Nerve ageing and sarcopenia
| Project/Area Number |
15K09367
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | The Nukada Institute for Medical & Biological Research |
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Principal Investigator |
Nukada Hitoshi 公益財団法人額田医学生物学研究所, その他部局等, その他(移行) (60118833)
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| Co-Investigator(Kenkyū-buntansha) |
八木橋 操六 弘前大学, 医学研究科, 特任教授 (40111231)
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| Research Collaborator |
HOTTA Ryoutarou 公益財団法人額田医学生物学研究所 (50747897)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 末梢神経 / 加齢現象 / サルコペニア / Klotho マウス / 加齢 / 小径神経線維 / Klotho マウス / 神経内科 / 末梢神経障害 / 病理 |
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| Outline of Final Research Achievements |
Peripheral nerve ageing has been studied in large myelinated nerve fibers. However, ageing of small myelinated and unmyelinated nerve fibers are unknown. We have found a loss of small nerve fibres in subjects over 85 y.o. using the new techniques of skin biopsy. We have also observed severe nerve atrophy of large nerve fibres in the accerelated ageing mouse model. These results suggested that small nerve fibres are affectd by ageing as well as large nerve fibres.
As the super-aging society approaches, the understanding of ageing including the peripheral nervous system, is a societal need.
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Report
(4 results)
Research Products
(31 results)
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[Journal Article] Plasma Amino Acid Profile in Severely Frail Elderly Patients2018
Author(s)
Adachi Y, Ono N, Imaizumi A, Muramatsu T, Andou T, Shimodaira Y, Nagao K, Kageyama Y, Mori M, Noguchi Y, Hashizume N, Nukada H.
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Journal Title
International Journal of Gerontology
Volume: in press
Issue: 4
Pages: 1-4
DOI
Related Report
Peer Reviewed
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[Journal Article] Neurological Symptoms of Sarcoidosis-induced Small Fiber Neuropathy Effectively Relieved with High-dose Steroid Pulse Therapy2015
Author(s)
Saito H, Yamaguchi T, Adachi Y, Yamashita T, Wakai Y, Saito K, Shinohara Suzuki K, Yagihashi S, Terada J, Tatsumi K. Y,
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Journal Title
Intern Med
Volume: 54
Pages: 1282-1296
NAID
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Presentation] Whole-body cryotherapy in rat.2016
Author(s)
Nukada H, Hotta R, Kamimura T, Hiraga Y.
Organizer
The 43rd Annual Meeting of Japan Society for Low Temperature Medicine, “Cryomedicine 2016”
Place of Presentation
東京
Year and Date
2016-10-17
Related Report
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[Presentation] Progressive decline of compound muscle action potentials in motor nerve conduction studies in Japanese type 2 diabetic patients - four years follow-up study2015
Author(s)
Kobori M, Yagihashi S, Shiina N, ShiozawaN, Haginoya A, Ojima M, Douguchi S, Tamasawa A, Saito M, Osonoi T
Organizer
第25回欧州糖尿病学会末梢神経障害学会
Place of Presentation
Elsinore, Denmark
Year and Date
2015-09-10
Related Report
Int'l Joint Research
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[Presentation] Transplantation of Dental Pulp Stem Cells Improves Sural Nerve Morphology in Long-term Diabetic Polyneuropathy2015
Author(s)
Naruse K, Nukada H, Kobayashi Y, Nakamura N, Hata M, Ozawa S, Himeno T, Kamiya H, Nakamura J, Tanaka Y, Matsubaba T
Organizer
第75回米国糖尿病学会
Place of Presentation
Boston, USA
Year and Date
2015-06-04
Related Report
Int'l Joint Research
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