The study of development of oxytocinergic neutral circuit responding to energy status in childhood
| Project/Area Number |
15K09395
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | Fukushima Medical University |
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Principal Investigator |
Maejima Yuko 福島県立医科大学, 医学部, 准教授 (40438669)
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| Co-Investigator(Renkei-kenkyūsha) |
SHIMOMURA KENJU 福島県立医科大学, 医学部・病態制御薬理医学講座, 教授 (90636226)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 成長 / 過食 / 幼若期 / 報酬系 / GABA / 腹側被蓋野 / 摂食 / 肥満 |
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| Outline of Final Research Achievements |
The energy intake (EI) per body weight (BW) (EI/BW) in juvenile rats is known to be significantly higher than that of adult rats. The aim of this study is to clarify the mechanisms of hyperphagia in juvenile rat by comparing with that of adult rats.
This study reveled that juvenile rat may take energy up to the maximum level, regardless of the contents of meal. In other words, reward neural systems may be activated excessively in juvenile rats, compared with adult rats. In addition, we found that the low level of GABA expression in reward neural system in juvenile rats. We considered that GABA neurons in reward neural circuit contribute to hyperphagia, which is required for growth in childhood.
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Report
(4 results)
Research Products
(26 results)
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[Journal Article] Nesfatin-1 inhibits voltage gated K-channels in pancreatic beta cells.2017
Author(s)
Maejima Y, Horita S, Kobayashi D, Aoki M, O'hashi R, Imai R, Sakamoto K, Mori M, Takasu K, Ogawa K, Takenoshita S, Zhao S, Hazama A, Shimomura K
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Journal Title
Peptides
Volume: 95
Pages: 1015-1015
DOI
Related Report
Peer Reviewed
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[Journal Article] Epidemiological surveillance of Lymphocryptovirus infection in wild bonobos2016
Author(s)
Yoshida T, Takemoto H, Sakamaki T, Tokuyama N, Hart J, Hart T, Dupain J, Cobden A, Mulavwa M, Kawamoto Y, Kaneko A, Enomoto Y, Sato E, Kooriyama T, Miyabe-Nishiwaki T, Suzuki J, Saito A, Okamoto M, Tomonaga M, Matsuzawa T, Furuichi T, Akari H
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Journal Title
Frontiers in Microbiology
Volume: 7
Issue: 1
Pages: 1262-1262
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Impact of visceral fat area measured by dual impedance method on diagnostic components of metabolic diseases in a middle-aged Japanese population2016
Author(s)
Sakamaki K, Maejima Y, Tokita Y, Masamura Y, Kumamoto K, Akuzawa M, Nagano N, Nakajima K, Shimomura K, Takenoshita S, Shimomura Y
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Journal Title
Ｉｎｔｅｒｎａｌ Ｍｅｄｉｃｉｎｅ
Volume: ｉｎ ｐｒｅｓｓ
NAID
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Arcuate Na+,K+-ATPase senses systemic energy states and regulates feeding behavior through glucose-inhibited neurons.2015
Author(s)
Kurita H, Xu KY, Maejima Y, Nakata M, Dezaki K, Santoso P, Yang Y, Arai T, Gantulga D, Muroya S, Lefor AK, Kakei M, Watanabe E, Yada T.
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Journal Title
Am J Physiol Endocrinol Metab.
Volume: 309
Issue: 4
Pages: 320-333
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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