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Nerve ageing and sarcopenia

Research Project

Project/Area Number 15K09367
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Neurology
Research InstitutionThe Nukada Institute for Medical & Biological Research

Principal Investigator

Nukada Hitoshi  公益財団法人額田医学生物学研究所, その他部局等, その他(移行) (60118833)

Co-Investigator(Kenkyū-buntansha) 八木橋 操六  弘前大学, 医学研究科, 特任教授 (40111231)
Research Collaborator HOTTA Ryoutarou  公益財団法人額田医学生物学研究所 (50747897)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords末梢神経 / 加齢現象 / サルコペニア / Klotho マウス / 加齢 / 小径神経線維 / Klotho マウス / 神経内科 / 末梢神経障害 / 病理
Outline of Final Research Achievements

Peripheral nerve ageing has been studied in large myelinated nerve fibers. However, ageing of small myelinated and unmyelinated nerve fibers are unknown. We have found a loss of small nerve fibres in subjects over 85 y.o. using the new techniques of skin biopsy. We have also observed severe nerve atrophy of large nerve fibres in the accerelated ageing mouse model. These results suggested that small nerve fibres are affectd by ageing as well as large nerve fibres.
As the super-aging society approaches, the understanding of ageing including the peripheral nervous system, is a societal need.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (31 results)

All 2018 2017 2016 2015

All Journal Article (10 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 8 results,  Acknowledgement Compliant: 7 results,  Open Access: 1 results) Presentation (20 results) (of which Int'l Joint Research: 10 results,  Invited: 4 results) Book (1 results)

  • [Journal Article] Plasma Amino Acid Profile in Severely Frail Elderly Patients2018

    • Author(s)
      Adachi Y, Ono N, Imaizumi A, Muramatsu T, Andou T, Shimodaira Y, Nagao K, Kageyama Y, Mori M, Noguchi Y, Hashizume N, Nukada H.
    • Journal Title

      International Journal of Gerontology

      Volume: in press Issue: 4 Pages: 1-4

    • DOI

      10.1016/j.ijge.2018.03.003

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neuropathy in the spontaneously hypertensive rat: An electrophysiological and histological study2016

    • Author(s)
      Nukada H, Baba M, Ogasawara S, McMorran D, Yagihashi S
    • Journal Title

      Muscle Nerve

      Volume: - Issue: 4 Pages: 756-762

    • DOI

      10.1002/mus.25098

    • Related Report
      2016 Research-status Report 2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Glucotoxic Mechanisms and Related Therapeutic Approaches2016

    • Author(s)
      Yagihashi S
    • Journal Title

      Int Rev Neurobiolo

      Volume: 127 Pages: 121-149

    • DOI

      10.1016/bs.irn.2016.03.006

    • ISBN
      9780128039151
    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Dynamic pathology of islet endocrine cells in type 2 diabetes: β-Cell growth, death, regeneration and their clinical implicationas2016

    • Author(s)
      Yagihashi S, Inaba W, Mizukami H
    • Journal Title

      J Diabetes Investig

      Volume: 7 Pages: 155-165

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] The dipeptidyl peptidase IV inhibitor vildagliptin suppresses development of neuropathy in diabetic rodents: Effects on peripheral sensory nerve function, structure and molecular changes2016

    • Author(s)
      Tsuboi K, Mizukami H, Inaba W, Baba M, Yagihashi S
    • Journal Title

      Diabetologia

      Volume: 59 Issue: 4 Pages: 865-867

    • DOI

      10.1111/jnc.13439

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Neurological Symptoms of Sarcoidosis-induced Small Fiber Neuropathy Effectively Relieved with High-dose Steroid Pulse Therapy2015

    • Author(s)
      Saito H, Yamaguchi T, Adachi Y, Yamashita T, Wakai Y, Saito K, Shinohara Suzuki K, Yagihashi S, Terada J, Tatsumi K. Y,
    • Journal Title

      Intern Med

      Volume: 54 Pages: 1282-1296

    • NAID

      130005069786

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Clinical Utility of Skin Biopsy in Differentiating between Parkinson's Disease and Multiple System Atrophy2015

    • Author(s)
      Haga R, Sugimoto K, Nishijima H, Miki Y, Suzuki C, Wakabayashi K, Baba M, Yagihashi S, Tomiyama M
    • Journal Title

      Parkinsons Dis.

      Volume: 2015 Pages: 167038-167038

    • DOI

      10.1155/2015/167038

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Advances in pathology of diab europathy--a tribute to Paul Langerhans.2015

    • Author(s)
      Yagihashi S
    • Journal Title

      Pathol Int

      Volume: 65 Pages: 157-169

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] 日本人の細小血管障害の特徴,新時代の臨床糖尿病学(下巻)2015

    • Author(s)
      八木橋操六
    • Journal Title

      日本臨床(増刊号2)

      Volume: 74 Pages: 15-21

    • Related Report
      2015 Research-status Report
  • [Journal Article] 糖尿病性神経障害とは~その病理学的観点から~2015

    • Author(s)
      八木橋操六
    • Journal Title

      Diabetes Frontier

      Volume: 26 Pages: 440-447

    • Related Report
      2015 Research-status Report
  • [Presentation] Adjuvant effects of diabetes on hypertensive neuropathy in spontaneously hypertensive rats.2017

    • Author(s)
      Nukada H, Hotta R, Baba M, Ogasawara S, Yagihashi S.
    • Organizer
      NeuroDiab 2017、 the European Association for the Study of Diabetes (EASD)
    • Place of Presentation
      Coimbra, Portugal
    • Year and Date
      2017-09-09
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Adjuvant effects of diabetes on hypertensive neuropathy in spontaneously hypertensive rats.2017

    • Author(s)
      Nukada H, Hotta R, Baba M, Ogasawara S, Yagihashi S.
    • Organizer
      The 9th Scientific Meeting of the Asian Association for the Study of Diabetes
    • Place of Presentation
      名古屋
    • Year and Date
      2017-05-19
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Diabetic neuropathy2017

    • Author(s)
      Nukada H.
    • Organizer
      International Cardiometabolic Course
    • Place of Presentation
      東京
    • Year and Date
      2017-05-12
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Diabetic neuropathy2017

    • Author(s)
      Nukada H
    • Organizer
      International Cardiometabolic Course
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Adjuvant effects of diabetes on hypertensive neuropathy in spontaneously hypertensive rats.2017

    • Author(s)
      Nukada H, Hotta R, Baba M, Ogasawara S, Yagihashi S
    • Organizer
      The 9th Scientific Meeting of the Asian Association for the Study of Diabetes, Nagoya
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Adjuvant effects of diabetes on hypertensive neuropathy in spontaneously hypertensive rats.2017

    • Author(s)
      Nukada H, Hotta R, Baba M, Ogasawara S, Yagihashi S
    • Organizer
      NeuroDiab 2017, the European Association for the Study of Diabetes (EASD)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 高血圧性末梢神経障害に対する糖尿病の影響:高血圧自然発症ラット(SHR)での検討2017

    • Author(s)
      堀田亮太郎、額田 均、八木橋操六、馬場正之
    • Organizer
      平成29年度糖尿病性神経障害を考える会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Whole-body cryotherapy in rat2017

    • Author(s)
      Nukada H, Hotta R, Kamimura T, Hiraga Y
    • Organizer
      Cryomedicine 2017
    • Related Report
      2017 Annual Research Report
  • [Presentation] 高血圧性末梢神経障害に対する糖尿病の影響:高血圧自然発症ラット(SHR)での検討2017

    • Author(s)
      堀田亮太郎、額田 均、八木橋操六、馬場正之
    • Organizer
      第40回日本高血圧学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Whole-body cryotherapy in rat.2016

    • Author(s)
      Nukada H, Hotta R, Kamimura T, Hiraga Y.
    • Organizer
      The 43rd Annual Meeting of Japan Society for Low Temperature Medicine, “Cryomedicine 2016”
    • Place of Presentation
      東京
    • Year and Date
      2016-10-17
    • Related Report
      2016 Research-status Report
  • [Presentation] Hypothermic neuroprotection in reperfusion nerve injury2015

    • Author(s)
      Nukada H
    • Organizer
      第18回国際クライオサージェリー学会、第42回日本低温医学学会
    • Place of Presentation
      金沢
    • Year and Date
      2015-11-26
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 高齢者における血液中アミノ酸のバイオマーカーとしての有用性検討2015

    • Author(s)
      安達 祐介、小野 信和、村松 孝彦、下平 祥貴、影山 陽子、安東 敏彦、額田 均、橋詰 直孝
    • Organizer
      第74回日本公衆衛生学会
    • Place of Presentation
      長崎
    • Year and Date
      2015-11-04
    • Related Report
      2015 Research-status Report
  • [Presentation] 高血圧自然発症ラット(SHR)末梢神経障害に対する降圧剤の効果2015

    • Author(s)
      堀田亮太郎、額田 均、八木橋操六
    • Organizer
      第38回日本高血圧学会
    • Place of Presentation
      愛媛
    • Year and Date
      2015-10-08
    • Related Report
      2015 Research-status Report
  • [Presentation] 特発性後骨間神経麻痺における“くびれ”の病理学的検討2015

    • Author(s)
      額田 均、小松雅俊、内山茂晴、林正徳、山崎宏、 植村一貴、岩川紘子、加藤博之
    • Organizer
      第26回日本末梢神経学会
    • Place of Presentation
      松本
    • Year and Date
      2015-09-17
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 高血圧自然発症ラット(SHR)末梢神経障害に対する降圧剤の効果2015

    • Author(s)
      堀田亮太郎、額田 均、八木橋操六
    • Organizer
      第26回日本末梢神経学会
    • Place of Presentation
      松本
    • Year and Date
      2015-09-17
    • Related Report
      2015 Research-status Report
  • [Presentation] The effects of angiotensin II receptor blocker (ARB) on neuropathy in spontaneopusly hypertensive rats2015

    • Author(s)
      Hotta R, Nukada H, Yagihashi S
    • Organizer
      第25回欧州糖尿病学会末梢神経障害学会
    • Place of Presentation
      Elsinore, Denmark
    • Year and Date
      2015-09-10
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Progressive decline of compound muscle action potentials in motor nerve conduction studies in Japanese type 2 diabetic patients - four years follow-up study2015

    • Author(s)
      Kobori M, Yagihashi S, Shiina N, ShiozawaN, Haginoya A, Ojima M, Douguchi S, Tamasawa A, Saito M, Osonoi T
    • Organizer
      第25回欧州糖尿病学会末梢神経障害学会
    • Place of Presentation
      Elsinore, Denmark
    • Year and Date
      2015-09-10
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Transplantation of Dental Pulp Stem Cells Improves Sural Nerve Morphology in Long-term Diabetic Polyneuropathy2015

    • Author(s)
      Naruse K, Nukada H, Kobayashi Y, Nakamura N, Hata M, Ozawa S, Himeno T, Kamiya H, Nakamura J, Tanaka Y, Matsubaba T
    • Organizer
      第75回米国糖尿病学会
    • Place of Presentation
      Boston, USA
    • Year and Date
      2015-06-04
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 末梢神経と虚血、シンポジウム「末梢神経障害」2015

    • Author(s)
      額田 均
    • Organizer
      第58回日本手外科学会
    • Place of Presentation
      新宿
    • Year and Date
      2015-04-16
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 特発性後骨間神経麻痺における“くびれ”の病理像2015

    • Author(s)
      小松雅俊、額田 均、内山茂晴、山崎 宏、加藤博之
    • Organizer
      第58回日本手外科学会
    • Place of Presentation
      新宿
    • Year and Date
      2015-04-16
    • Related Report
      2015 Research-status Report
  • [Book] Diabetes and the nervous system, Handbook of Clinical Neurology vol. 1262015

    • Author(s)
      Nukada H
    • Publisher
      Elsevier, Edinburgh
    • Related Report
      2015 Research-status Report

URL: 

Published: 2015-04-16   Modified: 2019-04-08  

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