Generator mechanism and dynamics of functional brain networks of epileptic slow activities

• Project/Area Number: 15K09351
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neurology
• Research Institution: Kyoto University
• Principal Investigator: Inouchi Morito 京都大学, 医学研究科, 客員研究員 (30532600)
• Co-Investigator(Kenkyū-buntansha): 松本 理器 京都大学, 医学研究科, 准教授 (00378754) ; 麻生 俊彦 京都大学, 医学研究科, 特定講師 (50397543) ; 國枝 武治 愛媛大学, 医学系研究科, 教授 (60609931) ; 池田 昭夫 京都大学, 医学研究科, 特定教授 (90212761)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: てんかん / 低周波活動 / 脳内ネットワーク / 機能的MRI

Outline of Final Research Achievements

Slow/infraslow activity during seizure (ictal DC) is a possible biomarker reflecting epileptogenicity, however, the generator mechanisms of ictal DC and clinical implication of interictal infraslow have not been fully understood. Also, there has been of an increasing interest in infraslow in the view point of functional networks because resting-state fMRI, analyzed by using 'slow fluctuation' of BOLD response, has been established to delineate functional networks. In the current study, we demonstrated that ictal DC was closely related to HFO during seizure, but possibly generated by different mechanisms. Such a coupling was observed also in interictal period, and we comprehensively showed the features of the coupling. By using fMRI analysis, epileptic networks could be visualized, and we demonstrated that functional connectivity could alter after epileptic surgery.

Research Products

• [Journal Article] High frequency activity overriding cortico-cortical evoked potentials reflects altered excitability in the human epileptic focus (2017)
  • Author(s): Kobayashi Katsuya、Matsumoto Riki、Matsuhashi Masao、Usami Kiyohide、Shimotake Akihiro、Kunieda Takeharu、Kikuchi Takayuki、Yoshida Kazumichi、Mikuni Nobuhiro、Miyamoto Susumu、Fukuyama Hidenao、Takahashi Ryosuke、Ikeda Akio
  • Journal Title: Clinical Neurophysiology Volume: 128 Issue: 9 Pages: 1673-1681
  • DOI: 10.1016/j.clinph.2017.06.249
  • Peer Reviewed / Open Access
• [Journal Article] Phasic REM transiently approaches wakefulness in the human cortex - a single-pulse electrical stimulation study. (2017)
  • Author(s): Usami K, Matsumoto R, Kobayashi K, Hitomi T, Matsuhashi M, Shimotake A, Kikuchi T, Yoshida K, Kunieda T, Mikuni N, Miyamoto S, Takahashi R, Ikeda A.
  • Journal Title: Sleep Volume: 40 Issue: 8 Pages: 1-7
  • DOI: 10.1093/sleep/zsx077
  • Peer Reviewed
• [Journal Article] Clinical impact of intraoperative CCEP monitoring in evaluating the dorsal language white matter pathway (2017)
  • Author(s): Yamao Y, Suzuki K, Kunieda T, Matsumoto R, Arakawa Y, Nakae T, Nishida S, Inano R, Shibata S, Shimotake A, Kikuchi, T, Sawamoto N, Mikuni N, Ikeda A, Fukuyama H, Miyamoto S
  • Journal Title: Human Brain Mapping Volume: 38 (4) Issue: 4 Pages: 1977-1991
  • DOI: 10.1002/hbm.23498
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Frontal Fibers Connecting the Superior Frontal Gyrus to Broca Area: A Corticocortical Evoked Potential Study (2017)
  • Author(s): Ookawa Satoshi、Enatsu Rei、Kanno Aya、Ochi Satoko、Akiyama Yukinori、Kobayashi Tamaki、Yamao Yukihiro、Kikuchi Takayuki、Matsumoto Riki、Kunieda Takeharu、Mikuni Nobuhiro
  • Journal Title: World Neurosurgery Volume: 107 Pages: 239-248
  • DOI: 10.1016/j.wneu.2017.07.166
  • Peer Reviewed
• [Journal Article] Magnetoencephalography with temporal spread imaging to visualize propagation of epileptic activity (2017)
  • Author(s): Shibata S, Matsuhashi M, Kunieda T, Yamao Y, Rika Inano R, Kikuchi T, Imamura H, Takaya S, Matsumoto R, Ikeda A, Takahashi R, Mima T, Fukuyama H, Mikuni N, Miyamoto S
  • Journal Title: Clin Neurophysiol Volume: 128 Issue: 5 Pages: 734-743
  • DOI: 10.1016/j.clinph.2017.01.010
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Neural pattern similarity between contra- and ipsilateral movements in high-frequency band of human electrocorticograms. (2017)
  • Author(s): Fujiwara Y, Matsumoto R, Nakae T, Usami K, Matsuhashi M, Kikuchi T, Yoshida K, Kunieda T, Miyamoto S, Mima T, Ikeda A, Osu R.
  • Journal Title: Neuroimage Volume: 15 Pages: 302-313
  • Peer Reviewed / Open Access
• [Journal Article] Single pulse electrical stimulation to probe functional and pathological connectivity in epilepsy (2017)
  • Author(s): Matsumoto R, Kunieda T, Nair D
  • Journal Title: Seizure Volume: 44 Pages: 27-36
  • DOI: 10.1016/j.seizure.2016.11.003
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Standards for data acquisition and software-based analysis of in vivo electroencephalography recordings from animals: report from the ILAE-AES joint translational task force (2017)
  • Author(s): Moyer JT, Gnatkovsky V, Ono T, Otahal J, Wagenaar J, William C. Stacey W, Noebels J, Ikeda A, Staley K, de Curtis M, Litt B, Galanopoulou AS
  • Journal Title: Epilepsia Volume: 58 Issue: S4 Pages: 53-67
  • DOI: 10.1111/epi.13909
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] How to record high frequency oscillations in epilepsy: a practical guideline (2017)
  • Author(s): Zijlmans M, Worrell G, Duempelmann M, Stieglitz T, Barborica A, Heers M, Ikeda A, Usui N, Le Van Quyen M
  • Journal Title: Epilepsia Volume: 58 Issue: 8 Pages: 1305-1315
  • DOI: 10.1111/epi.13814
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] We could predict good responders to vagus nerve stimulation: A surrogate marker by slow cortical potential shift (2017)
  • Author(s): Bayasgalan Borgil、Matsuhashi Masao、Fumuro Tomoyuki、Nohira Haruhiko、Nakano Naoki、Iida Koji、Katagiri Masaya、Shimotake Akihiro、Matsumoto Riki、Kikuchi Takayuki、Kunieda Takeharu、Kato Amami、Takahashi Ryosuke、Ikeda Akio
  • Journal Title: Clinical Neurophysiology Volume: 128 Issue: 9 Pages: 1583-1589
  • DOI: 10.1016/j.clinph.2017.05.019
  • Peer Reviewed / Open Access
• [Journal Article] Inhibition of Inwardly Rectifying Potassium (Kir) 4.1 Channels Facilitates Brain-Derived Neurotrophic Factor (BDNF) Expression in Astrocytes (2017)
  • Author(s): Kinboshi Masato、Mukai Takahiro、Nagao Yuki、Matsuba Yusuke、Tsuji Yoshimi、Tanaka Shiho、Tokudome Kentaro、Shimizu Saki、Ito Hidefumi、Ikeda Akio、Inanobe Atsushi、Kurachi Yoshihisa、Inoue Seiji、Ohno Yukihiro
  • Journal Title: Frontiers in Molecular Neuroscience Volume: 10 Pages: 408-408
  • DOI: 10.3389/fnmol.2017.00408
  • Peer Reviewed / Open Access
• [Journal Article] Lateralization of intrinsic frontoparietal network connectivity and symptoms in schizophrenia. (2017)
  • Author(s): on S, Miyata J, Mori Y, Isobe M, Urayama SI, Aso T, Fukuyama H, Murai T, Takahashi H.
  • Journal Title: Psychiatry Res. Volume: 260 Pages: 23-28
  • DOI: 10.1016/j.pscychresns.2016.12.007
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Wide band EEGの有用性 (slow) (2017)
  • Author(s): 井内盛遠、中谷光良、池田昭夫
  • Journal Title: Japanese Journal of Clinical Neurophysiology Volume: 45 Issue: 6 Pages: 520-524
  • DOI: 10.11422/jscn.45.520
  • NAID: 130006415823
  • ISSN: 1345-7101, 2188-031X
  • Peer Reviewed
• [Journal Article] Investigation of Glia Function in Intractable Epilepsy and Creation of Clinical Guideline (2017)
  • Author(s): 中谷光良、井内盛遠、大封昌子、十川純平、村井智彦、橋本聡華、稲次基希、白水洋史、金澤恭子、渡辺裕貴、臼井直敬、井上有史、前原健寿、池田昭夫
  • Journal Title: Journal of the Japan Epilepsy Society Volume: 35 Issue: 1 Pages: 3-13
  • DOI: 10.3805/jjes.35.3
  • NAID: 130005701366
  • ISSN: 0912-0890, 1347-5509
  • Peer Reviewed
• [Journal Article] CCEPのオフライン解析と解釈 (2017)
  • Author(s): 小林勝哉，松本理器，松橋眞生，中江卓郎，宇佐美清英，山尾幸広，菊池隆幸，吉田和道，國枝武治，池田昭夫
  • Journal Title: Japanese Journal of Clinical Neurophysiology Volume: 45 Issue: 2 Pages: 91-101
  • DOI: 10.11422/jscn.45.91
  • NAID: 130006351582
  • ISSN: 1345-7101, 2188-031X
  • Peer Reviewed
• [Journal Article] Neural pattern similarity between contra- and ipsilateral movements in high-frequency band of human electrocorticograms (2017)
  • Author(s): Fujiwara Y, Matsumoto R, Nakae T, Usami K, Matsuhashi M, Kikuchi T, Yoshida K, Kunieda T, Miyamoto S, Mima T, Ikeda A, Osu R
  • Journal Title: Neuroimage Volume: 15 Pages: 302-313
  • DOI: 10.1016/j.neuroimage.2016.11.058
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Phasic REM transiently approaches wakefulness in the human cortex - a single-pulse electrical stimulation study. (2017)
  • Author(s): Usami K, Matsumoto R, Kobayashi K, Hitomi T, Matsuhashi M, Shimotake A, Kikuchi T, Yoshida K, Kunieda T, Mikuni N, Miyamoto S, Takahashi R, Ikeda A
  • Journal Title: SLEEP Volume: 印刷中
  • Peer Reviewed / Open Access
• [Journal Article] Common and differential brain abnormalities in gambling disorder subtypes based on risk attitude. (2017)
  • Author(s): Takeuchi H, Tsurumi K, Murao T, Takemura A, Kawada R, Urayama SI, Aso T,Sugihara GI, Miyata J, Murai T, Takahashi H.
  • Journal Title: Addictive Behaviors Volume: 69 Pages: 48-54
  • DOI: 10.1016/j.addbeh.2017.01.025
  • Peer Reviewed / Open Access
• [Journal Article] Epileptic network of hypothalamic hamartoma: An EEG-fMRI study. (2016)
  • Author(s): Usami K, Matsumoto R, Sawamoto N, Murakami H, Inouchi M, Fumuro T, Shimotake A, Kato T, Mima T, Shirozu H, Masuda H, Fukuyama H, Takahashi R, Kameyama S, Ikeda A
  • Journal Title: Epilepsy Res Volume: 125 Pages: 1-9
  • DOI: 10.1016/j.eplepsyres.2016.05.011
  • NAID: 120006305999
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Benign adult familial myoclonus epilepsy is a progressive disorder: no longer idiopathic generalized epilepsy. (2016)
  • Author(s): Hitomi T, Kobayashi K, Sakurai T, Ueda S, Jingami N, Kanazawa K, Matsumoto R, Takahashi R, Ikeda A.
  • Journal Title: Epileptic Disord Volume: 18(1) Issue: 1 Pages: 67-72
  • DOI: 10.1684/epd.2016.0807
  • Peer Reviewed / Open Access
• [Journal Article] Elderly woman with exaggerated startle reflex and unconscious drop attack (in press) (2016)
  • Author(s): Neshige S, Kobayashi K, Shimotake A, Iemura T, Matsumoto R, Nishinaka K, Matsumoto M, Takahashi R, Ikeda A.
  • Journal Title: Neurology and Clinical Neuroscience Volume: in press Issue: 4 Pages: 156-158
  • DOI: 10.1111/ncn3.12055
  • Peer Reviewed / Open Access
• [Journal Article] Network specific change in white matter integrity in mesial temporal lobe epilepsy. (2016)
  • Author(s): Imamura, H., R. Matsumoto, S. Takaya, T. Nakagawa, A. Shimotake, T. Kikuchi, N. Sawamoto, T. Kunieda, N. Mikuni, S. Miyamoto, H. Fukuyama, R. Takahashi and A. Ikeda
  • Journal Title: Epilepsy Research Volume: 120 Pages: 65-72
  • DOI: 10.1016/j.eplepsyres.2015.12.003
  • NAID: 120005749848
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A Neural Mechanism of Preference Shifting Under Zero Price Condition. (2016)
  • Author(s): Votinov M, Aso T, Fukuyama H, Mima T.
  • Journal Title: Frontiers in Human Neuroscience Volume: 10 Pages: 177-177
  • DOI: 10.3389/fnhum.2016.00177
  • NAID: 120005947012
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Dynamic interactions of the cortical networks during thoughtsuppression. (2016)
  • Author(s): Aso T, Nishimura K, Kiyonaka T, Aoki T, Inagawa M, Matsuhashi M, Tobinaga Y,
  • Journal Title: Brain and Behavior Volume: 16;6(8) Issue: 8
  • DOI: 10.1002/brb3.503
  • Peer Reviewed / Open Access
• [Journal Article] Ambiguity aversion in schizophrenia: An fMRI study of decision-making under risk and ambiguity. (2016)
  • Author(s): Fujino J, Hirose K, Tei S, Kawada R, Tsurumi K, Matsukawa N, Miyata J,Sugihara G, Yoshihara Y, Ideno T, Aso T, Takemura K, Fukuyama H, Murai T,Takahashi H.
  • Journal Title: Schizophrenia Research Volume: 178(1-3) Issue: 1-3 Pages: 94-101
  • DOI: 10.1016/j.schres.2016.09.006
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Alpha-band desynchronization in human parietal area during reach planning (2015)
  • Author(s): Fumuro T, Matsuhashi M, Miyazaki T, Inouchi M, Hitomi T, Matsumoto R, Takahashi R, Fukuyama H, Ikeda A
  • Journal Title: Clinical Neurophysiology Volume: 126(4) Issue: 4 Pages: 756-762
  • DOI: 10.1016/j.clinph.2014.07.026
  • NAID: 120005661555
  • Peer Reviewed / Open Access
• [Journal Article] Network hyperexcitability in a patient with partial reading epilepsy: Converging evidence from magnetoencephalography, diffusion tractography, and functional magnetic resonance imaging (2015)
  • Author(s): Fumuro T, Matsumoto R, Shimotake A, Matsuhashi M, Inouchi M, Urayama S, Sawamoto N, Fukuyama H, Takahashi R, Ikeda A
  • Journal Title: Clinical Neurophysiology Volume: 126 (4) Issue: 4 Pages: 675-681
  • DOI: 10.1016/j.clinph.2014.07.033
  • NAID: 120005625620
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Possible induction of multiple seizure foci due to parietal tumour and anti-NMDAR antibody (2015)
  • Author(s): Matsumoto R, Mikuni N, Tanaka K, Usami K, Fukao K, Kunieda T, Takahashi Y, Miyamoto S, Fukuyama H, Takahashi R, Ikeda A
  • Journal Title: Epileptic Disorders Volume: 17 (1) Issue: 1 Pages: 89-94
  • DOI: 10.1684/epd.2015.0725
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Efficacy and tolerability of levetiracetam as adjunctive therapy in Japanese patients with uncontrolled partial-onset seizures. (2015)
  • Author(s): Inoue Y, Yagi K, Ikeda A, Sasagawa M, Ishida S, Suzuki A, Yoshida K
  • Journal Title: Psychiatry Clin Neurosci Volume: 印刷中 Issue: 10 Pages: 640-648
  • DOI: 10.1111/pcn.12300
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] New Approach for Exploring Cerebral Functional Connectivity: Review of Cortico-cortical Evoked Potential (2015)
  • Author(s): Kunieda T, Yamao Y, Kikuchi T, Matsumoto R
  • Journal Title: Neurologia medico-chirurgica Volume: 55 Issue: 5 Pages: 374-382
  • DOI: 10.2176/nmc.ra.2014-0388
  • NAID: 130005069876
  • ISSN: 0470-8105, 1349-8029
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Proceedings of the Seventh International Workshop on Advances in Electrocorticography. (2015)
  • Author(s): Ritaccio A, Matsumoto R, Morrell M, Kamada K, Koubeissi M, Poeppel D, Lachaux JP, Yanagisawa Y, Hirata M, Guger C, Schalk G
  • Journal Title: Epilepsy Behav Volume: 51 Pages: 312-320
  • DOI: 10.1016/j.yebeh.2015.08.002
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Sleep modulates cortical connectivity and excitability in humans: Direct evidence from neural activity induced by single-pulse electrical stimulation. (2015)
  • Author(s): Usami K, Matsumoto R, Kobayashi K, Hitomi T, Shimotake A, Kikuchi T, Matsuhashi M, Kunieda T, Mikuni N, Miyamoto S, Fukuyama H, Takahashi R, Ikeda A.
  • Journal Title: Hum Brain Mapp Volume: 36(11) Issue: 11 Pages: 4714-4729
  • DOI: 10.1002/hbm.22948
  • Peer Reviewed / Open Access
• [Journal Article] A possible variant of negative motor seizure arising from the supplementary negative motor area. (2015)
  • Author(s): Yamao Y, Matsumoto R, Kunieda K, Arakawa Y, Kikuchi T, Shibata S, Ikeda A, Fukuyama H, Miyamoto S
  • Journal Title: Clin Neurol Neurosurg Volume: 134 Pages: 126-129
  • DOI: 10.1016/j.clineuro.2015.04.024
  • NAID: 120005749924
  • Peer Reviewed / Open Access
• [Journal Article] Functional heterogeneity in the default mode network edges. (2015)
  • Author(s): Aso T, Fukuyama H
  • Journal Title: Brain Connect Volume: 5(4) Issue: 4 Pages: 203-213
  • DOI: 10.1089/brain.2014.0256
  • Peer Reviewed
• [Journal Article] Parkinson's disease patients showed delayed awareness of motor intention. (2015)
  • Author(s): Tabu H, Aso T, Matsuhashi M, Ueki Y, Takahashi R, Fukuyama H, Shibasaki H, Mima T
  • Journal Title: Neurosci Res. Volume: in press Pages: 0-0
  • DOI: 10.1016/j.neures.2015.01.012
  • Peer Reviewed
• [Journal Article] Neural correlates of mirth and laughter: A direct electrical cortical stimulation study. (2014)
  • Author(s): Yamao, Y., R. Matsumoto, T. Kunieda, S. Shibata, A. Shimotake, T. Kikuchi, T. Satow, N. Mikuni, H. Fukuyama, A. Ikeda and S. Miyamoto
  • Journal Title: Cortex Volume: - Pages: 134-40
  • DOI: 10.1016/j.cortex.2014.11.008
  • NAID: 120005749923
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] Interictal slow shifts by macroinvasive electrodes, Consensus for recording and analysis of wide-band EEG in clinical epilepsy (2017)
  • Author(s): Ikeda A
  • Organizer: Annual meeting of American Clinical Neurophysiology Society
  • Place of Presentation: Phoenix, USA
  • Year and Date: 2017-02-08
  • Int'l Joint Research / Invited
• [Presentation] 臨床てんかん病態におけるグリア機能の臨床的意義 (2017)
  • Author(s): 池田昭夫
  • Organizer: 第40回日本てんかん外科学会
  • Place of Presentation: 大阪
  • Year and Date: 2017-01-26
  • Invited
• [Presentation] How do we delineate the source of wide-band EEG data: Epileptic DC shifts and HFO? (2017)
  • Author(s): Ikeda A, Matsumoto R, Kobayashi K, Kunieda T
  • Organizer: Biomagnetic Sendai 2017
  • Int'l Joint Research / Invited
• [Presentation] Can infraslow and DC shift improve epilepsy treatment ? (2017)
  • Author(s): Ikeda A
  • Organizer: Beijing Epilepsy and Neurophysiology Summit (BENS2017)
  • Int'l Joint Research / Invited
• [Presentation] Neural basis of altered consciousness during sleep: insights from effective connectivity and induced high gamma activities (2017)
  • Author(s): Matsumoto R, Usami K, Kikuchi T, Yoshida K, Ikeda A
  • Organizer: Neural Oscillation Conference 2017
  • Int'l Joint Research / Invited
• [Presentation] Epileptic DC shift and its epileptogenic mechanism (2017)
  • Author(s): Inouchi M, Daifu M, Nakatani M, Ikeda A
  • Organizer: The 51th Congress of the Japanese Epilepsy Society annual meeting.
  • Invited
• [Presentation] てんかん発作時の wide!band EEG(発作時 DC 電位・HFO の意義 (2017)
  • Author(s): 井内盛遠
  • Organizer: The 51th Congress of the Japanese Epilepsy Society annual meeting.
  • Invited
• [Presentation] Cortico-cortical evoked potentials & soectral responses to probe connectivity and cortical excitability. (2017)
  • Author(s): Matsumoto R
  • Organizer: 51st Annual Congress of the Japan Epilepsy Societyannual meeting.
  • Invited
• [Presentation] Novel surrogate biomarkers of epileptogenicity using wideband ECoG analyses. (2017)
  • Author(s): Matsumoto R, Kobayashi K, Kikuchi T, Yoshida K, Kunieda T, Miyamoto S, Ikeda A
  • Organizer: The 76th Annual Meeting of the Japan Neurosurgery Society
  • Invited
• [Presentation] Introduction. Dual stream model of language - its function, connectivity and plasticity: insights from clinical neuroscience (2017)
  • Author(s): Matsumoto R
  • Organizer: The 40th Annual Meeting of the Japan Neuroscience Society (Neuroscience 2017)
  • Invited
• [Presentation] Glial dysfunction and intractable epilepsy-from basic to clinical studies-Glia, DC shifts/red slow, and epilepsy (難治てんかん焦点におけるグリアの役割:臨床神経生理学からのアプローチ) (2017)
  • Author(s): Ikeda A
  • Organizer: Annual congress of 60th Japanese Society for Neurochemistry
  • Invited
• [Presentation] Neuron, glia and epilepsy:is it a paradigm shift? (2017)
  • Author(s): 池田昭夫
  • Organizer: Annual congress of 51th Japanese Epilepsy Society
  • Invited
• [Presentation] 皮質脳波と高次脳機能ネットワーク (2017)
  • Author(s): 松本理器、下竹昭寛，菊池隆幸，國枝武治、池田昭夫
  • Organizer: 第47回日本臨床神経生理学会
  • Invited
• [Presentation] Spatio-temporal dynamics of interaction between slow and fast waves in humans during sleep (2017)
  • Author(s): Togawa J, Inouchi M, Matsumoto R, Matsuhashi M, Kobayashi K, Usami K, Hitomi T, Nakae T, Kikuchi T, Yoshida K, Kunieda T, Miyamoto S, Takahashi R, Ikeda A
  • Organizer: The 71st American Epilepsy Society Annual meeting 2017
  • Int'l Joint Research
• [Presentation] Co-occurrence of slow and high frequency oscillations (HFOs) in invasively recorded, interictal state in epilepsy patients: Is it a 'Red slow'? (2017)
  • Author(s): Daifu M, Inouchi M, Matsuhashi M, Kobayashi K, Shimotake A, Hitomi T, Yoshida K, Kunieda T, Matsumoto R, Takahashi R, Ikeda A
  • Organizer: The XXXⅢ World Congress of Neurology
  • Int'l Joint Research
• [Presentation] Electric cortical stimulation inhibits interictal epileptiform discharge and related high frequency activity in human epileptic focus. (2017)
  • Author(s): Nakatani M, Matsumoto R, Kobayashi K, Hitomi T, Inouchi M, Matsuhashi M, Kinoshita M, Kikuchi T, Yoshida K, Kunieda T, Takahashi R, Hattori N and Ikeda A
  • Organizer: The 71st American Epilepsy Society Annual meeting 2017
  • Int'l Joint Research
• [Presentation] Safety of single-pulse electrical stimulation for cortico-cortical evoked potentials in epileptic human cerebral cortex (2017)
  • Author(s): Kobayashi K, Matsumoto R, Usami K, Matsuhashi M, Shimotake A, Nakae T, Takeyama H, Kikuchi T, Yoshida K, Kunieda T, Takahashi R, Ikeda A
  • Organizer: The XXXⅢ World Congress of Neurology
  • Int'l Joint Research
• [Presentation] Invasive 3D source localization by wide-band electroencephalography findings (2017)
  • Author(s): Murai T, Matsuhashi M, Hitomi T, Kobayashi K, Shimotake A, Inouchi M, Kikuchi T, Yoshida K, Kunieda T, Matsumoto R, Takahashi R, Ikeda A
  • Organizer: The XXXⅢ World Congress of Neurology
  • Int'l Joint Research
• [Presentation] Inhibitory effects of electric cortical stimulation on interictal epileptiform discharges in human epileptic focus (2017)
  • Author(s): Nakatani M, Matsumoto R, Kobayashi K, Hitomi T, Inouchi M, Matsuhashi M, Kinoshita M, Kikuchi T, Yoshida K, Kunieda T, Takahashi R, Hattori N and Ikeda A
  • Organizer: The XXXⅢ World Congress of Neurology
  • Int'l Joint Research
• [Presentation] Proposal of standard recording and analysis intracranial ictal DC shifts and HFOs. (2017)
  • Author(s): Nakatani M, Inouchi M, Togawa J, Murai T, Kobayashi K, Hitomi T, Hashimoto S, Inani M, Shiroku H, Kanazawa K, Watanabe Y, Usui N, Inoue Y, Maehara T and Ikeda A
  • Organizer: The 51th Congress of the Japanese Epilepsy Society annual meeting.
• [Presentation] Inhibitory effects of electric cortical stimulation on interictal epileptiform discharges in human epileptic focus. (2017)
  • Author(s): Nakatani M, Matsumoto R, Kobayashi K, Hitomi T, Inouchi M, Matsuhashi M, Kinoshita M, Kikuchi T, Yoshida K, Kunieda T, Takahashi R, Hattori N and Ikeda A
  • Organizer: 第40回日本神経科学学術大会
• [Presentation] Increase of resting state functional connectivity after stereotactic radiofrequency thermocoagulation in the patients of hypothalamic hamartoma. (2017)
  • Author(s): Jumpei Togawa, Yosuke Ito, Toshihiko Aso, Riki Matsumoto, Morito Inouchi, Hiroshi Shirozu, Hiroshi Masuda, Ryosuke Takahashi, Masafumi Fukuda, Akio Ikeda, Shigeki Kameyama
  • Organizer: The 51th Congress of the Japanese Epilepsy Society annual meeting.
• [Presentation] Source localization of seizure focus by wide-band stereoelectroencephalography (2017)
  • Author(s): Murai T, Matsuhashi M,Hitomi T, Toho M, Kobayashi K, Shimotake A, Inouchi M, Kikuchi K, Yoshida K, Kunieda R, Matsumoto R, Kanda R, Takahashi R, Ikeda A
  • Organizer: 第51回日本てんかん学会学術集会
• [Presentation] Evidence for the engagement of cortico-cortical and cortico-subcortical networks in generation of epileptic spasms: a combined case study using CCEP and EEG-fMRI (2017)
  • Author(s): Inoue T, Kobayashi K, Matsumoto R, Inouchi M, Togo M, Togawa J, Usami K, Shimotake A, Matsuhashi M, Kikuchi T, Yoshida K, Kawawaki H, Kunieda T, Takahashi R, Ikeda A.
  • Organizer: 第51回日本てんかん学会学術集会
• [Presentation] Clinical diversity of DC shift on scalp electroencephalography (2017)
  • Author(s): Murai T, Hitomi T, Kawamura Y, Kobayashi K, Shimotake A, Matsuhashi M, Matsumoto R, Kanda R, Takahashi R, Ikeda A
  • Organizer: 第49回日本臨床神経生理学会学術大会
• [Presentation] Direct current shift on scalp electroencephalography recorded in time constant 2 sec (2017)
  • Author(s): Murai T, Hitomi T, Kawamura Y, Matsumoto R, Kanda R, Takahashi R, Ikeda A
  • Organizer: 第51回日本てんかん学会学術集会
• [Presentation] The human entorhinal cortex is connected with the broad neocortical regions through the hippocampalthalamo-cortical pathway possible as the memory network: Results from electrical tract tracing and neuropsychologicalassessment (2017)
  • Author(s): Takeyama H, Matsumoto R, Nakae T, Kobayashi K, Usami K, Shimotake A, Kikuchi T, Yoshida K, Kunieda T, Miyamoto S, Takahashi R Ikeda A
  • Organizer: 第40回日本神経科学大会
• [Presentation] Wide-band EEG analysis of epileptic seizures during pilocarpine induced status epilepticus in rat (2017)
  • Author(s): Sato K, Kinboshi M, I. Higor A, Mukai T, Matsuhashi M, Ikeda A, Ohno Y.
  • Organizer: 第51回てんかん総会学術集会
• [Presentation] Dysfunction of Kir4.1 channels facilitates BDNF production in astrocytes (2017)
  • Author(s): Kinboshi M, Mukai T, Nagao Y, Shimizu S, Ito H, Ikeda A, Ohno Y.
  • Organizer: 第 51 回日本てんかん学会学術集会
• [Presentation] 難治部分てんかん患者での単発皮質電気刺激の発作誘発率に関する安全性：皮質皮質間誘発電位計測時の検討 (2017)
  • Author(s): 小林勝哉, 松本理器, 宇佐美清英, 松橋眞生, 下竹昭寛, 中江卓郎, 武山博文, 菊池隆幸, 吉田和道, 國枝武治, 高橋良輔 and 池田昭夫
  • Organizer: 第47回日本臨床神経生理学会学術大会
• [Presentation] 発作時直流緩電位（Ictal DC shifts）の時定数10秒と2秒の記録・表示における相違：臨床的意義の検討 (2017)
  • Author(s): 梶川駿介, 小林勝哉, 中谷光良, 村井智彦, 金澤恭子, 松橋眞生, 下竹昭寛, 人見健文, 松本理器, 高橋良輔 and 池田昭夫
  • Organizer: 日本てんかん学会第51回年次集会
• [Presentation] 難治性部分てんかん患者での発作時高周波律動の時間的周波数変化と臨床相関 (2017)
  • Author(s): 藤井大樹, 小林勝哉, 下竹昭寛, 金澤恭子, 菊池隆幸, 吉田和道, 松本理器, 國枝武治, 髙橋良輔 and 池田昭夫
  • Organizer: 第47回日本臨床神経生理学会学術大会
• [Presentation] 質電気刺激による行為関連ネットワークマッピング (2017)
  • Author(s): 下竹昭寛,松本理器,小林勝哉,國枝武治,三國信啓,宮本亨,高橋良輔,池田昭夫
  • Organizer: 第47回日本臨床神経生理学会
• [Presentation] Epileptogenicity and related network: Approach from “interventional” clinical neurophysiology. Translatability between basic&clinical studies for the pathophysiology of epilepsy: Approach from Oscillology (2017)
  • Author(s): Matsumoto R, Kobayashi K, Kikuchi T, Yoshida K, Kunieda T, Ikeda A
  • Organizer: The 94th Annual meeting of the Physiological Society of Japan
  • Place of Presentation: 浜松
  • Invited
• [Presentation] 皮質電気刺激によるヒト脳内ネットワークの可視化：着想から臨床応用への道のり（指名講演1） (2017)
  • Author(s): 松本理器
  • Organizer: 平成２８年度名古屋大学脳とこころの研究センターシンポジウム
  • Place of Presentation: 名古屋
  • Invited
• [Presentation] Glia, DC shifts/red slow, and epilepsy (2016)
  • Author(s): Ikeda A
  • Organizer: 2016 Annual Meeting of Korean Neurological Association
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2016-11-04
  • Int'l Joint Research / Invited
• [Presentation] CCEPのオフライン解析と解釈（ワークショップ2 CCEPのskills workshop：clinical practice parameter（臨床実践指標）を目指して） (2016)
  • Author(s): 松本理器，小林勝哉，菊池隆幸，國枝武治，池田昭夫
  • Organizer: 第46回日本臨床神経生理学会学術大会
  • Place of Presentation: 郡山
  • Year and Date: 2016-10-27
  • Invited
• [Presentation] てんかん原性の臨床生理学的biomarker：red slowはあるか？（教育講演11） (2016)
  • Author(s): 池田昭夫
  • Organizer: 第４２回日本臨床神経生理学会
  • Place of Presentation: 郡山
  • Year and Date: 2016-10-27
  • Invited
• [Presentation] Repeated, cortical stimulation can modify the wideband cortical activity correlates of interictal epileptiform discharge (2016)
  • Author(s): Nakatani M, Matsumoto R, Kobayashi K, Hitomi T, Inouchi M, Matsuhashi M, Kinoshita M, Kunieda T, Miyamoto S, Hattori N, Takahashi R, Ikeda A
  • Organizer: 第46回日本臨床神経生理学会学術大会
  • Place of Presentation: 郡山
  • Year and Date: 2016-10-27
• [Presentation] 臨床てんかん学におけるwide-band EEGの概要と有用性 (2016)
  • Author(s): 池田昭夫
  • Organizer: 第50回日本てんかん学会学術集会
  • Place of Presentation: 静岡
  • Year and Date: 2016-10-07
  • Invited
• [Presentation] Repeated, cortical stimulation inhibits cortical epileptic excitability in human epileptic focus (2016)
  • Author(s): Nakatani M, Matsumoto R, Kobayashi K, Hitomi T, Inouchi M, Matsuhashi M, Kinoshita M, Kikuchi T, Yoshida K, Kunieda T, Takahashi R, Hattori N, Ikeda A
  • Organizer: 第50回てんかん学会学術集会
  • Place of Presentation: 静岡
  • Year and Date: 2016-10-07
• [Presentation] Invasive 3D source localization by wide-band EEG finding (2016)
  • Author(s): Murai T, Matsuhashi M, Hitomi T, Kobayashi K, Shimotake A, Inouchi M, Kikuchi T, Yoshida K, Kunieda, T, Matsumoto R, Takahashi R, Ikeda A
  • Organizer: 第50回てんかん学会学術集会
  • Place of Presentation: 静岡
  • Year and Date: 2016-10-07
• [Presentation] 発作間欠期皮質脳波における徐波と高周波律動の共起：自動検出のための解析方法についての検討 (2016)
  • Author(s): 大封昌子，井内盛遠，松橋眞生，金澤恭子，小林勝哉，下竹昭寛，人見健文，菊池隆幸，吉田和道，國枝武治，松本理器，髙橋良輔，池田昭夫
  • Organizer: 第50回日本てんかん学会学術集会
  • Place of Presentation: 静岡
  • Year and Date: 2016-10-07
• [Presentation] 意識が保持され，全身けいれん発作が群発するMRI陰性症例 (2016)
  • Author(s): 音成秀一郎，松本理器，小林勝哉，下竹昭寛，人見健文，井内盛遠，丸山博文，高橋良輔，池田昭夫
  • Organizer: 第50回日本てんかん学会学術集会
  • Place of Presentation: 静岡
  • Year and Date: 2016-10-07
• [Presentation] Repeated, cortical stimulation inhibits epileptic excitability in human epileptic focus (2016)
  • Author(s): Nakatani M, Matsumoto R, Kobayashi K, Hitomi T, Inouchi M, Matsuhashi M, Kinoshita M, Kunieda T, Miyamoto S, Hattori N, Takahashi R, Ikeda A
  • Organizer: 第57回日本神経学会学術大会
  • Place of Presentation: 神戸
  • Year and Date: 2016-05-18
• [Presentation] Enhancement of coupling between slow waves and high gamma activities during slow wave sleep in human (2016)
  • Author(s): Togawa J, Inouchi M, Matsumoto R, Matsuhashi M, Kobayashi K, Usami K, Hitomi T, Kunieda T, Miyamoto S, Takahashi R, Ikeda A
  • Organizer: 第57回日本神経学会学術大会
  • Place of Presentation: 神戸
  • Year and Date: 2016-05-18
• [Presentation] Surrogate marker of intracranially recorded ictal DC shifts and HFOs in human focal epilepsy (2016)
  • Author(s): Daifu M, Inouchi M, Kanazawa K, Matsuhashi M, Inoue T, Kobayashi K, Shimotake A, Hitomi T, Matsumoto R, Kunieda T, Miyamoto S, Takahashi R, Ikeda A
  • Organizer: 第57回日本神経学会学術大会
  • Place of Presentation: 神戸
  • Year and Date: 2016-05-18
• [Presentation] HFO synchronization and epilepsy network (2016)
  • Author(s): Ikeda A
  • Organizer: 11th Asian and Oceanian Epilepsy Congress (AOEC)
  • Place of Presentation: Hong Kong, China
  • Year and Date: 2016-05-13
  • Int'l Joint Research / Invited
• [Presentation] Exploring the mysteries of EEG: Can infraslow and DC shift improve epilepsy treatment? (2016)
  • Author(s): Ikeda A
  • Organizer: 11th Asian & Oceanian Epilepsy Congress (AOEC)
  • Place of Presentation: Hong Kong, China
  • Year and Date: 2016-05-13
  • Int'l Joint Research / Invited
• [Presentation] Advanced techniques in HFO analysis. Workshop HFOs and the Epileptogenic Zone (2016)
  • Author(s): Ikeda A
  • Organizer: 11th Asian & Oceanian Epilepsy Congress (AOEC)
  • Place of Presentation: Hong Kong, China
  • Year and Date: 2016-05-13
  • Int'l Joint Research / Invited
• [Presentation] Intracranially recorded ictal DC shifts and HFOs as surrogate markers of epileptogenicity in human focal epilepsy (2016)
  • Author(s): Daifu M, Inouchi M, Kanazawa K, Matsuhashi M, Inoue T, Kobayashi K, Shimotake A, Hitomi T, Matsumoto R, Kunieda T, Miyamoto S, Takahashi R, Ikeda A
  • Organizer: 2nd International workshop on High Frequency Oscillations in Epilepsy
  • Place of Presentation: Freiburg/Germany
  • Year and Date: 2016-03-10
  • Int'l Joint Research
• [Presentation] EEG biomarker of epilepsy (2016)
  • Author(s): Ikeda A
  • Organizer: CAOA-AOEC Joint Symposium at the 10th AESC, 10th Asian Epilepsy Surgery Congress (AESC)
  • Place of Presentation: Songdo, Korea
  • Int'l Joint Research / Invited
• [Presentation] Probing dynamics of cortico-cortical connectivity with direct cortical stimulation in physiological and pathologic states (2016)
  • Author(s): Matsumoto R
  • Organizer: Biomag 2016
  • Place of Presentation: Seoul, Korea
  • Int'l Joint Research / Invited
• [Presentation] 機能的MRI信号に含まれる種々の振動現象 (2016)
  • Author(s): 麻生俊彦
  • Organizer: 次世代脳プロジェクト2016年度冬のシンポジウム
  • Place of Presentation: 東京
• [Presentation] 血流ラグマップによる無侵襲の脳循環評価の試み (2016)
  • Author(s): 麻生俊彦
  • Organizer: 近畿神経懇話会
  • Place of Presentation: 京都
• [Presentation] Co-occurrence of slow shifts and high frequency oscillations(HFOs) in invasively recorded, interictal state: Is it called 'Red slow'? (2015)
  • Author(s): Daifu M, Inouchi M, Inoue T, Kanazawa K, Matsuhashi M, Kobayashi K, Shimotake A, Hitomi T, Matsumoto R, Kunieda T, Miyamoto S, Takahashi R, Ikeda A
  • Organizer: 第49回日本てんかん学会学術集会
  • Place of Presentation: 長崎（長崎ブリックホール・長崎新聞文化ホール）
  • Year and Date: 2015-10-30
• [Presentation] Analysis of scalp-recorded, ictal direct current shift:its sensitivity and specificity (2015)
  • Author(s): Murai T, Hitomi T, Inoue T, Kobayashi K, Shimotake A, Matsuhashi M, Inouchi M, Matsumoto R, Takahashi R, Ikeda A.
  • Organizer: 第49回日本てんかん学会学術集会
  • Place of Presentation: 長崎（長崎ブリックホール・長崎新聞文化ホール）
  • Year and Date: 2015-10-30
• [Presentation] Levetiracetam により U カーブ状の paradoxical effect を認めた 3 例 (2015)
  • Author(s): 井上岳司、酒井達也、小林勝哉、下竹昭寛、井内盛遠、松本理器、高橋良輔、池田昭夫
  • Organizer: 第49回日本てんかん学会学術集会
  • Place of Presentation: 長崎（長崎ブリックホール・長崎新聞文化ホール）
  • Year and Date: 2015-10-30
• [Presentation] Non-structural evidence of seizure focus: The role of functional imaging (2015)
  • Author(s): Ikeda A.
  • Organizer: 31st International Epilepsy Congress
  • Place of Presentation: Istanbul, Turkey
  • Year and Date: 2015-09-05
  • Int'l Joint Research / Invited
• [Presentation] Status epilepticus in the elderly in the super-aging society: clinical and EEG features and prognostic factors (2015)
  • Author(s): Yoshimura H, Matsumoto R, Ishii J, Kono T, Hoshi T, Todo K, Kawamoto M, Ariyoshi K, Ikeda A, Kohara N
  • Organizer: 31st International Epilepsy Congress
  • Place of Presentation: Istanbul, Turkey
  • Year and Date: 2015-09-05
• [Presentation] 発作間欠期の徐波と高周波数律動（HFO）の共起：難治部分てんかん患者の皮質脳波の症例検討 (2015)
  • Author(s): 井上岳司、井内盛遠、松橋眞生、松本理器、人見健文、大封昌子、小林勝哉、金澤恭子、下竹昭寛、國枝武治、高橋良輔、池田昭夫
  • Organizer: 第17回日本ヒト脳機能マッピング学会
  • Place of Presentation: 大阪（毎日新聞社 オーバルホール）
  • Year and Date: 2015-07-02
• [Presentation] ルーチン脳波による閉塞性睡眠時無呼吸スクリーニングの有用性 (2015)
  • Author(s): 井内盛遠、人見健文、松本理器、高橋良輔、陳和夫、池田昭夫
  • Organizer: 第56回日本神経学会学術総会
  • Place of Presentation: 新潟(朱鷺メッセ)
  • Year and Date: 2015-05-20
• [Book] Invasive Studies of the Human Epileptic Brain: Principles and Practice of Invasive Brain Recordings and Stimulation in Epilepsy (2018)
  • Author(s): Ikeda A
  • Publisher: Oxford University Press (London)
• [Book] Invasive Studies of the Human Epileptic Brain: Principles and Practice of Invasive Brain Recordings and Stimulation in Epilepsy (2018)
  • Author(s): Matsumoto R, Kunieda T
  • Publisher: Oxford University Press (London)
• [Book] 脳神経外科 - (4) Wide-band EEG を用いた焦点診断 - グリアとニューロン両者からのアプローチ (2018)
  • Author(s): 中谷光良、井内盛遠、前田健寿、池田昭夫
  • Publisher: 医学書院
• [Book] ガイトン生理学 - 脳の活動状態：睡眠、脳波、てんかん、精神病、認知症 (2018)
  • Author(s): 十川純平、音成秀一郎、十河正弥、池田 昭夫
  • Publisher: エルセビア・ジャパン
• [Book] 診断と治療特集 一般臨床医に必要なてんかんの基礎知識とトピックス，鈴木則宏編 (2017)
  • Author(s): 井内盛遠，松本理器
  • Publisher: 診断と治療社
• [Book] Clinical Neuroscience 37(7) - 直流脳波(DC電位） (2017)
  • Author(s): 村井智彦，井内盛遠，池田昭夫
  • Publisher: 中外医学社
• [Book] Clinical Neuroscience 35(7) - 硬膜下電極記録 (2017)
  • Author(s): 中谷光良，小林勝哉，松本理器
  • Publisher: 中外医学社
• [Book] 第1章．脳波．10．意識障害，ここが知りたい！臨床神経生理 (2016)
  • Author(s): 十川純平，松本理器
  • Total Pages: 225
  • Publisher: 中外医学社
• [Book] 第1章. 脳波．11. 脳死，ここが知りたい！臨床神経生理 (2016)
  • Author(s): 大封昌子，松本理器
  • Total Pages: 225
  • Publisher: 中外医学社
• [Book] 臨床てんかん学：1. 側頭葉てんかん. D．年齢非依存性焦点性てんかん．第11章てんかんおよびてんかん類似症候群 (2015)
  • Author(s): 井内盛遠、松本理器
  • Total Pages: 671
  • Publisher: 医学書院