| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
This study aimed to establish biomarkers specific to Parkinson's disease using resting state funtional MRI (rs-fMRI). Using 22 healthy elderly people, 17 cases of Parkinson's disease and 14 cases of Parkinson's syndrome (6 cases of multiple system atrophy, 6 cases of progressive supranuclear palsy, 2 cases of cortico-basal syndrome), rs-fMRI was acquired. Parkinson's disease showed a decreased functional connectivity between the default mode network and the frontal orbit network as compared with normal subjects. On the other hand, Parkinson's syndrome showed an increase in functional connectivity within the anterior cingulate network, and between the anterior cingulate network and the supplementary motor area / pre-motor area network compared to Parkinson's disease, and it was revealed that these functional connectivity changes become biomarkers.
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