.027
  • NAID: 120006220239
  • Peer Reviewed
• [Journal Article] Cardiac parasympathetic dysfunction in the early phase of Parkinson's disease (2017)
  • Author(s): M. Suzuki, T. Nakamura, M. Hirayama, M. Ueda, M. Katsuno, G. Sobue
  • Journal Title: J. Neurol. Volume: 264 Issue: 2 Pages: 333-340
  • DOI: 10.1007/s00415-016-8348-0
  • NAID: 120006305562
  • Peer Reviewed
• [Journal Article] Erratum to: A randomized double-blind multi-center trial of hydrogen water for Parkinson's disease: protocol and baseline characteristics (2017)
  • Author(s): A. Yoritaka, T. Abe, C. Ohtsuka, T. Maeda, M. Hirayama, H. Watanabe, H. Saiki, G. Oyama, J. Fukae, Y. Shimo, T. Hatano, S. Kawajiri, Y. Okuma, Y. Machida, H. Miwa, C. Suzuki, A. Kazama, M. Tomiyama, T. Kihara, M. Hirasawa, H. Shimura, N. Hattori
  • Journal Title: BMC Neurol. Volume: 17 Issue: 1 Pages: 35-35
  • DOI: 10.1186/s12883-017-0817-2
  • Peer Reviewed
• [Journal Article] Association between changes in visual evoked magnetic fields and non-motor features in Parkinson’s disease (2017)
  • Author(s): Fujisawa Y, Minato T, Ueyama J, Hoshiyama M, Watanabe H,Hirayama M
  • Journal Title: nagoya journal Volume: 印刷中
  • NAID: 120006220102
  • Acknowledgement Compliant
• [Journal Article] Serum tyrosine-to-phenylalanine ratio is low in Parkinson's disease (2016)
  • Author(s): Hirayama, M.,Tsunoda, M.,Yamamoto, M.,Tsuda, T.,Ohno, K.
  • Journal Title: J Parkinsons Dis Volume: 6 Issue: 2 Pages: 423-31
  • DOI: 10.3233/jpd-150736
  • Peer Reviewed / Open Access
• [Journal Article] Association of leptin with orthostatic blood pressure changes in Parkinson's disease (2016)
  • Author(s): Nakamura, T.,Suzuki, M.,Okada, A.,Suzuki, J.,Hasegawa, S.,Koike, H.,Hirayama, M.,Katsuno, M.,Sobue, G.
  • Journal Title: Mov Disord Volume: 31 Issue: 9 Pages: 1417-21
  • DOI: 10.1002/mds.26678
  • Peer Reviewed / Open Access
• [Journal Article] Expanding concept of clinical conditions and symptoms in multiple system atrophy (2016)
  • Author(s): Watanabe H, Riku Y, Nakamura T, Hara K, Ito M, Hirayama M, Yoshida M, Katsuno M, Sobue G.
  • Journal Title: Rinsho Shinkeigaku Volume: 56 Issue: 7 Pages: 457-464
  • DOI: 10.5692/clinicalneurol.cn-000903
  • NAID: 130006882268
  • ISSN: 0009-918X, 1882-0654
  • Peer Reviewed / Open Access
• [Journal Article] A randomized double-blind multi-center trial of hydrogen water for Parkinson’s disease: protocol and baseline characteristics (2016)
  • Author(s): Yoritaka, A.,Abe, T.,Ohtsuka, C.,Maeda, T., Hirayama, M. et al
  • Journal Title: BMC Neurology Volume: 16 Issue: 1 Pages: 66-66
  • DOI: 10.1186/s12883-016-0589-0
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Intestinal Dysbiosis and Lowered Serum Lipopolysaccharide-Binding Protein in Parkinson's Disease (2015)
  • Author(s): Hasegawa, S. Goto, S. Tsuji, H. Okuno, T. Asahara, T. Nomoto, K. Shibata, A. Fujisawa, Y. Minato, T. Okamoto, A. Ohno, K. Hirayama, M.
  • Journal Title: PLoS One Volume: 10 Issue: 11 Pages: e0142164-e0142164
  • DOI: 10.1371/journal.pone.0142164
  • Peer Reviewed / Open Access
• [Journal Article] Beneficial biological effects and the underlying mechanisms of molecular hydrogen - comprehensive review of 321 original articles. (2015)
  • Author(s): Ichihara M, Sobue S, Ito M, Ito M, Hirayama M, Ohno K.
  • Journal Title: Med Gas Res Volume: 5 Issue: 1 Pages: 12-12
  • DOI: 10.1186/s13618-015-0035-1
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Impaired peripheral vasoconstrictor response to orthostatic stress in patients with multiple system atrophy (2015)
  • Author(s): Suzuki, J. Nakamura, T. Hirayama, M. Mizutani, Y. Okada, A. Ito, M. Watanabe, H. Sobue, G.
  • Journal Title: Parkinsonism Relat Disord Volume: 21 Issue: 8 Pages: 917-22
  • DOI: 10.1016/j.parkreldis.2015.05.023
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Characteristic laryngoscopic findings in Parkinson's disease patients after subthalamic nucleus deep brain stimulation and its correlation with voice disorder (2015)
  • Author(s): Tsuboi, T. Watanabe, H. Tanaka, Y. Ohdake, R. Yoneyama, N. Hara, K. Ito, M. Hirayama, M. Yamamoto, M. Fujimoto, Y. Kajita, Y. Wakabayashi, T. Sobue, G.
  • Journal Title: J Neural Transm (Vienna) Volume: 122 Issue: 12 Pages: 1663-72
  • DOI: 10.1007/s00702-015-1436-y
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Noninvasive monitoring of plasma L-dopa concentrations using sweat samples in Parkinson's disease (2015)
  • Author(s): Tsunoda, M. Hirayama, M. Tsuda, T. Ohno, K.
  • Journal Title: Clin Chim Acta Volume: 442 Pages: 52-5
  • DOI: 10.1016/j.cca.2014.12.032
  • Peer Reviewed / Open Access
• [Journal Article] Disinhibitory shift of recovery curve of somatosensory-evoked response in elderly: A magnetoencephalographic study (2014)
  • Author(s): Goto, S. Fujisawa, Y. Uemura, J. I. Yamada, S. Hoshiyama, M. Hirayama, M
  • Journal Title: Clin Neurophysiol Volume: 126 Issue: 6 Pages: 1228-33
  • DOI: 10.1016/j.clinph.2014.09.018
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Distinct phenotypes of speech and voice disorders in Parkinson's disease after subthalamic nucleus deep brain stimulation. (2014)
  • Author(s): Tsuboi T, Watanabe H, Tanaka Y, Ohdake R, Yoneyama N, Hara K, Nakamura R, Watanabe H, Senda J, Atsuta N, Ito M, Hirayama M, Yamamoto M, Fujimoto Y, Kajita Y, Wakabayashi T, Sobue G.
  • Journal Title: J Neurol Neurosurg Psychiatry Volume: Epub Issue: 8 Pages: 856-64
  • DOI: 10.1136/jnnp-2014-308043
  • Peer Reviewed / Open Access
• [Presentation] Microbiota and Neurodegenerative diseases (2017)
  • Author(s): Masaaki Hirayama
  • Organizer: 16th japan international Parkinson disease & movement disorders sympsium in Takamatsu
  • Place of Presentation: Takamatsu
  • Year and Date: 2017-02-17
  • Int'l Joint Research / Invited
• [Presentation] パーキンソン病(PD) 患者に対する酸化アルブミンを用いたバイオマーカー としての有用性 (2017)
  • Author(s): 瀧本圭一，湊智美，上山純，伊藤美佳子，大野欽司，平山正昭
  • Organizer: 第11回パーキンソン病・運動障害疾患コングレス
• [Presentation] Parkinson 病に対する水素水の多施設共同二重盲検並行群間試験 (2017)
  • Author(s): 頼高朝子，大塚千久美，前田哲也，平山正昭 ，阿部隆志，渡辺宏久 ，斉木英資 ，大山彦光 ，深江治郎，下泰司 ，波田野琢， 河尻澄宏 ，大熊泰之，町田裕 ，三輪英人，鈴木智香子，風間明日香 ，冨山誠彦 ，木原武士，平澤基之，志村秀樹，小田英世 ，服部信孝
  • Organizer: 第7回日本分子状水素医学生物学会大会
• [Presentation] Clinical benefits and optimal dosage of Istradefylline in Parkinsons disease (2017)
  • Author(s): Tetsuya Maeda, Kenichi Kashihara, Masaaki Hirayama
  • Organizer: 13th International Conference on Alzheimer’s and Parkinson’s Diseases
  • Int'l Joint Research
• [Presentation] Two-year prospective study reveals that gut dysbiosis predicts progression of Parkinson’s disease (2017)
  • Author(s): Tomomi Minato, Yoshiro Fujisawa, Hirokazu Tsuji, Takashi Asahara, Koji Nomoto, Akira Okamoto, Tetsuya Maeda, Kinji Ohno, Masaaki Hirayama
  • Organizer: 21th International Congress of Parkinson’s disease and Movement Disorders
  • Int'l Joint Research
• [Presentation] Differences of gut bacterial community relateto pathology progress in Parkinson‘s disease (2017)
  • Author(s): Masaaki Hirayama, Tomomi Minato, Suzuki Anzu, Satoru Hasegawa, Yoshiro Fujisawa, Hirokazu Tsuji, Takashi Asahara, Koji Nomoto, Akira Okamoto, Tetsuya Maeda, Kinji Ohno
  • Organizer: XXIII World Congress of Neurology
  • Int'l Joint Research
• [Presentation] シンポジウム5眼球系の自律神経機能検査 (2016)
  • Author(s): 平山正昭
  • Organizer: 第69回日本自律神経学会
  • Place of Presentation: 熊本
  • Year and Date: 2016-11-09
  • Invited
• [Presentation] 腸内細菌叢がパーキンソン病の病態進展速度に与える影響 (2016)
  • Author(s): 湊 智美、鈴木 杏、長谷川 聖, 藤澤 嘉朗、辻 浩和、朝原 崇、野本 康二、岡本 陽、前田哲也、大野 欽司、平山 正昭
  • Organizer: 第10回パーキンソン病・運動疾患コングレス
  • Place of Presentation: 京都
  • Year and Date: 2016-10-09
• [Presentation] パーキンソオン病における腸内細菌叢の変動と主要禁酒の水素産生量測定 (2016)
  • Author(s): 鈴木 杏, 湊智美、長谷川 聖, 大野 欽司, 浅川 晋, 馬場 竜子, 平山 正昭
  • Organizer: 第10回パーキンソン病・運動疾患コングレス
  • Place of Presentation: 京都
  • Year and Date: 2016-10-09
• [Presentation] Perception gap for the motor and non-motor symptom between patients with Parkinson’s disease and caregiver (2016)
  • Author(s): Masaaki Hirayama, Tommi Minato, Tetsuya Made, Kenichi Kashihara
  • Organizer: 4th world parkinson congress
  • Place of Presentation: oregon
  • Year and Date: 2016-08-19
  • Int'l Joint Research
• [Presentation] Differences of gut bacterial community relate to pathology progress in Parkinsonユs disease (2016)
  • Author(s): Tomomi Minato, Satoru Hasegawa, Yoshiro Fujisawa, Hirokazu Tsuji, Takashi Asahara, Koji Nomoto, Akira Okamoto, Tetsuya Maeda, Kinji Ohno, Masaaki Hirayama
  • Organizer: 20th International congress of Parkinson's disease and movementdisordes
  • Place of Presentation: Berlin
  • Year and Date: 2016-06-18
  • Int'l Joint Research
• [Presentation] 起立性低血圧を来すパーキンソン病の自然暦の検討 (2016)
  • Author(s): 中村友彦,上田美紀,鈴木将史,平山正昭,渡邊宏久,勝野雅央
  • Organizer: 第57回日本神経学会
  • Place of Presentation: 神戸
  • Year and Date: 2016-05-18
• [Presentation] パーキンソン病における嗅覚障害と心血管系自律神経障害の継時的変化の検討 (2016)
  • Author(s): 上田美紀,中村友彦,鈴木将史,平山正昭,勝野雅央,祖父江元
  • Organizer: 第57回日本神経学会
  • Place of Presentation: 神戸
  • Year and Date: 2016-05-18
• [Presentation] パーキンソン病の睡眠障害とメラトニン分泌の関連について (2016)
  • Author(s): 鈴木将史,上田美紀,中村友彦,平山正昭,勝野雅央,祖父江元
  • Organizer: 第57回日本神経学会
  • Place of Presentation: 神戸
  • Year and Date: 2016-05-18
• [Presentation] パーキンソオン廟における腸内細菌叢の変動と主要禁酒の水素産生量測定 (2016)
  • Author(s): 鈴木杏,湊智美,長谷川聖,藤澤 嘉朗,大野欽司,浅井晋,馬場滝子、平山正昭
  • Organizer: 第57回日本神経学会
  • Place of Presentation: 神戸
  • Year and Date: 2016-05-18
• [Presentation] 腸内細菌叢がパーキンソン病の病態進展速度に与える影響 (2016)
  • Author(s): 湊智美,鈴木杏,長谷川聖,藤澤 嘉朗,辻浩和,朝原崇,野本康二,前田哲矢,大野欽司,平山正昭
  • Organizer: 第57回日本神経学会
  • Place of Presentation: 神戸
  • Year and Date: 2016-05-18
• [Presentation] 尿中8-OHdGを用いたゾニサミドによるパーキンソン病酸化的ストレスの抑制効果 (2016)
  • Author(s): 平山正昭,湊智美,前田哲矢,中村友彦,勝野雅央
  • Organizer: 第57回日本神経学会
  • Place of Presentation: 神戸
  • Year and Date: 2016-05-18
• [Presentation] Intestinal dysbiosis and lowered serum lipopolysaccharide-binding protein in Parkinson’s disease (2016)
  • Author(s): S. Hasegawa, T. Minato, T. Asahara, K. Nomoto, H. Tsuji, A. Okamoto, K. OhnoM. Hirayama,
  • Organizer: Asian and Oceanian Parkinson's disease and movement disorder congress
  • Place of Presentation: manila
  • Year and Date: 2016-03-11
  • Int'l Joint Research
• [Presentation] Intestinal dysbiosis and lowered serum lipopolysaccharide-binding protein in PD (2015)
  • Author(s): M. Hirayama, S. Hasegawa, T. Minato, T. Asahara, K. Nomoto, H. Tsuji, A. Okamoto, K. Ohno
  • Organizer: The 21th world congress on Parkinson’s disease and related disorders
  • Place of Presentation: Milano
  • Year and Date: 2015-12-05
  • Int'l Joint Research
• [Presentation] パーキンソン病早期診断マーカーとしての血液中、汗中バイオマーカーの検討 (2015)
  • Author(s): 平山正昭、角田誠、山本光利、津田孝雄、大野欽司
  • Organizer: 第９回パーキンソン病運動障害疾患コングレス
  • Place of Presentation: 東京
  • Year and Date: 2015-10-15
• [Presentation] The changes of the visual evoked magnetic field using the magnetoencephalography and its connectivity using MRI in agingand Parkinson's disease (2015)
  • Author(s): Masaaki Hirayama, Yoshiro Fujisawa, Sae Goto, Jun-ichi Uemura, Sumio Yamada, Minoru Hoshiyama
  • Organizer: the 19th International MDS Congress
  • Place of Presentation: Santiago
  • Year and Date: 2015-06-13
  • Int'l Joint Research
• [Presentation] Perception gap for the motor and non-motor symptom between patients with Parkinson’s disease and caregivers (2015)
  • Author(s): Tomomi Minato, Yoshiro Fujisawa,Satoru Hasegawa, Anzu Suzuki,Tetsuya Maeda, Kenichi Kashihara, Masaaki Hirayama
  • Organizer: The 56th 日本神経学会学術大
  • Place of Presentation: 新潟
  • Year and Date: 2015-05-20