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The role of urinary NAD metabolites as new biomarkers for diabetic vascular complications

Research Project

Project/Area Number 15K09382
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Metabolomics
Research InstitutionShiga University of Medical Science

Principal Investigator

Shin-ichi Araki  滋賀医科大学, 医学部, 准教授 (80378455)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords糖尿病性腎症
Outline of Final Research Achievements

In this study, we examined the role of urinary NAD metabolites as a new biomarker for diabetic vascular complications, especially nephropathy. In addition, we investigated the association between SNPs of NAD-related genes and diabetic nephropathy in Japanese patients with type 2 diabetes mellitus. As a result, urinary excretion levels of NAD+ and NMN were statistically correlated with eGFR. In addition, the allele frequencies of SNP and haplotypes in NNMT gene were significantly different between patients with diabetic nephropathy and those without it in the cross-sectional study, suggesting a relationship with nephropathy of NNMT gene.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (1 results)

All 2015

All Presentation (1 results)

  • [Presentation] NAD代謝関連酵素Nicotinamide n-methyltransferase(NNMT)は糖尿病性腎症の脂肪酸結合アルブミンによる近位尿細管障害を抑制する.2015

    • Author(s)
      田中 裕紀, 久米 真司, 中澤 純, 金崎 雅美, 荒木 久澄, 荒木 信一, 古家 大祐, 羽田 勝計, 宇津 貴, 前川 聡.
    • Organizer
      第58回日本糖尿病学会年次学術集会.
    • Place of Presentation
      山口県下関市
    • Year and Date
      2015-05-21
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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