Analysis of neuronal activity for optimization of neuromodulation therapy

• Project/Area Number: 15K09359
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neurology
• Research Institution: Juntendo University
• Principal Investigator: Shimo Yasushi 順天堂大学, 医学部, 先任准教授 (70286714)
• Co-Investigator(Kenkyū-buntansha): 梅村 淳 順天堂大学, 医学(系)研究科(研究院), 先任准教授 (00244567) ; 大山 彦光 順天堂大学, 医学部, 助手 (00407256)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2015: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
• Keywords: パーキンソン病 / 大脳基底核 / 脳深部刺激療法 / 視床下核 / local field potential / 共振現象 / 単一細胞外電位記録

Outline of Final Research Achievements

We analyze Local field potential (LFP) of the basal ganglia recorded during deep brain stimulation (DBS) therapy in Parkinson 's disease (PD) and dystonia patients. In many cases, βband oscillation was observed in the STN, and this activity was also observed in the substantia pars reticulata (SNr) and the fiber connecting the globus pallidus/ SNr to the thalamus. The βband oscillation increased with the exacerbation of parkinsonian symptom such as cogwheel rigidity and tremor. It is hypothesized that DBS reduce theβband oscillation by applying electric stimulation of the target structures to ameliorate parkinsonisms. From our results, the abnormal activity is recorded not only in the STN but also in the other basal ganglia nuclei and around the passing fiber suggesting that by including these structures as therapeutic targets, higher effects of DBS may be obtained.

Research Products

• [Journal Article] Dopamine transporter imaging predicts motor responsiveness to levodopa challenge in patients with Parkinson's disease: A pilot study of DATSCAN for subthalamic deep brain stimulation (2018)
  • Author(s): Nakajima Asuka、Shimo Yasushi、Sekimoto Satoko、Kamagata Koji、Jo Takayuki、Oyama Genko、Umemura Atsushi、Hattori Nobutaka
  • Journal Title: Journal of Neurological Sciences Volume: 385 Pages: 134-139
  • DOI: 10.1016/j.jns.2017.12.030
  • Peer Reviewed / Open Access
• [Journal Article] Association between abnormal nocturnal blood pressure profile and dementia in Parkinson's disease. (2018)
  • Author(s): Tanaka R, Shimo Y, Yamashiro K, Ogawa T, Nishioka K, Oyama G, Umemura A, Hattori N.
  • Journal Title: Parkinsonism and Related Disorders Volume: 46 Pages: 24-29
  • DOI: 10.1016/j.parkreldis.2017.10.014
  • Peer Reviewed
• [Presentation] Neuronal beta band oscillatory activity in the basal ganglia reflecting rigidity in Parkinson’s disease patients (2017)
  • Author(s): Hirokazu Iwamuro, Yasushi Shimo, Atsushi Umemura, Genko Oyama, Takayuki Jo, Satoko Sekimoto, Ryota Nakamura, Fuyuko Sasaki, Hajime Arai, Nobutaka Hatori
  • Organizer: XXIII World Congress of Neurology
  • Place of Presentation: kyoto
  • Year and Date: 2017-09-16
• [Presentation] Neuronal beta band oscillatory activity in the basal ganglia reflecting rigidity in Parkinson’s disease patients (2017)
  • Author(s): Hirokazu IWAMURO, Yasushi SHIMO, Atsushi UMEMURA, Asuka NAKAJIMA, Genko OYAMA, Takayuki JO, Satoko SEKIMOTO, Ryota NAKAMURA, Fuyuko SASAKI, Hajime ARAI, Nobutaka HATTORI
  • Organizer: 23th World Congress of Neurology
  • Int'l Joint Research
• [Presentation] The mechanisms of the STN or GPi stimulation to striatal neurons response. (2016)
  • Author(s): Asuka Nakajima, Yasushi Shimo, Takanori Uka, Nobutaka Hattori
  • Organizer: 5th Asian and Oceanian Parkinson's disease and Movement disorders congress
  • Place of Presentation: Manila
  • Year and Date: 2016-03-13
  • Int'l Joint Research
• [Presentation] Role of dopamine and gaba on primate striatal interneurons during electrical stimulation to the subthalamic nucleus and internal part of the globus pallidus (2015)
  • Author(s): Asuka Nakajima, Yasushi Shimo, Takanori Uka, Nobutaka Hattori
  • Organizer: Neuroscience 2015
  • Place of Presentation: Chicago
  • Year and Date: 2015-10-19
  • Int'l Joint Research
• [Presentation] Different effects of STN and GPi stimulation to primate striatal interneuron (2015)
  • Author(s): Asuka Nakajima, Yasushi Shimo, Takanori Uka, Nobutaka Hattori
  • Organizer: 第56回日本神経学会学術集会
  • Place of Presentation: 新潟
  • Year and Date: 2015-05-20