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Randomized double blind multi center trial of hydrogen water for Parkinson's disease

Research Project

Project/Area Number 15K09360
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Neurology
Research InstitutionJuntendo University

Principal Investigator

Yoritaka Asako  順天堂大学, 医学部, 准教授 (90245720)

Co-Investigator(Kenkyū-buntansha) 深江 治郎  福岡大学, 医学部, 准教授 (10338395)
渡辺 宏久  名古屋大学, 脳とこころの研究センター, 特任教授 (10378177)
三輪 英人  順天堂大学, 医学部, 先任准教授 (50231626)
志村 秀樹  順天堂大学, 医学部, 准教授 (50286746)
河尻 澄宏  東京女子医科大学, 医学部, 助教 (30445522)
下 泰司  順天堂大学, 医学部, 先任准教授 (70286714)
前田 哲也  岩手医科大学, 医学部, 准教授 (70359496)
大塚 千久美  岩手医科大学, 医学部, 講師 (40364343)
山田 大介  順天堂大学, 医学部, 助教 (30757539)
Research Collaborator Tomiyama Masahiko  青森県立中央病院
Abe Takashi  あべ神経内科クリニック
Hirasawa Motoyuki  東京臨海病院
Kihara Takeshi  洛和会みささぎ病院
Saiki Hidemoto  北野病院
Suzuki Tikako  Karolinska Institutet Medical University, Department of Molecularmedicine
Kzama Asuka  希望病院
Ohno Kinji  名古屋大学, 医学部, 教授
Ito Mikako  名古屋大学, 医学部, 講師
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywordsパーキンソン病 / 水素水 / 酸化的ストレス / 多施設共同無作為化二重盲検試験 / 多施設共同試験 / 無作為化2重盲検試験
Outline of Final Research Achievements

Oxidative stress is involved in Parkinson’s disease (PD) progression. Hydrogen (H2)-water reduced oxidative stress and dopaminergic neuronal cell loss in a PD model. We previously performed a randomized double-blind study where drinking H2-water for 48 weeks led to significant improvement in PD patients treated with levodopa.To confirm this result using a randomized, double-blind, placebo-controlled, multi-center trial.
One hundred and seventy-eight participants with PD (154 taking levodopa and 24 not taking levodopa) were enrolled in 14 hospitals. Participants drank 1000 ml of H2-water or placebo water per day. The changes in total Unified Parkinson’s disease rating scale (UPDRS) score from baseline to the 72nd week were used as the primary endpoint.There were no significant differences (t-test; p > 0.05) in the total UPDRS score between the H2-water and placebo groups.H2-water was safe; however, H2-water did not show a beneficial effect in PD patients.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (13 results)

All 2018 2017 2016 2015 Other

All Int'l Joint Research (3 results) Journal Article (2 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 2 results,  Open Access: 1 results) Presentation (8 results) (of which Int'l Joint Research: 3 results,  Invited: 3 results)

  • [Int'l Joint Research] カロリンスカ大学(スウェーデン)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] カロリンスカ大学(Sweden)

    • Related Report
      2016 Research-status Report
  • [Int'l Joint Research] カロリンスカ大学(Sweden)

    • Related Report
      2015 Research-status Report
  • [Journal Article] Parkinson病に対する水素水の効果 Parkinson病治療に対する新しい取り組み2017

    • Author(s)
      頼高朝子
    • Journal Title

      神経内科

      Volume: 87 Pages: 182-184

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A randomized double-blind multi-center trial of hydrogen water for Parkinson’s disease: protocol and baseline characteristics2016

    • Author(s)
      Yoritaka, A.,Abe, T.,Ohtsuka, C.,Maeda, T., Hirayama, M. et al
    • Journal Title

      BMC Neurology

      Volume: 16 Issue: 1 Pages: 66-66

    • DOI

      10.1186/s12883-016-0589-0

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] A randomized double-blind multi-center trial of hydrogen water for Parkinson’s disease2018

    • Author(s)
      Yoritaka A, Ohtsuka C, Maeda T, Hirayama M, Abe T, Watanabe H, Saiki H, Oyama G, Fukae J, Shimo Y, Hatano T, Kawajiri S, Okuma Y, Machida Y, Miwa H, Suzuki C, Kazama A, Tomiyama M, Kihara T, Hirasawa M, Shimura H, Oda E, Ito M, Ohno K, Hattori N
    • Organizer
      Advances in Alzheimer’s and Parkinson’s therapies (AAT-AD/PD)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A randomized double-blind multi-center trial of hydrogen water for Parkinson’s disease.2017

    • Author(s)
      Yoritaka A, Ohtsuka C, Maeda T, Hirayama M, Abe T, Watanabe H, Saiki H, Oyama G, Fukae J, Shimo Y, Hatano T, Kawajiri S, Okuma Y, Machida Y, Miwa H, Suzuki C, Kazama A, Tomiyama M, Kihara T, Hirasawa M, Shimura H, Oda E, Ito M, Ohno K, Hattori N
    • Organizer
      23rd World Congress of Neurology
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] パーキンソン病に対する水素水の多施設共同二重盲検無作為化試験2017

    • Author(s)
      頼高朝子、阿部隆志、大塚千久美、前田哲也、平山正昭、渡辺宏久、斎木英資、 大山彦光、深江治郎、下泰司、波田野琢、河尻澄宏、大熊泰之、町田裕、三輪英人、鈴木智香子、風間明日香、冨山誠彦、木原武士、平澤基之、志村秀樹、小田英世、服部信孝
    • Organizer
      第11回パーキンソン病・運動障害疾患コングレス
    • Related Report
      2017 Annual Research Report
  • [Presentation] パーキンソン病に対する水素水の多施設共同二重盲検無作為化試験2017

    • Author(s)
      頼高朝子、阿部隆志、大塚千久美、前田哲也、平山正昭、渡辺宏久、斎木英資、 大山彦光、深江治郎、下泰司、波田野琢、河尻澄宏、大熊泰之、町田裕、三輪英人、鈴木智香子、風間明日香、冨山誠彦、木原武士、平澤基之、志村秀樹、小田英世、伊藤美佳子、大野欽司、服部信孝
    • Organizer
      第7回分子状水素医学生物学会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 水素水のパーキンソン病に対するパイロット試験―水素水治療の可能性 水素水の可能性を考える!ー最先端研究から日常生活への取り入れ方までー2016

    • Author(s)
      頼高朝子
    • Organizer
      第16回日本抗加齢学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2016-06-10
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] A randomized double-blind multi-center trial of hydrogen water for Parkinson’s disease: protocol and baseline characteristics.2016

    • Author(s)
      頼高朝子、阿部隆志、大塚千久美、前田哲也、平山正昭、渡辺宏久、斎木英資、 大山彦光、深江治郎、等
    • Organizer
      分子状水素医学生物学会設立記念大会
    • Place of Presentation
      横浜
    • Year and Date
      2016-05-28
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] A randomized double-blind multi-center trial of hydrogen water for Parkinson’s disease: protocol and baseline characteristics2016

    • Author(s)
      Yoritaka A et al
    • Organizer
      第57回日本神経学会学術大会
    • Place of Presentation
      神戸
    • Year and Date
      2016-05-17
    • Related Report
      2016 Research-status Report
  • [Presentation] Randomized double-blind, placebo-controlled multi-center trial for determining efficacy of molecular hydrogen water for Parkinson’s disease, Baseline characteristics2015

    • Author(s)
      頼高朝子
    • Organizer
      第21回World Congress on Parkinsondisease and related disorders
    • Place of Presentation
      イタリア ミラノ
    • Year and Date
      2015-12-06
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research

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Published: 2015-04-16   Modified: 2022-10-19  

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