Development of simplified image biomarkers for Parkinson's disease
Project/Area Number |
15K09365
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Neurology
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Research Institution | Kurume University |
Principal Investigator |
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Project Period (FY) |
2015-04-01 – 2019-03-31
|
Project Status |
Completed (Fiscal Year 2018)
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Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
Keywords | パーキンソン病 / バイオマーカー / 機能的MRI / 神経科学 / 脳・神経 / 脳神経疾患 |
Outline of Final Research Achievements |
This study aimed to establish biomarkers specific to Parkinson's disease using resting state funtional MRI (rs-fMRI). Using 22 healthy elderly people, 17 cases of Parkinson's disease and 14 cases of Parkinson's syndrome (6 cases of multiple system atrophy, 6 cases of progressive supranuclear palsy, 2 cases of cortico-basal syndrome), rs-fMRI was acquired. Parkinson's disease showed a decreased functional connectivity between the default mode network and the frontal orbit network as compared with normal subjects. On the other hand, Parkinson's syndrome showed an increase in functional connectivity within the anterior cingulate network, and between the anterior cingulate network and the supplementary motor area / pre-motor area network compared to Parkinson's disease, and it was revealed that these functional connectivity changes become biomarkers.
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Academic Significance and Societal Importance of the Research Achievements |
パーキンソン病は我が国で10万人当たり150人の有病率であり、主要な神経変性疾患である。パーキンソン病はパーキンソンニズムのうち約75%を占めるが、約25%は症候性パーキンソニズムで、血管性・薬剤性パーキンソニズムや、変性疾患(進行性核上性麻痺、多系統萎縮症、大脳皮質基底核変性症)などが含まれる。パーキンソン病は薬物療法が有効であり、予後もかなり改善されてきているが、症候性パーキンソニズムは有効な治療法はなく、特に変性疾患は予後不良であることから、臨床上両者を鑑別することは極めて重要である。この研究成果は基底核運動回路のシステム的理解、パーキンソン病の診断、重症度評価や治療薬開発補助に役立つ。
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Report
(5 results)
Research Products
(11 results)
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[Journal Article] Pathogenesis of Lethal Aspiration Pneumonia in Mecp2-null Mouse Model for Rett Syndrome.2017
Author(s)
Hiroshi Kida, Tomoyuki Takahashi, Yuki Nakamura, Takashi Kinoshita, Munetsugu Hara, Masaki Okamoto, Satoko Okayama, Keiichiro Nakamura, Ken-ichiro Kosai, Takayuki Taniwaki, Yushiro Yamashita, Toyojiro Matsuishi
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Journal Title
Scientific Reports
Volume: 7
Issue: 1
Pages: 12293-12298
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] PARK 16 polymorphism, interaction with smoking, and sporadic Parkinson’s disease in Japan2016
Author(s)
Y. Miyake, K. Tanaka, W. Fukushima, C.Kiyohara, S. Sasaki, Y.Tsuboi, T.Oeda,H.Shimada,
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Journal Title
Journal of the Neurological Science
Volume: 362
Pages: 47-52
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] A novel missense mutation of RYR1 in familial idiopathic hyper CK-emia.2015
Author(s)
K. Sano, S. Miura, T. Fujiwara, R. Fujioka, A. Yorita, K. Noda, H. Kida, K. Azuma, S. Kaieda, K. Yamamoto, T. Taniwaki, Y. Fukumaki, and H. Shibata
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Journal Title
Journal of the Neurological Sciences
Volume: 356
Issue: 1-2
Pages: 142-147
DOI
Related Report
Peer Reviewed
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