| Project/Area Number |
15K09356
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Neurology
|
|---|
| Research Institution | Nara Medical University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
佐伯 圭吾 奈良県立医科大学, 医学部, 教授 (60364056)
刀根 庸浩 奈良県立医科大学, 医学部, 特任助手 (50630498)
|
|---|
| Research Collaborator |
OBAYASHI Kenji 奈良県立医科大学, 医学部, 准教授 (30596656)
|
|---|
| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Keywords | パーキンソン病 / サーカディアンリズム / 客観的睡眠 / アクチグラフィ / コントロール健常者 / 日内変動 / 睡眠覚醒リズム / 身体活動リズム / 皮膚温リズム / メラトニン分泌 |
|---|
| Outline of Final Research Achievements |
The prevalence of the sleep disturbance among patients of Parkinson disease (PD) is reported to be 40 to 60%, and it is the most common among non-motor symptoms of PD. Although a lot of studies showed lower subjective sleep quality in terms of difficulty in sleep maintenance and early awakening, evidence based on objectively measured sleep quality is limited. Recent study showed validity of sleep actigraphy among PD using optimal activity threshold to determine sleep/awake status. We conducted a cross-sectional study to compare objective sleep quality measured by actigraphy between general participants without PD, early stage PD, and late stage PD. We found significantly shorter total sleep time, lower sleep efficiency, longer wake after sleep onset, higher fragmentation index, and shorter sleep onset latency associated with progression of PD independent of potential confounders.
|
