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Pathophysiological study of diabetes-related dementia

Research Project

Project/Area Number 15K09362
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Neurology
Research InstitutionTokyo Medical University

Principal Investigator

Hanyu Haruo  東京医科大学, 医学部, 教授 (10228520)

Co-Investigator(Kenkyū-buntansha) 石井 賢二  地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究部長 (10231135)
清水 聰一郎  東京医科大学, 医学部, 講師 (10385031)
櫻井 博文  東京医科大学, 医学部, 教授 (60235223)
松岡 正明  東京医科大学, 医学部, 主任教授 (70222297)
金高 秀和  東京医科大学, 医学部, 講師 (90385021)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords認知症 / 糖尿病 / アミロイド / タウ / アルツハイマー病 / PET / 脳脊髄液
Outline of Final Research Achievements

We studied 11C-PiB (amyloid) and 11C-PBB3 (tau) positron emission tomography (PET) in 31 subjects with diabetes-related dementia (DrD). Depending on the positivity of PiB and PBB3, we classified 21 subjects into a negative PiB and a positive PBB3 pattern (11 cases, 52%), indicating tauopathy, a positive PiB and a positive PBB3 pattern (6 cases, 29%), indicating AD pathology, or a negative PiB and a negative PBB3 pattern (4 cases, 19%). Among 11 subjects showing a negative PiB and a positive PBB3 pattern, there were 2 PBB3 deposits patterns, including the medial temporal lobe only and extensive neocortex beyond the medial temporal lobe. DrD may be associated predominantly with tau pathology, in addition to Alzheimer pathology and non-amyloid/non-tau neuronal damage due to diabetes-related metabolic abnormalities.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (30 results)

All 2018 2017 2016 2015

All Journal Article (15 results) (of which Int'l Joint Research: 7 results,  Peer Reviewed: 7 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (15 results) (of which Int'l Joint Research: 2 results,  Invited: 13 results)

  • [Journal Article] 糖尿病性認知症2018

    • Author(s)
      羽生春夫
    • Journal Title

      Dementia Japan

      Volume: 32 Pages: 48-56

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Cerebrospinal fluid analysis in individuals with diabetes-related dementia.2017

    • Author(s)
      Kanetaka H, Fukasawa R, Shimizu S, Takenoshita N, Hanyu H
    • Journal Title

      eNeurological Sci

      Volume: 8 Pages: 9-10

    • DOI

      10.1016/j.ensci.2017.06.002

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A comparison between the Mini-Mental State examination and Montreal Cognitive Assessment in assessing cognitive function in patients with diabetes-related dementia.2017

    • Author(s)
      Yamakawa H, Okita M, Fukasawa R, Hatanaka H, Namioka N, Hanyu H
    • Journal Title

      Psychogeriatrics

      Volume: 18 Issue: 1 Pages: 72-73

    • DOI

      10.1111/psyg.12277

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] 健康寿命延伸のための課題―認知症に関してー2017

    • Author(s)
      羽生春夫
    • Journal Title

      日本臨床内科医会会誌31:721-723, 2017

      Volume: 31 Pages: 721-723

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Diabetes-related dementia is associated with dynapenia, but not with sarcopenia.2017

    • Author(s)
      Hirose D, Hanyu H, Fukasawa R, Namioka N, Hatanaka H, Sato T.
    • Journal Title

      Geriatrics Gerontology International

      Volume: 17 Issue: 1 Pages: 175-177

    • DOI

      10.1111/ggi.12791

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Frailty in diabetes-related dementia.2016

    • Author(s)
      Hirose D, Hanyu H, Fukasawa R, Hatanaka H, Namioka N, Sakurai H
    • Journal Title

      Geriatrics Gerontology International

      Volume: 16 Issue: 5 Pages: 1235-1236

    • DOI

      10.1111/ggi.12566

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Peripheral oxidative stress markers in diabetes-related dementia.2016

    • Author(s)
      Hatanaka H, Hanyu H, Fukasawa R, Sato T, Shimizu S, Sakurai H.
    • Journal Title

      Geriatrics Gerontology International

      Volume: 16 Issue: 12 Pages: 1312-1318

    • DOI

      10.1111/ggi.12645

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] 糖尿病性認知症2016

    • Author(s)
      羽生春夫
    • Journal Title

      日本臨床

      Volume: 74 Pages: 495-498

    • Related Report
      2016 Research-status Report
  • [Journal Article] 糖尿病と認知症予防2016

    • Author(s)
      羽生春夫
    • Journal Title

      神経治療

      Volume: 32 Pages: 911-916

    • Related Report
      2016 Research-status Report
  • [Journal Article] 糖尿病性認知症2016

    • Author(s)
      羽生春夫
    • Journal Title

      SRL宝函

      Volume: 37 Pages: 4-10

    • Related Report
      2016 Research-status Report
  • [Journal Article] Identification of diabetes-relatde dementia:Longitudinal perfuison SPECT and amyloid PET studies.2015

    • Author(s)
      Fukasawa R, Hanyu H, Shimizu S, Kanetaka H, sakurai H, Ishi K
    • Journal Title

      Journal of the Neurological Sciences

      Volume: 349 Pages: 45-51

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Guidlines for the clinical diagnosis of diabetes mellitus-related dementia2015

    • Author(s)
      Hanyu H, hirose D, Fukasawa R, Hatanaka H, Namioka N, Sakurai H
    • Journal Title

      Journal of the American Geriatric Society

      Volume: 63 Pages: 1721-1722

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] 認知症:糖尿病性認知症の概念と臨床を含めて2015

    • Author(s)
      羽生春夫
    • Journal Title

      日本内科学会雑誌

      Volume: 104 Pages: 1901-1906

    • Related Report
      2015 Research-status Report
  • [Journal Article] 糖尿病と認知症予防2015

    • Author(s)
      羽生春夫
    • Journal Title

      神経診療学

      Volume: 32 Pages: 911-916

    • Related Report
      2015 Research-status Report
  • [Journal Article] 糖尿病患者から認知症を守る2015

    • Author(s)
      羽生春夫、深澤雷太、畑中啓邦
    • Journal Title

      糖尿病患者から認知症を守る

      Volume: 13 Pages: 664-668

    • Related Report
      2015 Research-status Report
  • [Presentation] 糖尿病合併症としての認知症とフレイル2017

    • Author(s)
      羽生春夫
    • Organizer
      第60回日本糖尿病学会年次学術集会ランチョンセミナー
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 糖尿病性認知症2017

    • Author(s)
      羽生春夫
    • Organizer
      第59回日本老年医学会学術集会 シンポジウム2糖尿病と認知症
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 老年医学からみた高齢者神経疾患の診かた2017

    • Author(s)
      羽生春夫
    • Organizer
      第35回日本神経治療学会総会 教育講演
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 認知症診療の現状と将来展望2017

    • Author(s)
      羽生春夫
    • Organizer
      第50回日本薬剤師会学術大会 特別講演
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 糖尿病合併症としての認知症とフレイル2017

    • Author(s)
      羽生春夫
    • Organizer
      第18回認知症ケア学会シンポジウム
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Amyloid and Tau PET in Diabetes-related dementia2016

    • Author(s)
      Haruo Hanyu
    • Organizer
      AAIC (Alzheimer Association International Conference) 2016
    • Place of Presentation
      Toronto(Canada)
    • Year and Date
      2016-07-24
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 糖尿病と認知症。糖尿病の観点から見た認知症の治療・予防戦略2016

    • Author(s)
      羽生春夫
    • Organizer
      第6回日本認知症予防学会学術集会
    • Place of Presentation
      仙台
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] 糖尿病性認知症のアミロイド、タウPET2016

    • Author(s)
      羽生春夫
    • Organizer
      第36回日本核医学会学術集会
    • Place of Presentation
      名古屋
    • Related Report
      2016 Research-status Report
  • [Presentation] 健康寿命延伸のための課題。認知症に関して。2016

    • Author(s)
      羽生春夫
    • Organizer
      第30回日本臨床内科医会
    • Place of Presentation
      東京
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] 血管性認知症の画像診断と糖尿病の関係2016

    • Author(s)
      羽生春夫
    • Organizer
      第35回日本認知症学会学術集会
    • Place of Presentation
      東京
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] Identification of diabetes-related dementia; neuroimaging studies2015

    • Author(s)
      Haruo Hanyu
    • Organizer
      VAS-COG 2015 TOKYO
    • Place of Presentation
      東京
    • Year and Date
      2015-09-16
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 生活習慣病からみた認知症予防2015

    • Author(s)
      羽生春夫
    • Organizer
      第57回日本老年医学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2015-06-12
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 高齢糖尿病患者の認知症の早期発見とその対策2015

    • Author(s)
      羽生春夫
    • Organizer
      第58回日本糖尿病学会学術集会
    • Place of Presentation
      下関
    • Year and Date
      2015-05-21
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 糖尿病性認知症2015

    • Author(s)
      羽生春夫
    • Organizer
      第56回日本神経学会学術集会
    • Place of Presentation
      新潟
    • Year and Date
      2015-05-20
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 糖尿病の新たな合併症:認知症2015

    • Author(s)
      羽生春夫
    • Organizer
      第112回日本内科学会学術集会
    • Place of Presentation
      京都
    • Year and Date
      2015-04-10
    • Related Report
      2015 Research-status Report
    • Invited

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Published: 2015-04-16   Modified: 2019-03-29  

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