The role of urinary NAD metabolites as new biomarkers for diabetic vascular complications
| Project/Area Number |
15K09382
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | Shiga University of Medical Science |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 糖尿病性腎症 |
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| Outline of Final Research Achievements |
In this study, we examined the role of urinary NAD metabolites as a new biomarker for diabetic vascular complications, especially nephropathy. In addition, we investigated the association between SNPs of NAD-related genes and diabetic nephropathy in Japanese patients with type 2 diabetes mellitus. As a result, urinary excretion levels of NAD+ and NMN were statistically correlated with eGFR. In addition, the allele frequencies of SNP and haplotypes in NNMT gene were significantly different between patients with diabetic nephropathy and those without it in the cross-sectional study, suggesting a relationship with nephropathy of NNMT gene.
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Report
(4 results)
Research Products
(1 results)
