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Botulinum toxin injection method for oromandibular dystonia applying surgical template

Research Project

Project/Area Number 15K09370
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Neurology
Research InstitutionDepartment of Clinical Research, National Hospital Organization Kyoto Medical Center

Principal Investigator

Yoshida Kazuya  独立行政法人国立病院機構(京都医療センター臨床研究センター), 臨床研究企画運営部, 研究員 (90263087)

Project Period (FY) 2015-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywordsボツリヌス治療 / 開口ジストニア / 外側翼突筋 / サージカルテンプレート / CAD/CAM / 顎口腔ジストニア / ボツリヌス毒素 / ジストニア / 不随意運動 / 口顎ジストニア / サージカルステント / 筋電図
Outline of Final Research Achievements

The subjects were 17 patients with jaw opening dystonia which produces an involuntary opening. The scan data of the upper jaw model and CT data were superimposed on a computer, and the tip of the injection needle was designed to be the most ideal position in the lateral pterygoid muscle, and a guide for insertion was fabricated. The guide was placed in the patient's mouth, the needle was inserted into the sleeve, monitored by electromyography, subsequently 25-50 units of botulinum toxin were injected. Botulinum toxin therapy was performed 31 times without a guide and 30 times with a guide. Insertion of the needle was very easy and there were no complications. The use of guides (63.0%) increased the degree of improvement significantly (P <0.002) more than without guides (54.1%). The method is useful for accurate injection into the lateral pterygoid muscle.

Academic Significance and Societal Importance of the Research Achievements

顎口腔領域のジストニアは診断や治療が適切に行われないことが多い。診断されたとしても、外側翼突筋へのボツリヌス毒素注射は困難であり、的確に注射できなければ、効果がないばかりか出血や血腫などの副作用を伴う。本研究で開発した方法はインプラント治療の分析のためのソフトを応用し、外側翼突筋内に確実に注射針を刺入できるガイドを作製する方法である。本法を使えば、外側翼突筋への注射の経験がない医師でも、安全で確実に注射ができる。ガイドは滅菌して繰り返し使用が可能であり、臨床的な意義があると考える。

Report

(5 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (48 results)

All 2019 2018 2017 2016 2015 Other

All Journal Article (12 results) (of which Peer Reviewed: 10 results,  Open Access: 4 results,  Acknowledgement Compliant: 2 results) Presentation (21 results) (of which Int'l Joint Research: 2 results,  Invited: 4 results) Remarks (15 results)

  • [Journal Article] Oromandibular dystonia screening questionnaire for differential diagnosis.2019

    • Author(s)
      Kazuya Yoshida
    • Journal Title

      Clinical Oral Investigations

      Volume: 23 Issue: 1 Pages: 405-411

    • DOI

      10.1007/s00784-018-2449-3

    • Related Report
      2018 Annual Research Report 2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Botulinum neurotoxin therapy for lingual dystonia using an individualized injection method based on clinical features.2019

    • Author(s)
      Kazuya Yoshida
    • Journal Title

      Toxins

      Volume: 11 Issue: 1 Pages: 51-51

    • DOI

      10.3390/toxins11010051

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Sensory trick splint as a multimodal therapy for oromandibular dystonia2018

    • Author(s)
      Kazuya Yoshida
    • Journal Title

      Journal of Prosthodontic Research

      Volume: 62 Issue: 2 Pages: 239-244

    • DOI

      10.1016/j.jpor.2017.09.004

    • NAID

      130006733107

    • ISSN
      1883-1958, 1883-9207
    • Related Report
      2018 Annual Research Report 2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Multilingual website and cyberconsultations for oromandibular dystonia.2018

    • Author(s)
      Kazuya Yoshida
    • Journal Title

      Nurology International

      Volume: 10 Issue: 1 Pages: 7536-7536

    • DOI

      10.4081/ni.2018.7536

    • Related Report
      2018 Annual Research Report 2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Computer-aided design/computer-assisted manufacture-derived needle guide for injection of botulinum toxin into the lateral pterygoid muscle in patients with oromandibular dystonia.2018

    • Author(s)
      Kazuya Yoshida
    • Journal Title

      Journal of Oral & Facial Pain and Headache

      Volume: 32 Issue: 2 Pages: e13-e21

    • DOI

      10.11607/ofph.1955

    • Related Report
      2018 Annual Research Report 2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Botulinum neurotoxin injection for the treatment of recrrent temporomandibular joint dislocation with and without neurogenic muscular hypertrophy.2018

    • Author(s)
      Kazuya Yoshida
    • Journal Title

      Toxins

      Volume: 10 Issue: 5 Pages: 174-174

    • DOI

      10.3390/toxins10050174

    • Related Report
      2018 Annual Research Report 2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 私がボツリヌス治療を始めた頃.2018

    • Author(s)
      吉田和也
    • Journal Title

      日本ボツリヌス治療学会雑誌

      Volume: 4 Pages: 29-30

    • Related Report
      2018 Annual Research Report
  • [Journal Article] How do I inject botulinum toxin into the lateral and medial pterygoid muscles?2017

    • Author(s)
      Kazuya Yoshida
    • Journal Title

      Movement Disorders Clinical Practice

      Volume: 4 Issue: 2 Pages: 285-285

    • DOI

      10.1002/mdc3.12460

    • Related Report
      2017 Research-status Report 2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Clinical and phenomelogical characteristics of patients with task-specific lingual dystonia: possible association with occupation.2017

    • Author(s)
      Kazuya Yoshida
    • Journal Title

      Frontiers in Neurology

      Volume: 8 Pages: 649-649

    • DOI

      10.3389/fneur.2017.00649

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 歯ぎしりにボツリヌス治療は有効か?2017

    • Author(s)
      吉田和也
    • Journal Title

      アンチ・エイジング医学一日本抗加齢医学会雑誌

      Volume: 13 Pages: 393-398

    • Related Report
      2017 Research-status Report
  • [Journal Article] Surgical intervention for oromandibular dystonia-related limited mouth opening: Long-term follow-up.2017

    • Author(s)
      Yoshida K
    • Journal Title

      J Craniomaxillofac Surg

      Volume: 45 Issue: 1 Pages: 56-62

    • DOI

      10.1016/j.jcms.2016.10.009

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Recovery of Impaired Somatosensory Evoked Fields After Improvement of Tongue Sensory Deficits With Neurosurgical Reconstruction.2016

    • Author(s)
      Maezawa H, Tojyo I, Yoshida K, Fujita S.
    • Journal Title

      Journal of Oral and Maxillofacial Surgery

      Volume: 未定 Issue: 7 Pages: 1473-1482

    • DOI

      10.1016/j.joms.2016.01.011

    • NAID

      120005906987

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] Intramuscular injection of botulinum neurotoxin into the lateral pterygoid muscle for the treatment of recurrent temporomandibular joint dislocation with and without neurogenic muscular hyperactivity2019

    • Author(s)
      Kazuya Yoshida
    • Organizer
      The 6th Asian Academy congress for TMJ
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ボツリヌス治療の拡がり:歯科口腔疾患2019

    • Author(s)
      吉田和也
    • Organizer
      第6回日本ボツリヌス治療学会学術大会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] ボツリヌス毒素の口腔領域への臨床応用2019

    • Author(s)
      吉田和也
    • Organizer
      第47回日本歯科麻酔学会総会・学術集会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Eating habits and chewing characteristics in patients with obstructive sleep apnea syndrome2018

    • Author(s)
      Kazuya Yoshida
    • Organizer
      The 9th Congress of Asian Sleep Research Society
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Botulinum neurotoxin therapy for recurrent temporomandibular joint dislocation2018

    • Author(s)
      Kazuya Yoshida
    • Organizer
      第31回日本顎関節学会総会・学術大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 舌ジストニアに対するボツリヌス療法とMAB(Muscle afferent block)療法2018

    • Author(s)
      吉田 和也, 宮本 絵里加, 山口 隆子, 木塚 慎哉, 下郷 麻衣子, 兵 行忠
    • Organizer
      第63回 日本口腔外科学会総会・学術大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 終末期がん患者において歯科医療の関わりが奏功した広範囲ARONJの1例2018

    • Author(s)
      下郷 麻衣子, 吉田 和也, 宮本 絵里加, 木塚 慎哉, 兵 行忠
    • Organizer
      第63回 日本口腔外科学会総会・学術大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 習慣性顎関節脱臼に対するボツリヌス治療2018

    • Author(s)
      吉田 和也, 山口 隆子, 木塚 慎哉, 宮本 絵里加, 下郷 麻衣子, 兵 行忠
    • Organizer
      第72回国立病院総合医学会総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 反復性顎関節脱臼に対するボツリヌス治療2018

    • Author(s)
      吉田和也
    • Organizer
      第5回日本ボツリヌス治療学会学術大会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 舌ジストニアに対するボツリヌス療法とMAB(Muscle afferent block)療法2017

    • Author(s)
      吉田 和也
    • Organizer
      第4回日本ボツリヌス治療学会
    • Related Report
      2017 Research-status Report
  • [Presentation] Task-specific lingual dystonia is induced by occupation2017

    • Author(s)
      Yoshida K, Yamaguchi T, Miyamoto E, Shimosato M, Ono J, Hyo Y
    • Organizer
      第62回日本口腔外科学会
    • Related Report
      2017 Research-status Report
  • [Presentation] 初診時に顎関節強直症と思われた二次性閉口ジストニアによる重度開口障害の1例2017

    • Author(s)
      大野 純,吉田 和也,山口 隆子,宮本 絵里加,下郷 麻衣子,兵 行忠
    • Organizer
      第62回日本口腔外科学会
    • Related Report
      2017 Research-status Report
  • [Presentation] 顎口腔領域の不随意運動に対する歯科口腔外科的治療2017

    • Author(s)
      吉田 和也,宮本 絵里加,山口 隆子,下郷 麻衣子,大野 純,兵 行忠
    • Organizer
      第71回国立病院総合医学会
    • Related Report
      2017 Research-status Report
  • [Presentation] 下顎頭の中頭蓋内陥入を生じた関節窩骨折の1例2017

    • Author(s)
      宮本 絵里加,吉田 和也,山口 隆子,下郷 麻衣子,大野 純,兵 行忠
    • Organizer
      第62回日本口腔外科学会
    • Related Report
      2017 Research-status Report
  • [Presentation] サージカルテンプレートを応用した外側翼突筋へのボツリヌス毒素注射方法.2016

    • Author(s)
      吉田和也、大野 純、宮本絵里加、山口隆子、下郷麻衣子、兵 行忠
    • Organizer
      第61回日本口腔外科学会総会・学術大会
    • Place of Presentation
      千葉
    • Year and Date
      2016-11-25
    • Related Report
      2016 Research-status Report
  • [Presentation] 強度の開口制限をきたした閉口ジストニアに対する筋突起切離術の長期予後.2016

    • Author(s)
      吉田和也、宮本絵里加、山口隆子、下郷麻衣子、大野 純、兵 行忠
    • Organizer
      第61回日本口腔外科学会総会・学術大会
    • Place of Presentation
      千葉
    • Year and Date
      2016-11-25
    • Related Report
      2016 Research-status Report
  • [Presentation] 歯科インプラント埋入用装置を応用した外側翼突筋へのボツリヌス毒素注射法.2016

    • Author(s)
      吉田和也
    • Organizer
      第3回日本ボツリヌス治療学会学術大会
    • Place of Presentation
      東京
    • Year and Date
      2016-09-30
    • Related Report
      2016 Research-status Report
  • [Presentation] 閉口ジストニアに伴う開口制限に対する筋突起切離術の効果と予後2016

    • Author(s)
      吉田和也
    • Organizer
      第3回日本ボツリヌス治療学会学術大会
    • Place of Presentation
      東京
    • Year and Date
      2016-09-30
    • Related Report
      2016 Research-status Report
  • [Presentation] ジストニアによる顎関節脱臼とボツリヌス治療.2016

    • Author(s)
      吉田和也
    • Organizer
      第29回日本顎関節学会総会・学術大会
    • Place of Presentation
      箱根
    • Year and Date
      2016-07-17
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] Coronoidotomy for oromandibular dystonia-related limited mouth opening: long-term follow-up.2016

    • Author(s)
      Yoshida K
    • Organizer
      第29回日本顎関節学会総会・学術大会
    • Place of Presentation
      箱根
    • Year and Date
      2016-07-17
    • Related Report
      2016 Research-status Report
  • [Presentation] 顎口腔領域のジストニアの遠隔診断と医療観光2015

    • Author(s)
      吉田和也
    • Organizer
      第2回日本ボツリヌス治療学会学術大会
    • Place of Presentation
      東京コンベンションホール
    • Year and Date
      2015-10-02
    • Related Report
      2015 Research-status Report
  • [Remarks] 顎口腔領域の不随意運動

    • URL

      https://sites.google.com/site/oromadibulardystonia/

    • Related Report
      2018 Annual Research Report 2016 Research-status Report
  • [Remarks] Involuntary movements of the stomatognathic region

    • URL

      https://sites.google.com/site/oromandibulardystoniaenglish/

    • Related Report
      2018 Annual Research Report 2016 Research-status Report
  • [Remarks] Unwillkuerliche Bewegungen

    • URL

      https://sites.google.com/site/oromandibulaeredystonie/

    • Related Report
      2018 Annual Research Report
  • [Remarks] Les mouvements involontaires

    • URL

      https://sites.google.com/site/dystonieoromandibulaire/

    • Related Report
      2018 Annual Research Report 2017 Research-status Report
  • [Remarks] 下&#39052;口腔部位的不自主&#36816;&#21160;

    • URL

      https://sites.google.com/site/oromandibulardystoniachinese/

    • Related Report
      2018 Annual Research Report 2016 Research-status Report
  • [Remarks] 顎口腔領域ん不随意運動

    • URL

      https://sites.google.com/site/oromadibulardystonia/

    • Related Report
      2017 Research-status Report
  • [Remarks] Involuntary movements

    • URL

      https://sites.google.com/site/oromandibulardystoniaenglish/

    • Related Report
      2017 Research-status Report
  • [Remarks] Unwillk&#252;rliche Bewegungen

    • URL

      https://sites.google.com/site/oromandibulaeredystonie/

    • Related Report
      2017 Research-status Report
  • [Remarks] Непроизвольные движения в челюстно-ротовой области

    • URL

      https://sites.google.com/site/oromandibulardystoniarussian/

    • Related Report
      2017 Research-status Report
  • [Remarks] Oromandibul&#228;re Dystonie

    • URL

      https://sites.google.com/site/oromandibulaeredystonie/

    • Related Report
      2016 Research-status Report
  • [Remarks] Dystonie oromandibulaire

    • URL

      https://sites.google.com/site/dystonieoromandibulaire/

    • Related Report
      2016 Research-status Report 2015 Research-status Report
  • [Remarks] 口と顎のジストニア

    • URL

      https://sites.google.com/site/oromadibulardystonia/

    • Related Report
      2015 Research-status Report
  • [Remarks] Oromandibular dystonia

    • URL

      https://sites.google.com/site/oromandibulardystoniaenglish/

    • Related Report
      2015 Research-status Report
  • [Remarks] Oromandibulaere Dystonie

    • URL

      https://sites.google.com/site/oromandibulaeredystonie/

    • Related Report
      2015 Research-status Report
  • [Remarks] Оромандибулярная дистония

    • URL

      https://sites.google.com/site/oromandibulardystoniarussian/

    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2020-03-30  

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