The role of urinary NAD metabolites as new biomarkers for diabetic vascular complications

Research Project

Project/Area Number	15K09382
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Metabolomics
Research Institution	Shiga University of Medical Science
Principal Investigator	Shin-ichi Araki 滋賀医科大学, 医学部, 准教授 (80378455)
Project Period (FY)	2015-04-01 – 2018-03-31
Project Status	Completed (Fiscal Year 2017)
Budget Amount *help	¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000) Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000) Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords	糖尿病性腎症
Outline of Final Research Achievements	In this study, we examined the role of urinary NAD metabolites as a new biomarker for diabetic vascular complications, especially nephropathy. In addition, we investigated the association between SNPs of NAD-related genes and diabetic nephropathy in Japanese patients with type 2 diabetes mellitus. As a result, urinary excretion levels of NAD+ and NMN were statistically correlated with eGFR. In addition, the allele frequencies of SNP and haplotypes in NNMT gene were significantly different between patients with diabetic nephropathy and those without it in the cross-sectional study, suggesting a relationship with nephropathy of NNMT gene.